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• W4387419366 endingPage "115532" @default.
• W4387419366 startingPage "115532" @default.
• W4387419366 abstract "Benzene poisoning can cause acute myeloid leukemia (AML) through a variety of passways. Tim-3 has gained prominence as a potential candidate in mediating immunosuppression in tumor microenvironments. The macrophage polarization is also related to immune escape. Herein, we reported that Tim-3 and macrophage M2 polarization play a vital role in benzene-induced AML. First, the benzene-induced AML C3H/He mouse model was constructed by subcutaneously injecting 250 mg/kg of benzene. After six months, macrophage phenotype, cytokines, and Tim-3 expression levels were investigated. Flow cytometry assay revealed that the T-cell inhibitory receptor Tim-3 was significantly upregulated in both bone marrow and spleen of the benzene-induced AML mouse model. Elisa's results displayed a decreased serum level of IL-12 while increased TGF-β1. Mechanistically, changes in cytokine secretion promote the growth of M2-type macrophages in the bone marrow and spleen, as determined by immunofluorescence assay. The increased levels of PI3K, AKT, and mTOR in the benzene-exposure group further proved the crucial role of Tim-3 in regulating the functional status of macrophages in the AML microenvironment. These results demonstrate that Tim-3 and macrophage polarization may play a vital role during the immune escape of the benzene-induced AML. This study provides a new potential intervention site for immune checkpoint-based AML therapeutic strategy." @default.
• W4387419366 created "2023-10-07" @default.
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• W4387419366 date "2023-11-01" @default.
• W4387419366 modified "2023-10-14" @default.
• W4387419366 title "Tim-3 facilitates immune escape in benzene-induced acute myeloid leukemia mouse model by promoting macrophage M2 polarization" @default.
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• W4387419366 doi "https://doi.org/10.1016/j.ecoenv.2023.115532" @default.
• W4387419366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37806131" @default.
• W4387419366 hasPublicationYear "2023" @default.
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