Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387409890> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4387409890 endingPage "1813" @default.
- W4387409890 startingPage "1805" @default.
- W4387409890 abstract "The hypothesis stated here that, the long-term prevention by natural flavonoid phenolic compound, for example apigenin (Apg), improves baroreflex sensitivity and vascular resistance and occurs beneficial action for attenuation the renal hypertension (RH). One-kidney, 1-clip rats (1K1C) were treated with Apg for 2 weeks after 1 week of surgical intervention. At the end of the study in the control RH group the blood pressure (BP) increased on average by 43.5%, decreased in heart period (HP) by 9.8%, cardiochronotropic (vagal) component of baroreflex sensitivity (BRS) by 50%, and adrenergic component by 34%. Thus, in 1K1C experimental model of hypertension, provides switching to parasympathetic component and accompanied with proportionally nearly two-fold increase in epinephrine (EPN) and norepinephrine (NE) without changes in EPN/NE ratio. Morphometric changes in the kidney and heart confirmed the development of kidney and cardiac hypertrophy and renal functioning disturbances (blood urea nitrogen (BUN) increased in more than two-fold) and markers of sodium reabsorption in proximal tubule, total trans-EETs, decreased in 1.6-fold. The pronounced increased proinflammatory cytokines, interleukin 1b (IL1 b), endothelin -1 (ET-1) and tumor necrosis factor (TNF)-a confirmed the formation of “sterile inflammation” which strengthening by the nearly two-fold decreasing in the level of anti-inflammatory (vasodilatory) mediators, prostaglandin E2 (PGE2). Preventive long-term regime treatment with Apg (5mg/kg i.p./daily) in RH rats significantly decreased BP by 18.6%, increased parasympathetic component of BRS by 38.5% without marked altered its sympathetic component. Such deremodeling in BRS sensitivity associated with significant decreased in heart and kidney hypertrophy and functional activity of kidney, normalization of BUN and total EETs, reducing in circulating plasma level of catecholamines, and markedly attenuated progression of inflammation, decreased of proinflammatory levels of cytokines. Thus, Apg provides preventive beneficial pluripotent action in RH rats by exerting antihypertensive, cardio- and renoprotective effects and attenuation of “sterile inflammation”." @default.
- W4387409890 created "2023-10-07" @default.
- W4387409890 creator A5012452949 @default.
- W4387409890 creator A5014347317 @default.
- W4387409890 creator A5028916844 @default.
- W4387409890 creator A5046312608 @default.
- W4387409890 creator A5050344275 @default.
- W4387409890 creator A5060484843 @default.
- W4387409890 creator A5064196485 @default.
- W4387409890 creator A5090853884 @default.
- W4387409890 date "2023-09-30" @default.
- W4387409890 modified "2023-10-08" @default.
- W4387409890 title "Efficacy of Flavonoid Apigenin on Hemodynamic indices, Baroreflex Function, Cardiac and Kidney Remodeling and Vasoactive-Inflammatory Biomarkers in Experimental Renal Hypertension" @default.
- W4387409890 cites W1560497272 @default.
- W4387409890 cites W1978171593 @default.
- W4387409890 cites W1981099253 @default.
- W4387409890 cites W1998761430 @default.
- W4387409890 cites W2023553959 @default.
- W4387409890 cites W2024076076 @default.
- W4387409890 cites W2035455139 @default.
- W4387409890 cites W2103244635 @default.
- W4387409890 cites W2112327151 @default.
- W4387409890 cites W2125509715 @default.
- W4387409890 cites W2143085044 @default.
- W4387409890 cites W2148006981 @default.
- W4387409890 cites W2151369102 @default.
- W4387409890 cites W2198866495 @default.
- W4387409890 cites W2406180965 @default.
- W4387409890 cites W2602848944 @default.
- W4387409890 cites W2618861288 @default.
- W4387409890 cites W2789238333 @default.
- W4387409890 cites W2884668339 @default.
- W4387409890 cites W2912188831 @default.
- W4387409890 cites W2918230307 @default.
- W4387409890 cites W2980887471 @default.
- W4387409890 cites W2999666002 @default.
- W4387409890 cites W3013754122 @default.
- W4387409890 cites W3033631508 @default.
- W4387409890 cites W3130452549 @default.
- W4387409890 cites W3201187022 @default.
- W4387409890 cites W3207702107 @default.
- W4387409890 cites W4200099787 @default.
- W4387409890 cites W4211254834 @default.
- W4387409890 cites W4237788615 @default.
- W4387409890 cites W4309506523 @default.
- W4387409890 cites W4360611255 @default.
- W4387409890 doi "https://doi.org/10.13005/bpj/2760" @default.
- W4387409890 hasPublicationYear "2023" @default.
- W4387409890 type Work @default.
- W4387409890 citedByCount "0" @default.
- W4387409890 crossrefType "journal-article" @default.
- W4387409890 hasAuthorship W4387409890A5012452949 @default.
- W4387409890 hasAuthorship W4387409890A5014347317 @default.
- W4387409890 hasAuthorship W4387409890A5028916844 @default.
- W4387409890 hasAuthorship W4387409890A5046312608 @default.
- W4387409890 hasAuthorship W4387409890A5050344275 @default.
- W4387409890 hasAuthorship W4387409890A5060484843 @default.
- W4387409890 hasAuthorship W4387409890A5064196485 @default.
- W4387409890 hasAuthorship W4387409890A5090853884 @default.
- W4387409890 hasBestOaLocation W43874098901 @default.
- W4387409890 hasConcept C126322002 @default.
- W4387409890 hasConcept C134018914 @default.
- W4387409890 hasConcept C164027704 @default.
- W4387409890 hasConcept C191237925 @default.
- W4387409890 hasConcept C2776914184 @default.
- W4387409890 hasConcept C2777953023 @default.
- W4387409890 hasConcept C2780091579 @default.
- W4387409890 hasConcept C71924100 @default.
- W4387409890 hasConcept C84393581 @default.
- W4387409890 hasConceptScore W4387409890C126322002 @default.
- W4387409890 hasConceptScore W4387409890C134018914 @default.
- W4387409890 hasConceptScore W4387409890C164027704 @default.
- W4387409890 hasConceptScore W4387409890C191237925 @default.
- W4387409890 hasConceptScore W4387409890C2776914184 @default.
- W4387409890 hasConceptScore W4387409890C2777953023 @default.
- W4387409890 hasConceptScore W4387409890C2780091579 @default.
- W4387409890 hasConceptScore W4387409890C71924100 @default.
- W4387409890 hasConceptScore W4387409890C84393581 @default.
- W4387409890 hasIssue "3" @default.
- W4387409890 hasLocation W43874098901 @default.
- W4387409890 hasOpenAccess W4387409890 @default.
- W4387409890 hasPrimaryLocation W43874098901 @default.
- W4387409890 hasRelatedWork W1992848314 @default.
- W4387409890 hasRelatedWork W2099855370 @default.
- W4387409890 hasRelatedWork W2333595408 @default.
- W4387409890 hasRelatedWork W2392126385 @default.
- W4387409890 hasRelatedWork W2414563611 @default.
- W4387409890 hasRelatedWork W2416795054 @default.
- W4387409890 hasRelatedWork W2748952813 @default.
- W4387409890 hasRelatedWork W3022774229 @default.
- W4387409890 hasRelatedWork W3039146159 @default.
- W4387409890 hasRelatedWork W4379052364 @default.
- W4387409890 hasVolume "16" @default.
- W4387409890 isParatext "false" @default.
- W4387409890 isRetracted "false" @default.
- W4387409890 workType "article" @default.