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• W4387402735 abstract "Introduction Since the beginning of the COVID-19 pandemic, a wide clinical spectrum, from asymptomatic infection to mild or severe disease and death, have been reported in COVID-19 patients. Studies have suggested several possible factors, which may affect the clinical outcome of COVID-19. A pro-inflammatory state and impaired antiviral response have been suggested as major contributing factors in severe COVID-19. Considering that mitochondria have an important role in regulating the immune responses to pathogens, pro-inflammatory signaling, and cell death, it has received much attention in SARS-CoV-2 infection. Recent studies have demonstrated that high levels of cell-free mitochondrial DNA ( cf -mtDNA) are associated with an increased risk of COVID-19 intensive care unit (ICU) admission and mortality. However, there have been few studies on cf -mtDNA in SARS-CoV-2 infection, mainly focusing on critically ill COVID-19 cases. In the present study, we investigated cf -mtDNA copy number in COVID-19 patients and compared between asymptomatic and symptomatic cases, and assessed the clinical values. We also determined the cf -nuclear DNA ( cf -nDNA) copy number and mitochondrial transcription factor A (TFAM) mRNA level in the studied groups. Materials and methods Plasma and buffy coat samples were collected from 37 COVID-19 patients and 33 controls. Briefly, after total DNA extraction, plasma cf -mtDNA, and cf -nDNA copy numbers were measured by absolute qPCR using a standard curve method. Furthermore, after total RNA extraction from buffy coat and cDNA synthesis, TFAM mRNA levels were evaluated by qPCR. Results The results showed that cf -mtDNA levels in asymptomatic COVID-19 patients were statistically significantly higher than in symptomatic cases ( p value = 0.01). However, cf -nDNA levels were higher in symptomatic patients than in asymptomatic cases ( p value = 0.00). There was no significant difference between TFAM levels in the buffy coat of these two groups ( p value &gt; 0.05). Also, cf -mtDNA levels showed good diagnostic potential in COVID-19 subgroups. Conclusion cf -mtDNA is probably important in the outcome of SARS-CoV-2 infection due to its role in inflammation and immune response. It can also be a promising candidate biomarker for the diagnosis of COVID-19 subgroups. Further investigation will help understanding the COVID-19 pathophysiology and effective diagnostic and therapeutic strategies." @default.
• W4387402735 created "2023-10-07" @default.
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• W4387402735 date "2023-10-06" @default.
• W4387402735 modified "2023-10-07" @default.
• W4387402735 title "Comparison of plasma mitochondrial DNA copy number in asymptomatic and symptomatic COVID-19 patients" @default.
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• W4387402735 doi "https://doi.org/10.3389/fmicb.2023.1256042" @default.
• W4387402735 hasPublicationYear "2023" @default.
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