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- W4387403905 abstract "Sepsis is a major life-threatening syndrome of organ dysfunction caused by a dysregulated host response due to infection. Dysregulated immunometabolism is fundamental to the onset of sepsis. Particularly, short-chain fatty acids (SCFAs) are gut microbes derived metabolites serving to drive the communication between gut microbes and the immune system, thereby exerting a profound influence on the pathophysiology of sepsis. Protein post-translational modifications (PTMs) have emerged as key players in shaping protein function, offering novel insights into the intricate connections between metabolism and phenotype regulation that characterize sepsis. Accumulating evidence from recent studies suggests that SCFAs can mediate various PTM-dependent mechanisms, modulating protein activity and influencing cellular signaling events in sepsis. This comprehensive review discusses the roles of SCFAs metabolism in sepsis associated inflammatory and immunosuppressive disorders while highlights recent advancements in SCFAs-mediated lysine acylation modifications, such as substrate supplement and enzyme regulation, which may provide new pharmacological targets for the treatment of sepsis." @default.
- W4387403905 created "2023-10-07" @default.
- W4387403905 creator A5002976916 @default.
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- W4387403905 creator A5041937683 @default.
- W4387403905 creator A5063447635 @default.
- W4387403905 creator A5066599847 @default.
- W4387403905 date "2023-10-06" @default.
- W4387403905 modified "2023-10-07" @default.
- W4387403905 title "Protein modification by short-chain fatty acid metabolites in sepsis: a comprehensive review" @default.
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