FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387405511> ?p ?o ?g. }

• W4387405511 abstract "Abstract Disclosure: S. Chimatapu: None. S. Sethuram: None. J. Samuels: None. M. Savage: None. R. Rapaport: None. Introduction: Most cases of growth hormone deficiency (GHD) in pediatric patients are idiopathic, isolated and acquired. All acquired conditions commence with a period during which the diagnosis maybe unapparent. We document here evidence for evolution of GHD in a group of adolescent males who tested sufficient on initial GH stimulation test (GST) but tested deficient upon reevaluation. The rationale for repeat GST was ongoing growth failure. Hypothesis: We hypothesize that GHD in some individuals evolves with time and can be diagnosed by repeat testing (EGHD). We also postulate that their response to GH therapy is similar to other patients with GHD. Methods: We performed an IRB-approved retrospective chart review of children who presented for short stature (height less &lt; 2SD for mean or &lt; 2SD for mid-parental height) to pediatric endocrinology at Kravis Children’s Hospital at Mount Sinai, New York and who had 2 GST. GST were performed using two different stimuli (arginine and glucagon) and highly sensitive assay serum GH measurements were processed by the same laboratory, Esoterix. No patient had obesity, chronic illnesses, or any genetic conditions affecting growth. Data were collected from electronic medical records and analyzed using SPSS v28.0 once at least half the population studied reached adult height. We defined adult height as bone age ≥ 16 years and growth velocity ≤ 2 cm/year. Results: Of 42 charts analyzed, all male, 25 had EGHD. Their average GH peak on initial GST was 15.48 ± 4.92 ng/ml, mean age 10.07 ± 2.65 years, mean height -1.68 ± 0.56 SD , IGF-1 -1.00 ± 0.88 SD. After 2.23 ± 1.22 years, at 12.04 ± 2.41years, height decreased to -1.82 ± 0.63 SD and IGF-1 was -1.08 ± 0.84 SD. At repeat GST, GH peak was 7.59 ± 2.12 ng/mL and 28% were in puberty. All patients had MRI before starting GH therapy; 40% had small anterior pituitary glands. 12 males who reached adult height had a height of -1.88 ± 0.64 SD, IGF-1 of -1.15 ± 0.81 SD, with 42% pubertal and peak GH of 7.33 ± 2.47 ng/mL at repeat GST. They had a mean height gain of 1.83 ± 0.56 SD(p&lt;0.005), with an adult height of 0.09 ± 0.70 SD after 4.64 ± 1.4years of treatment. They were 2.10 ± 4.20 cm taller than their mid-parental target heights. Discussion/Conclusions: We provide proof of concept for the diagnosis of EGHD. The diagnosis could be established by repeat GST in children with ongoing growth deceleration despite pubertal progression and a non-diagnostic initial GST. Our patients who reached adult height had a height gain consistent with that reported by KIGS for patients with growth hormone deficiency (1.7SD; Cutfield,1999) and indeed better than patients with ISS (0.7SD; Maghnie,2022). Presentation: Friday, June 16, 2023" @default.
• W4387405511 created "2023-10-07" @default.
• W4387405511 creator A5045829884 @default.
• W4387405511 creator A5063387265 @default.
• W4387405511 creator A5080785165 @default.
• W4387405511 creator A5081817728 @default.
• W4387405511 creator A5088832373 @default.
• W4387405511 date "2023-10-01" @default.
• W4387405511 modified "2023-10-07" @default.
• W4387405511 title "FRI598 Evolving Growth Hormone Deficiency: A Proof Of Concept" @default.
• W4387405511 doi "https://doi.org/10.1210/jendso/bvad114.1505" @default.
• W4387405511 hasPublicationYear "2023" @default.
• W4387405511 type Work @default.
• W4387405511 citedByCount "0" @default.
• W4387405511 crossrefType "journal-article" @default.
• W4387405511 hasAuthorship W4387405511A5045829884 @default.
• W4387405511 hasAuthorship W4387405511A5063387265 @default.
• W4387405511 hasAuthorship W4387405511A5080785165 @default.
• W4387405511 hasAuthorship W4387405511A5081817728 @default.
• W4387405511 hasAuthorship W4387405511A5088832373 @default.
• W4387405511 hasBestOaLocation W43874055111 @default.
• W4387405511 hasConcept C126322002 @default.
• W4387405511 hasConcept C134018914 @default.
• W4387405511 hasConcept C187212893 @default.
• W4387405511 hasConcept C195910791 @default.
• W4387405511 hasConcept C2776211905 @default.
• W4387405511 hasConcept C2777871287 @default.
• W4387405511 hasConcept C2778754045 @default.
• W4387405511 hasConcept C2779952775 @default.
• W4387405511 hasConcept C2908647359 @default.
• W4387405511 hasConcept C2984496839 @default.
• W4387405511 hasConcept C2991696056 @default.
• W4387405511 hasConcept C71315377 @default.
• W4387405511 hasConcept C71924100 @default.
• W4387405511 hasConcept C89551170 @default.
• W4387405511 hasConcept C99454951 @default.
• W4387405511 hasConceptScore W4387405511C126322002 @default.
• W4387405511 hasConceptScore W4387405511C134018914 @default.
• W4387405511 hasConceptScore W4387405511C187212893 @default.
• W4387405511 hasConceptScore W4387405511C195910791 @default.
• W4387405511 hasConceptScore W4387405511C2776211905 @default.
• W4387405511 hasConceptScore W4387405511C2777871287 @default.
• W4387405511 hasConceptScore W4387405511C2778754045 @default.
• W4387405511 hasConceptScore W4387405511C2779952775 @default.
• W4387405511 hasConceptScore W4387405511C2908647359 @default.
• W4387405511 hasConceptScore W4387405511C2984496839 @default.
• W4387405511 hasConceptScore W4387405511C2991696056 @default.
• W4387405511 hasConceptScore W4387405511C71315377 @default.
• W4387405511 hasConceptScore W4387405511C71924100 @default.
• W4387405511 hasConceptScore W4387405511C89551170 @default.
• W4387405511 hasConceptScore W4387405511C99454951 @default.
• W4387405511 hasIssue "Supplement_1" @default.
• W4387405511 hasLocation W43874055111 @default.
• W4387405511 hasOpenAccess W4387405511 @default.
• W4387405511 hasPrimaryLocation W43874055111 @default.
• W4387405511 hasRelatedWork W1969643105 @default.
• W4387405511 hasRelatedWork W1998681038 @default.
• W4387405511 hasRelatedWork W2094369617 @default.
• W4387405511 hasRelatedWork W2108514917 @default.
• W4387405511 hasRelatedWork W2351281197 @default.
• W4387405511 hasRelatedWork W2363270091 @default.
• W4387405511 hasRelatedWork W2989610735 @default.
• W4387405511 hasRelatedWork W4239682677 @default.
• W4387405511 hasRelatedWork W604516841 @default.
• W4387405511 hasRelatedWork W640580148 @default.
• W4387405511 hasVolume "7" @default.
• W4387405511 isParatext "false" @default.
• W4387405511 isRetracted "false" @default.
• W4387405511 workType "article" @default.