Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387407870> ?p ?o ?g. }
- W4387407870 abstract "Mounting evidence highlights the crucial role of aging in the pathogenesis of Alzheimer's disease (AD). We have previously explored human apoE-targeted replacement mice across different ages and identified distinct molecular pathways driven by aging. However, the specific contribution of different brain cell types to the gene modules underlying these pathways remained elusive. To bridge this knowledge gap, we employed a computational deconvolution approach to examine cell-type-specific gene expression profiles in major brain cell types, including astrocytes (AS), microglia (MG), oligodendroglia (OG), neurons (NEU), and vascular cells (VC). Our findings revealed that immune module genes were predominantly expressed in MG, OG, and VC. The lipid metabolism module genes were primarily expressed in AS, MG, and OG. The mitochondria module genes showed prominent expression in VC, and the synapse module genes were primarily expressed in NEU and VC. Furthermore, we identified intra- and inter-cell-type interactions among these module genes and validated their aging-associated expression changes using published single cell studies. Our study dissected bulk brain transcriptomics data at the cellular level, providing a closer examination of the cell-type contributions to the molecular pathways driven by aging." @default.
- W4387407870 created "2023-10-07" @default.
- W4387407870 creator A5020353300 @default.
- W4387407870 creator A5022178171 @default.
- W4387407870 creator A5040897632 @default.
- W4387407870 creator A5062732888 @default.
- W4387407870 creator A5065172118 @default.
- W4387407870 creator A5073656125 @default.
- W4387407870 creator A5074141991 @default.
- W4387407870 creator A5084505603 @default.
- W4387407870 creator A5085073400 @default.
- W4387407870 creator A5087318569 @default.
- W4387407870 date "2023-10-06" @default.
- W4387407870 modified "2023-10-11" @default.
- W4387407870 title "Deconvolution reveals cell-type-specific transcriptomic changes in the aging mouse brain" @default.
- W4387407870 cites W1966327575 @default.
- W4387407870 cites W1994300200 @default.
- W4387407870 cites W2013517836 @default.
- W4387407870 cites W2019249853 @default.
- W4387407870 cites W2053632281 @default.
- W4387407870 cites W2071493890 @default.
- W4387407870 cites W2085667648 @default.
- W4387407870 cites W2094204544 @default.
- W4387407870 cites W2103813752 @default.
- W4387407870 cites W2126525177 @default.
- W4387407870 cites W2128211963 @default.
- W4387407870 cites W2147985567 @default.
- W4387407870 cites W2149076862 @default.
- W4387407870 cites W2159566868 @default.
- W4387407870 cites W2159675211 @default.
- W4387407870 cites W2169101662 @default.
- W4387407870 cites W2190545194 @default.
- W4387407870 cites W2405825843 @default.
- W4387407870 cites W2406250479 @default.
- W4387407870 cites W2552241218 @default.
- W4387407870 cites W2746479894 @default.
- W4387407870 cites W2806989085 @default.
- W4387407870 cites W2886347923 @default.
- W4387407870 cites W2898901335 @default.
- W4387407870 cites W2928665623 @default.
- W4387407870 cites W2933804670 @default.
- W4387407870 cites W2933846292 @default.
- W4387407870 cites W2942610007 @default.
- W4387407870 cites W2946373463 @default.
- W4387407870 cites W2952001873 @default.
- W4387407870 cites W2970272608 @default.
- W4387407870 cites W2975507539 @default.
- W4387407870 cites W3005155384 @default.
- W4387407870 cites W3006871825 @default.
- W4387407870 cites W3011658331 @default.
- W4387407870 cites W3019556496 @default.
- W4387407870 cites W3034508641 @default.
- W4387407870 cites W3084281165 @default.
- W4387407870 cites W3128194933 @default.
- W4387407870 cites W3164692211 @default.
- W4387407870 cites W3194004635 @default.
- W4387407870 cites W3199972090 @default.
- W4387407870 cites W3204727461 @default.
- W4387407870 cites W4211154726 @default.
- W4387407870 cites W4294329053 @default.
- W4387407870 cites W4295903538 @default.
- W4387407870 cites W4313312704 @default.
- W4387407870 cites W4313432435 @default.
- W4387407870 cites W4323037201 @default.
- W4387407870 cites W4323545951 @default.
- W4387407870 doi "https://doi.org/10.1038/s41598-023-44183-7" @default.
- W4387407870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37803069" @default.
- W4387407870 hasPublicationYear "2023" @default.
- W4387407870 type Work @default.
- W4387407870 citedByCount "0" @default.
- W4387407870 crossrefType "journal-article" @default.
- W4387407870 hasAuthorship W4387407870A5020353300 @default.
- W4387407870 hasAuthorship W4387407870A5022178171 @default.
- W4387407870 hasAuthorship W4387407870A5040897632 @default.
- W4387407870 hasAuthorship W4387407870A5062732888 @default.
- W4387407870 hasAuthorship W4387407870A5065172118 @default.
- W4387407870 hasAuthorship W4387407870A5073656125 @default.
- W4387407870 hasAuthorship W4387407870A5074141991 @default.
- W4387407870 hasAuthorship W4387407870A5084505603 @default.
- W4387407870 hasAuthorship W4387407870A5085073400 @default.
- W4387407870 hasAuthorship W4387407870A5087318569 @default.
- W4387407870 hasBestOaLocation W43874078701 @default.
- W4387407870 hasConcept C104317684 @default.
- W4387407870 hasConcept C145059251 @default.
- W4387407870 hasConcept C1491633281 @default.
- W4387407870 hasConcept C150194340 @default.
- W4387407870 hasConcept C162317418 @default.
- W4387407870 hasConcept C169760540 @default.
- W4387407870 hasConcept C169900460 @default.
- W4387407870 hasConcept C189014844 @default.
- W4387407870 hasConcept C203014093 @default.
- W4387407870 hasConcept C2776914184 @default.
- W4387407870 hasConcept C2779695026 @default.
- W4387407870 hasConcept C2779830541 @default.
- W4387407870 hasConcept C54355233 @default.
- W4387407870 hasConcept C70721500 @default.
- W4387407870 hasConcept C86803240 @default.
- W4387407870 hasConcept C95444343 @default.
- W4387407870 hasConceptScore W4387407870C104317684 @default.
- W4387407870 hasConceptScore W4387407870C145059251 @default.