Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387408075> ?p ?o ?g. }
- W4387408075 endingPage "2412" @default.
- W4387408075 startingPage "2412" @default.
- W4387408075 abstract "Axonal degeneration resulting from optic nerve damage can lead to the progressive death of retinal ganglion cells (RGCs), culminating in irreversible vision loss. We contrasted two methods for inducing optic nerve damage: optic nerve compression (ONCo) and optic nerve crush (ONCr). These were assessed for their respective merits in simulating traumatic optic neuropathies and neurodegeneration. We also administered neural progenitor cells (NPCs) into the subtenon space to validate their potential in mitigating optic nerve damage. Our findings indicate that both ONCo and ONCr successfully induced optic nerve damage, as shown by increases in ischemia and expression of genes linked to neuronal regeneration. Post NPC injection, recovery in the expression of neuronal regeneration-related genes was more pronounced in the ONCo model than in the ONCr model, while inflammation-related gene expression saw a better recovery in ONCr. In addition, the proteomic analysis of R28 cells in hypoxic conditions identified Vps35 and Syntaxin12 genes. Vps35 preserved the mitochondrial function in ONCo, while Syntaxin12 appeared to restrain inflammation via the Wnt/β-catenin signaling pathway in ONCr. NPCs managed to restore damaged RGCs by elevating neuroprotection factors and controlling inflammation through mitochondrial homeostasis and Wnt/β-catenin signaling in hypoxia-injured R28 cells and in both animal models. Our results suggest that ischemic injury and crush injury cause optic nerve damage via different mechanisms, which can be effectively simulated using ONCo and ONCr, respectively. Moreover, cell-based therapies such as NPCs may offer promising avenues for treating various optic neuropathies, including ischemic and crush injuries." @default.
- W4387408075 created "2023-10-07" @default.
- W4387408075 creator A5016994312 @default.
- W4387408075 creator A5059078273 @default.
- W4387408075 creator A5067153846 @default.
- W4387408075 creator A5068737921 @default.
- W4387408075 creator A5072888597 @default.
- W4387408075 creator A5080030701 @default.
- W4387408075 creator A5080823003 @default.
- W4387408075 creator A5087019672 @default.
- W4387408075 date "2023-10-06" @default.
- W4387408075 modified "2023-10-16" @default.
- W4387408075 title "Unveiling Neuroprotection and Regeneration Mechanisms in Optic Nerve Injury: Insight from Neural Progenitor Cell Therapy with Focus on Vps35 and Syntaxin12" @default.
- W4387408075 cites W1864669235 @default.
- W4387408075 cites W1985106059 @default.
- W4387408075 cites W2016482156 @default.
- W4387408075 cites W2037199116 @default.
- W4387408075 cites W2040942688 @default.
- W4387408075 cites W2042282721 @default.
- W4387408075 cites W2046172278 @default.
- W4387408075 cites W2069368135 @default.
- W4387408075 cites W2093433016 @default.
- W4387408075 cites W2095577265 @default.
- W4387408075 cites W2114680086 @default.
- W4387408075 cites W2133954552 @default.
- W4387408075 cites W2141420900 @default.
- W4387408075 cites W2159809160 @default.
- W4387408075 cites W2298425058 @default.
- W4387408075 cites W2473972827 @default.
- W4387408075 cites W2528491208 @default.
- W4387408075 cites W2556290582 @default.
- W4387408075 cites W2597734448 @default.
- W4387408075 cites W2735882751 @default.
- W4387408075 cites W2798204203 @default.
- W4387408075 cites W2884217857 @default.
- W4387408075 cites W2907283267 @default.
- W4387408075 cites W2912078659 @default.
- W4387408075 cites W2960681055 @default.
- W4387408075 cites W2990922207 @default.
- W4387408075 cites W2994895262 @default.
- W4387408075 cites W2996262470 @default.
- W4387408075 cites W3033441680 @default.
- W4387408075 cites W3092119968 @default.
- W4387408075 cites W3109112463 @default.
- W4387408075 cites W3124805470 @default.
- W4387408075 cites W3134588537 @default.
- W4387408075 cites W3157847381 @default.
- W4387408075 cites W3165294998 @default.
- W4387408075 cites W3172952474 @default.
- W4387408075 cites W3212805494 @default.
- W4387408075 cites W3216420207 @default.
- W4387408075 cites W4200218540 @default.
- W4387408075 cites W4200511666 @default.
- W4387408075 cites W4205788778 @default.
- W4387408075 cites W4206075628 @default.
- W4387408075 cites W4214947446 @default.
- W4387408075 cites W4220831425 @default.
- W4387408075 cites W4292004419 @default.
- W4387408075 cites W4309839523 @default.
- W4387408075 cites W4360862191 @default.
- W4387408075 doi "https://doi.org/10.3390/cells12192412" @default.
- W4387408075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37830626" @default.
- W4387408075 hasPublicationYear "2023" @default.
- W4387408075 type Work @default.
- W4387408075 citedByCount "0" @default.
- W4387408075 crossrefType "journal-article" @default.
- W4387408075 hasAuthorship W4387408075A5016994312 @default.
- W4387408075 hasAuthorship W4387408075A5059078273 @default.
- W4387408075 hasAuthorship W4387408075A5067153846 @default.
- W4387408075 hasAuthorship W4387408075A5068737921 @default.
- W4387408075 hasAuthorship W4387408075A5072888597 @default.
- W4387408075 hasAuthorship W4387408075A5080030701 @default.
- W4387408075 hasAuthorship W4387408075A5080823003 @default.
- W4387408075 hasAuthorship W4387408075A5087019672 @default.
- W4387408075 hasBestOaLocation W43874080751 @default.
- W4387408075 hasConcept C136834591 @default.
- W4387408075 hasConcept C137620995 @default.
- W4387408075 hasConcept C169760540 @default.
- W4387408075 hasConcept C171056886 @default.
- W4387408075 hasConcept C25498285 @default.
- W4387408075 hasConcept C2780837183 @default.
- W4387408075 hasConcept C28328180 @default.
- W4387408075 hasConcept C62478195 @default.
- W4387408075 hasConcept C71924100 @default.
- W4387408075 hasConcept C86803240 @default.
- W4387408075 hasConcept C95444343 @default.
- W4387408075 hasConceptScore W4387408075C136834591 @default.
- W4387408075 hasConceptScore W4387408075C137620995 @default.
- W4387408075 hasConceptScore W4387408075C169760540 @default.
- W4387408075 hasConceptScore W4387408075C171056886 @default.
- W4387408075 hasConceptScore W4387408075C25498285 @default.
- W4387408075 hasConceptScore W4387408075C2780837183 @default.
- W4387408075 hasConceptScore W4387408075C28328180 @default.
- W4387408075 hasConceptScore W4387408075C62478195 @default.
- W4387408075 hasConceptScore W4387408075C71924100 @default.
- W4387408075 hasConceptScore W4387408075C86803240 @default.
- W4387408075 hasConceptScore W4387408075C95444343 @default.
- W4387408075 hasFunder F4320322120 @default.