Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387406772> ?p ?o ?g. }
- W4387406772 abstract "MALAT1 long non-coding RNA has oncogenic roles but has been poorly studied in indolent B-cell neoplasms. Here, MALAT1 expression was analyzed using RNA-seq, microarrays or qRT-PCR in primary samples from clinico-biological subtypes of chronic lymphocytic leukemia (CLL, n = 266), paired Richter transformation (RT, n = 6) and follicular lymphoma (FL, n = 61). In peripheral blood (PB) CLL samples, high MALAT1 expression was associated with a significantly shorter time to treatment independently from other known prognostic factors. Coding genes expressed in association with MALAT1 in CLL were predominantly related to oncogenic pathways stimulated in the lymph node (LN) microenvironment. In RT paired samples, MALAT1 levels were lower, concordant with their acquired increased independency of external signals. Moreover, MALAT1 levels in paired PB/LN CLLs were similar, suggesting that the prognostic value of MALAT1 expression in PB is mirroring expression differences already present in LN. Similarly, high MALAT1 expression in FL predicted for a shorter progression-free survival, in association with expression pathways promoting FL pathogenesis. In summary, MALAT1 expression is related to pathophysiology and more aggressive clinical behavior of indolent B-cell neoplasms. Particularly in CLL, its levels could be a surrogate marker of the microenvironment stimulation and may contribute to refine the clinical management of these patients." @default.
- W4387406772 created "2023-10-07" @default.
- W4387406772 creator A5003221967 @default.
- W4387406772 creator A5004885234 @default.
- W4387406772 creator A5005178530 @default.
- W4387406772 creator A5008544980 @default.
- W4387406772 creator A5009720446 @default.
- W4387406772 creator A5010733763 @default.
- W4387406772 creator A5014850120 @default.
- W4387406772 creator A5019437674 @default.
- W4387406772 creator A5029161067 @default.
- W4387406772 creator A5039660745 @default.
- W4387406772 creator A5042991081 @default.
- W4387406772 creator A5052695708 @default.
- W4387406772 creator A5054614889 @default.
- W4387406772 creator A5058264336 @default.
- W4387406772 creator A5062538385 @default.
- W4387406772 creator A5070169057 @default.
- W4387406772 creator A5078999372 @default.
- W4387406772 creator A5091420701 @default.
- W4387406772 date "2023-10-06" @default.
- W4387406772 modified "2023-10-11" @default.
- W4387406772 title "MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms" @default.
- W4387406772 cites W1580176919 @default.
- W4387406772 cites W1783410048 @default.
- W4387406772 cites W1903882790 @default.
- W4387406772 cites W1965535936 @default.
- W4387406772 cites W2006413040 @default.
- W4387406772 cites W2019655196 @default.
- W4387406772 cites W2022495797 @default.
- W4387406772 cites W2029459985 @default.
- W4387406772 cites W2029742174 @default.
- W4387406772 cites W2065109737 @default.
- W4387406772 cites W2075675512 @default.
- W4387406772 cites W2082414447 @default.
- W4387406772 cites W2090739244 @default.
- W4387406772 cites W2103385435 @default.
- W4387406772 cites W2118149315 @default.
- W4387406772 cites W2119540996 @default.
- W4387406772 cites W2122450025 @default.
- W4387406772 cites W2129313223 @default.
- W4387406772 cites W2129682764 @default.
- W4387406772 cites W2143819289 @default.
- W4387406772 cites W2154889628 @default.
- W4387406772 cites W2161458853 @default.
- W4387406772 cites W2167009545 @default.
- W4387406772 cites W2168820246 @default.
- W4387406772 cites W2185820237 @default.
- W4387406772 cites W2193146434 @default.
- W4387406772 cites W2277315165 @default.
- W4387406772 cites W2403021866 @default.
- W4387406772 cites W2409205362 @default.
- W4387406772 cites W2561833005 @default.
- W4387406772 cites W2579268832 @default.
- W4387406772 cites W2589444034 @default.
- W4387406772 cites W2735687500 @default.
- W4387406772 cites W2747089052 @default.
- W4387406772 cites W2751225467 @default.
- W4387406772 cites W2791338205 @default.
- W4387406772 cites W2885057343 @default.
- W4387406772 cites W2885123310 @default.
- W4387406772 cites W2885655350 @default.
- W4387406772 cites W2890395064 @default.
- W4387406772 cites W2897570487 @default.
- W4387406772 cites W2898517758 @default.
- W4387406772 cites W2902591991 @default.
- W4387406772 cites W2903139824 @default.
- W4387406772 cites W2905297077 @default.
- W4387406772 cites W2905377006 @default.
- W4387406772 cites W2908288105 @default.
- W4387406772 cites W2920841329 @default.
- W4387406772 cites W2928523876 @default.
- W4387406772 cites W2928665623 @default.
- W4387406772 cites W2941061185 @default.
- W4387406772 cites W3004859565 @default.
- W4387406772 cites W3014025137 @default.
- W4387406772 cites W3023615359 @default.
- W4387406772 cites W3033791775 @default.
- W4387406772 cites W3089794974 @default.
- W4387406772 cites W3097796274 @default.
- W4387406772 cites W3100688200 @default.
- W4387406772 cites W3128598379 @default.
- W4387406772 cites W3164176768 @default.
- W4387406772 cites W3164888346 @default.
- W4387406772 cites W3213848811 @default.
- W4387406772 cites W4244151789 @default.
- W4387406772 cites W4292488390 @default.
- W4387406772 cites W4313477643 @default.
- W4387406772 cites W4313830893 @default.
- W4387406772 cites W4376999543 @default.
- W4387406772 cites W630675343 @default.
- W4387406772 cites W957112403 @default.
- W4387406772 doi "https://doi.org/10.1038/s41598-023-44174-8" @default.
- W4387406772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37803049" @default.
- W4387406772 hasPublicationYear "2023" @default.
- W4387406772 type Work @default.
- W4387406772 citedByCount "0" @default.
- W4387406772 crossrefType "journal-article" @default.
- W4387406772 hasAuthorship W4387406772A5003221967 @default.
- W4387406772 hasAuthorship W4387406772A5004885234 @default.