Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387405972> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4387405972 abstract "Abstract Disclosure: S. Pittampalli: None. V. Pattan: None. D. Das: None. U. Munasinghe: None. Introduction: Postoperative central Diabetes insipidus is usually transient but can be persistent. Persistent central Diabetes insipidus is prone to dose fluctuations in clinically unstable patients, especially when concomitant medications influence sodium and water homeostasis. Clinical Case: A 24-year-old female with headache and confusion had sellar and suprasellar mass of 6 cm x 4 cm with moderate to severe hydrocephalus and underwent Right craniotomy with debulking of the mass and pathology showed pilocytic astrocytoma. Postoperative course was complicated by short-term memory loss, right-sided weakness, adrenal insufficiency, and visual impairment. Repeat imaging showed increased size of suprasellar mass consequently requiring a transnasal transphenoidal resection. Post-operative neurological worsening was noted along with diffuse subarachnoid/ intraventricular hemorrhage with intraparenchymal hematoma in the right frontal lobe on CTA head. Hospital course included tracheostomy with mechanical ventilation. She had panhypopituitarism including CDI. CDI was initially managed by DDAVP 10mcg intranasal nightly and free water flushes. She had central adrenal insufficiency and central hypothyroidism treated by hydrocortisone and levothyroxine respectively. Hospital stay lasted for several months with multiple adjustments to the DDAVP dosage and free water flushes due to fluctuating serum sodium levels. She was started on levetiracetam 750 mg twice daily and oxcarbazepine 300 mg twice daily for seizure like activity. After two months, the oxcarbazepine dose was increased to 450 mg twice daily and later to 600 mg twice daily for breakthrough seizures. DDAVP was then discontinued as she developed hyponatremia. The dose of oxcarbazepine was reduced to 450 mg twice daily and she was subsequently discharged to a facility off DDAVP. Discussion: Postoperative CDI managed by DDAVP was complicated with oxcarbazepine-induced hyponatremia. CDI and sodium levels were controlled with oxcarbazepine after DDAVP discontinuation. Thus, oxcarbazepine has therapeutic potential as an antidiuretic agent as it can stimulate collecting tubule V2 receptor - G protein complex independent of ADH. Presentation: Friday, June 16, 2023" @default.
- W4387405972 created "2023-10-07" @default.
- W4387405972 creator A5033619212 @default.
- W4387405972 creator A5037794996 @default.
- W4387405972 creator A5046542164 @default.
- W4387405972 creator A5068466173 @default.
- W4387405972 date "2023-10-01" @default.
- W4387405972 modified "2023-10-08" @default.
- W4387405972 title "FRI354 Therapeutic Potential Of Oxcarbazepine In Central Diabetes Insipidus" @default.
- W4387405972 doi "https://doi.org/10.1210/jendso/bvad114.1287" @default.
- W4387405972 hasPublicationYear "2023" @default.
- W4387405972 type Work @default.
- W4387405972 citedByCount "0" @default.
- W4387405972 crossrefType "journal-article" @default.
- W4387405972 hasAuthorship W4387405972A5033619212 @default.
- W4387405972 hasAuthorship W4387405972A5037794996 @default.
- W4387405972 hasAuthorship W4387405972A5046542164 @default.
- W4387405972 hasAuthorship W4387405972A5068466173 @default.
- W4387405972 hasBestOaLocation W43874059721 @default.
- W4387405972 hasConcept C118552586 @default.
- W4387405972 hasConcept C126322002 @default.
- W4387405972 hasConcept C141071460 @default.
- W4387405972 hasConcept C187212893 @default.
- W4387405972 hasConcept C2776703092 @default.
- W4387405972 hasConcept C2776958162 @default.
- W4387405972 hasConcept C2777332695 @default.
- W4387405972 hasConcept C2778129406 @default.
- W4387405972 hasConcept C2778186239 @default.
- W4387405972 hasConcept C2779253243 @default.
- W4387405972 hasConcept C2781176495 @default.
- W4387405972 hasConcept C42219234 @default.
- W4387405972 hasConcept C71924100 @default.
- W4387405972 hasConceptScore W4387405972C118552586 @default.
- W4387405972 hasConceptScore W4387405972C126322002 @default.
- W4387405972 hasConceptScore W4387405972C141071460 @default.
- W4387405972 hasConceptScore W4387405972C187212893 @default.
- W4387405972 hasConceptScore W4387405972C2776703092 @default.
- W4387405972 hasConceptScore W4387405972C2776958162 @default.
- W4387405972 hasConceptScore W4387405972C2777332695 @default.
- W4387405972 hasConceptScore W4387405972C2778129406 @default.
- W4387405972 hasConceptScore W4387405972C2778186239 @default.
- W4387405972 hasConceptScore W4387405972C2779253243 @default.
- W4387405972 hasConceptScore W4387405972C2781176495 @default.
- W4387405972 hasConceptScore W4387405972C42219234 @default.
- W4387405972 hasConceptScore W4387405972C71924100 @default.
- W4387405972 hasIssue "Supplement_1" @default.
- W4387405972 hasLocation W43874059721 @default.
- W4387405972 hasOpenAccess W4387405972 @default.
- W4387405972 hasPrimaryLocation W43874059721 @default.
- W4387405972 hasRelatedWork W2057617584 @default.
- W4387405972 hasRelatedWork W2065151935 @default.
- W4387405972 hasRelatedWork W2378145063 @default.
- W4387405972 hasRelatedWork W2378326032 @default.
- W4387405972 hasRelatedWork W2619142576 @default.
- W4387405972 hasRelatedWork W2801371457 @default.
- W4387405972 hasRelatedWork W3128083405 @default.
- W4387405972 hasRelatedWork W4213105089 @default.
- W4387405972 hasRelatedWork W4283159315 @default.
- W4387405972 hasRelatedWork W4308933328 @default.
- W4387405972 hasVolume "7" @default.
- W4387405972 isParatext "false" @default.
- W4387405972 isRetracted "false" @default.
- W4387405972 workType "article" @default.