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- W4387405677 abstract "Abstract Male reproductive impairment has been linked with an increased risk of numerous non-communicable diseases. Yet, epidemiological data on renal disease among subfertile men is scarce. Therefore, by using male childlessness as a proxy for male infertility, we aimed to investigate its association with renal function. Data was sourced from a population-based cohort including 22 444 men. After exclusion of men aged < 45 years (n = 10 842), the remaining men were divided into two groups: these being childless (n = 5494) and fathers (n = 6108). Logistic regression was applied to explore the association between male childlessness and renal impairment. Childless men as compared to fathers, were more likely to have an estimated-glomerular filtration rate < 60 ml/min/1.73m 2 (OR 1.36, 95 CI 1.08–1.70; p = 0.008). After adjustment for age, marital status, smoking habits, diabetes, hypertension and other components of metabolic syndrome, childless men were also more likely to have dipstick proteinuria (OR 1.78, 95 CI 1.11–2.84; p = 0.016). With the growing panorama of disease associated with male reproductive impairment, men with fertility issues may constitute a target population with potential benefit from closer follow-up of their renal function." @default.
- W4387405677 created "2023-10-07" @default.
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- W4387405677 date "2023-10-06" @default.
- W4387405677 modified "2023-10-08" @default.
- W4387405677 title "Prevalence of impaired renal function among childless men as compared to fathers: A population-based study" @default.
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- W4387405677 doi "https://doi.org/10.21203/rs.3.rs-3395775/v1" @default.
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