Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387417611> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4387417611 endingPage "140" @default.
- W4387417611 startingPage "127" @default.
- W4387417611 abstract "Pyrazolones are a class of heterocyclic compounds that contain a pyrazole ring fused to a ketone group. Recent scientific research has focused extensively on the potential anti-inflammatory properties of pyrazolone compounds due to their diverse pharmacological effects in alleviating inflammation and reducing fever. This motivated us to focus on the preparation of these derivatives in a simple and eco-friendly manner. A convenient new green methodology was modified for the preparation of 1-phenyl-3,5-pyrazolidinedione by the sonicated MCR of diethyl malonate, phenylhydrazine, and a catalytic amount imidazole as homogenous organic catalyst in water green solvent in a good yield. On the other hand, some of 4-arylidinepyrazolidinedione derivatives are prepared in the same manner via the treatment of a mixture of diethyl malonate, phenylhydrazine, aromatic aldehydes, and a catalytic amount of imidazole in an aqueous medium. Our target synthesized pyrazolidinediones were elucidated via elemental and several spectral analyses. Due to the importance of pyrazolidinediones in the field of treating inflammation and relieving pain, a number of prepared compounds were chosen to test their efficacy as anti-inflammatory agents using carrageenan-induced foot edema in rats and compare the results with indomethacin, the standard drug. We found that the majority of derivatives yield promising results spanning from good to wonderful, so derivatives (15k, 15b, 15h, 15a, and 15j) yield the best results while derivative (15i) yields an average result. As for the derivative (15f), it yields the lowest results compared to the standard drug. This is due to the difference in the structural composition of these derivatives, which increases the likelihood of their use as anti-inflammatory derivatives." @default.
- W4387417611 created "2023-10-07" @default.
- W4387417611 creator A5013522892 @default.
- W4387417611 creator A5030738430 @default.
- W4387417611 creator A5032151011 @default.
- W4387417611 creator A5039730559 @default.
- W4387417611 creator A5047258036 @default.
- W4387417611 creator A5050073895 @default.
- W4387417611 creator A5055737952 @default.
- W4387417611 creator A5061257779 @default.
- W4387417611 creator A5062335149 @default.
- W4387417611 creator A5063582218 @default.
- W4387417611 creator A5077922009 @default.
- W4387417611 creator A5080912529 @default.
- W4387417611 date "2024-01-01" @default.
- W4387417611 modified "2023-10-12" @default.
- W4387417611 title "Multicomponent approach to the synthesis and spectral characterization of some 3,5-pyrazolididione derivatives and evaluation as anti-inflammatory agents" @default.
- W4387417611 cites W4387417611 @default.
- W4387417611 doi "https://doi.org/10.5267/j.ccl.2023.8.003" @default.
- W4387417611 hasPublicationYear "2024" @default.
- W4387417611 type Work @default.
- W4387417611 citedByCount "1" @default.
- W4387417611 crossrefType "journal-article" @default.
- W4387417611 hasAuthorship W4387417611A5013522892 @default.
- W4387417611 hasAuthorship W4387417611A5030738430 @default.
- W4387417611 hasAuthorship W4387417611A5032151011 @default.
- W4387417611 hasAuthorship W4387417611A5039730559 @default.
- W4387417611 hasAuthorship W4387417611A5047258036 @default.
- W4387417611 hasAuthorship W4387417611A5050073895 @default.
- W4387417611 hasAuthorship W4387417611A5055737952 @default.
- W4387417611 hasAuthorship W4387417611A5061257779 @default.
- W4387417611 hasAuthorship W4387417611A5062335149 @default.
- W4387417611 hasAuthorship W4387417611A5063582218 @default.
- W4387417611 hasAuthorship W4387417611A5077922009 @default.
- W4387417611 hasAuthorship W4387417611A5080912529 @default.
- W4387417611 hasBestOaLocation W43874176111 @default.
- W4387417611 hasConcept C134121241 @default.
- W4387417611 hasConcept C161790260 @default.
- W4387417611 hasConcept C178790620 @default.
- W4387417611 hasConcept C185592680 @default.
- W4387417611 hasConcept C191897082 @default.
- W4387417611 hasConcept C192562407 @default.
- W4387417611 hasConcept C2776098391 @default.
- W4387417611 hasConcept C2776967830 @default.
- W4387417611 hasConcept C2777682936 @default.
- W4387417611 hasConcept C2778802955 @default.
- W4387417611 hasConcept C2780513484 @default.
- W4387417611 hasConcept C2780874372 @default.
- W4387417611 hasConcept C2908653458 @default.
- W4387417611 hasConceptScore W4387417611C134121241 @default.
- W4387417611 hasConceptScore W4387417611C161790260 @default.
- W4387417611 hasConceptScore W4387417611C178790620 @default.
- W4387417611 hasConceptScore W4387417611C185592680 @default.
- W4387417611 hasConceptScore W4387417611C191897082 @default.
- W4387417611 hasConceptScore W4387417611C192562407 @default.
- W4387417611 hasConceptScore W4387417611C2776098391 @default.
- W4387417611 hasConceptScore W4387417611C2776967830 @default.
- W4387417611 hasConceptScore W4387417611C2777682936 @default.
- W4387417611 hasConceptScore W4387417611C2778802955 @default.
- W4387417611 hasConceptScore W4387417611C2780513484 @default.
- W4387417611 hasConceptScore W4387417611C2780874372 @default.
- W4387417611 hasConceptScore W4387417611C2908653458 @default.
- W4387417611 hasIssue "1" @default.
- W4387417611 hasLocation W43874176111 @default.
- W4387417611 hasOpenAccess W4387417611 @default.
- W4387417611 hasPrimaryLocation W43874176111 @default.
- W4387417611 hasRelatedWork W1971127514 @default.
- W4387417611 hasRelatedWork W1972131152 @default.
- W4387417611 hasRelatedWork W2004421577 @default.
- W4387417611 hasRelatedWork W2025508928 @default.
- W4387417611 hasRelatedWork W2059382239 @default.
- W4387417611 hasRelatedWork W2060381715 @default.
- W4387417611 hasRelatedWork W2092556399 @default.
- W4387417611 hasRelatedWork W2285474064 @default.
- W4387417611 hasRelatedWork W2331858600 @default.
- W4387417611 hasRelatedWork W4235265576 @default.
- W4387417611 hasVolume "13" @default.
- W4387417611 isParatext "false" @default.
- W4387417611 isRetracted "false" @default.
- W4387417611 workType "article" @default.