Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387406199> ?p ?o ?g. }
- W4387406199 abstract "Background: Alzheimer’s disease (AD) is a complex disorder, and its risk is influenced by multiple genetic and environmental factors. In this study, an AD risk gene prediction framework based on spatial and temporal features of gene expression data (STGE) was proposed. Methods: We proposed an AD risk gene prediction framework based on spatial and temporal features of gene expression data. The gene expression data of providers of different tissues and ages were used as model features. Human genes were classified as AD risk or non-risk sets based on information extracted from relevant databases. Support vector machine (SVM) models were constructed to capture the expression patterns of genes believed to contribute to the risk of AD. Results: The recursive feature elimination (RFE) method was utilized for feature selection. Data for 64 tissue-age features were obtained before feature selection, and this number was reduced to 19 after RFE was performed. The SVM models were built and evaluated using 19 selected and full features. The area under curve (AUC) values for the SVM model based on 19 selected features (0.740 [0.690–0.790]) and full feature sets (0.730 [0.678–0.769]) were very similar. Fifteen genes predicted to be risk genes for AD with a probability greater than 90% were obtained. Conclusion: The newly proposed framework performed comparably to previous prediction methods based on protein-protein interaction (PPI) network properties. A list of 15 candidate genes for AD risk was also generated to provide data support for further studies on the genetic etiology of AD." @default.
- W4387406199 created "2023-10-07" @default.
- W4387406199 creator A5029654145 @default.
- W4387406199 creator A5029744067 @default.
- W4387406199 creator A5043181263 @default.
- W4387406199 creator A5049021556 @default.
- W4387406199 creator A5065036137 @default.
- W4387406199 creator A5074504591 @default.
- W4387406199 date "2023-10-06" @default.
- W4387406199 modified "2023-10-08" @default.
- W4387406199 title "Prioritization of risk genes for Alzheimer’s disease: an analysis framework using spatial and temporal gene expression data in the human brain based on support vector machine" @default.
- W4387406199 cites W1964433896 @default.
- W4387406199 cites W2080792940 @default.
- W4387406199 cites W2082524462 @default.
- W4387406199 cites W2122666578 @default.
- W4387406199 cites W2296416881 @default.
- W4387406199 cites W2512000099 @default.
- W4387406199 cites W2564588209 @default.
- W4387406199 cites W2615616680 @default.
- W4387406199 cites W2728049840 @default.
- W4387406199 cites W2754986420 @default.
- W4387406199 cites W2757409935 @default.
- W4387406199 cites W2767734009 @default.
- W4387406199 cites W2779986049 @default.
- W4387406199 cites W2790211555 @default.
- W4387406199 cites W2793416367 @default.
- W4387406199 cites W2805923143 @default.
- W4387406199 cites W2883573930 @default.
- W4387406199 cites W2889349159 @default.
- W4387406199 cites W2899480446 @default.
- W4387406199 cites W2901303766 @default.
- W4387406199 cites W2908002252 @default.
- W4387406199 cites W2908649987 @default.
- W4387406199 cites W2918491861 @default.
- W4387406199 cites W2934802914 @default.
- W4387406199 cites W2937097483 @default.
- W4387406199 cites W2947634966 @default.
- W4387406199 cites W2990620245 @default.
- W4387406199 cites W2991414673 @default.
- W4387406199 cites W3006613607 @default.
- W4387406199 cites W3112948680 @default.
- W4387406199 cites W3133859624 @default.
- W4387406199 cites W3134518262 @default.
- W4387406199 cites W3167098962 @default.
- W4387406199 cites W3177583487 @default.
- W4387406199 cites W3186792747 @default.
- W4387406199 cites W3191965259 @default.
- W4387406199 cites W3196290477 @default.
- W4387406199 cites W3207658114 @default.
- W4387406199 cites W4200147635 @default.
- W4387406199 cites W4210722399 @default.
- W4387406199 cites W4211036635 @default.
- W4387406199 cites W4220721550 @default.
- W4387406199 cites W4280490458 @default.
- W4387406199 cites W4280619985 @default.
- W4387406199 cites W4288045192 @default.
- W4387406199 cites W4320731418 @default.
- W4387406199 cites W4360613927 @default.
- W4387406199 doi "https://doi.org/10.3389/fgene.2023.1190863" @default.
- W4387406199 hasPublicationYear "2023" @default.
- W4387406199 type Work @default.
- W4387406199 citedByCount "0" @default.
- W4387406199 crossrefType "journal-article" @default.
- W4387406199 hasAuthorship W4387406199A5029654145 @default.
- W4387406199 hasAuthorship W4387406199A5029744067 @default.
- W4387406199 hasAuthorship W4387406199A5043181263 @default.
- W4387406199 hasAuthorship W4387406199A5049021556 @default.
- W4387406199 hasAuthorship W4387406199A5065036137 @default.
- W4387406199 hasAuthorship W4387406199A5074504591 @default.
- W4387406199 hasBestOaLocation W43874061991 @default.
- W4387406199 hasConcept C104317684 @default.
- W4387406199 hasConcept C119857082 @default.
- W4387406199 hasConcept C12267149 @default.
- W4387406199 hasConcept C124101348 @default.
- W4387406199 hasConcept C138885662 @default.
- W4387406199 hasConcept C148483581 @default.
- W4387406199 hasConcept C153180895 @default.
- W4387406199 hasConcept C154945302 @default.
- W4387406199 hasConcept C2776401178 @default.
- W4387406199 hasConcept C41008148 @default.
- W4387406199 hasConcept C41895202 @default.
- W4387406199 hasConcept C54355233 @default.
- W4387406199 hasConcept C70721500 @default.
- W4387406199 hasConcept C86803240 @default.
- W4387406199 hasConceptScore W4387406199C104317684 @default.
- W4387406199 hasConceptScore W4387406199C119857082 @default.
- W4387406199 hasConceptScore W4387406199C12267149 @default.
- W4387406199 hasConceptScore W4387406199C124101348 @default.
- W4387406199 hasConceptScore W4387406199C138885662 @default.
- W4387406199 hasConceptScore W4387406199C148483581 @default.
- W4387406199 hasConceptScore W4387406199C153180895 @default.
- W4387406199 hasConceptScore W4387406199C154945302 @default.
- W4387406199 hasConceptScore W4387406199C2776401178 @default.
- W4387406199 hasConceptScore W4387406199C41008148 @default.
- W4387406199 hasConceptScore W4387406199C41895202 @default.
- W4387406199 hasConceptScore W4387406199C54355233 @default.
- W4387406199 hasConceptScore W4387406199C70721500 @default.
- W4387406199 hasConceptScore W4387406199C86803240 @default.
- W4387406199 hasLocation W43874061991 @default.
- W4387406199 hasOpenAccess W4387406199 @default.