Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387420605> ?p ?o ?g. }
- W4387420605 abstract "Abstract A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In addition to mediators of age‐related pathology, components of the senescence associated secretory phenotype (SASP) have been studied as biomarkers of senescent cell burden and, in turn, biological age. Therefore, we hypothesized that circulating concentrations of candidate senescence biomarkers, including chemokines, cytokines, matrix remodeling proteins, and growth factors, could predict mortality in older adults. We assessed associations between plasma levels of 28 SASP proteins and risk of mortality over a median follow‐up of 6.3 years in 1923 patients 65 years of age or older with zero or one chronic condition at baseline. Overall, the five senescence biomarkers most strongly associated with an increased risk of death were GDF15, RAGE, VEGFA, PARC, and MMP2, after adjusting for age, sex, race, and the presence of one chronic condition. The combination of biomarkers and clinical and demographic covariates exhibited a significantly higher c‐statistic for risk of death (0.79, 95% confidence interval (CI): 0.76–0.82) than the covariates alone (0.70, CI: 0.67–0.74) ( p < 0.001). Collectively, these findings lend further support to biomarkers of cellular senescence as informative predictors of clinically important health outcomes in older adults, including death." @default.
- W4387420605 created "2023-10-08" @default.
- W4387420605 creator A5006997452 @default.
- W4387420605 creator A5014342029 @default.
- W4387420605 creator A5030579684 @default.
- W4387420605 creator A5038589760 @default.
- W4387420605 creator A5041091292 @default.
- W4387420605 creator A5044875947 @default.
- W4387420605 creator A5049778012 @default.
- W4387420605 creator A5063933818 @default.
- W4387420605 creator A5073303043 @default.
- W4387420605 creator A5077697121 @default.
- W4387420605 creator A5088395323 @default.
- W4387420605 creator A5088502721 @default.
- W4387420605 creator A5088736025 @default.
- W4387420605 creator A5091800109 @default.
- W4387420605 date "2023-10-06" @default.
- W4387420605 modified "2023-10-13" @default.
- W4387420605 title "Biomarkers of cellular senescence and risk of death in humans" @default.
- W4387420605 cites W1758822526 @default.
- W4387420605 cites W1992039515 @default.
- W4387420605 cites W2006775589 @default.
- W4387420605 cites W2055223329 @default.
- W4387420605 cites W2058647415 @default.
- W4387420605 cites W2073714833 @default.
- W4387420605 cites W2105125376 @default.
- W4387420605 cites W2112868039 @default.
- W4387420605 cites W2114177120 @default.
- W4387420605 cites W2148715056 @default.
- W4387420605 cites W2467271588 @default.
- W4387420605 cites W2591114726 @default.
- W4387420605 cites W2783817290 @default.
- W4387420605 cites W2803490690 @default.
- W4387420605 cites W2883061610 @default.
- W4387420605 cites W2912918280 @default.
- W4387420605 cites W2927899822 @default.
- W4387420605 cites W2950334869 @default.
- W4387420605 cites W29873225 @default.
- W4387420605 cites W3002676854 @default.
- W4387420605 cites W3019970601 @default.
- W4387420605 cites W3026163675 @default.
- W4387420605 cites W3036659787 @default.
- W4387420605 cites W3045067389 @default.
- W4387420605 cites W3141186490 @default.
- W4387420605 cites W3148132672 @default.
- W4387420605 cites W4307280734 @default.
- W4387420605 cites W4313419476 @default.
- W4387420605 doi "https://doi.org/10.1111/acel.14006" @default.
- W4387420605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37803875" @default.
- W4387420605 hasPublicationYear "2023" @default.
- W4387420605 type Work @default.
- W4387420605 citedByCount "0" @default.
- W4387420605 crossrefType "journal-article" @default.
- W4387420605 hasAuthorship W4387420605A5006997452 @default.
- W4387420605 hasAuthorship W4387420605A5014342029 @default.
- W4387420605 hasAuthorship W4387420605A5030579684 @default.
- W4387420605 hasAuthorship W4387420605A5038589760 @default.
- W4387420605 hasAuthorship W4387420605A5041091292 @default.
- W4387420605 hasAuthorship W4387420605A5044875947 @default.
- W4387420605 hasAuthorship W4387420605A5049778012 @default.
- W4387420605 hasAuthorship W4387420605A5063933818 @default.
- W4387420605 hasAuthorship W4387420605A5073303043 @default.
- W4387420605 hasAuthorship W4387420605A5077697121 @default.
- W4387420605 hasAuthorship W4387420605A5088395323 @default.
- W4387420605 hasAuthorship W4387420605A5088502721 @default.
- W4387420605 hasAuthorship W4387420605A5088736025 @default.
- W4387420605 hasAuthorship W4387420605A5091800109 @default.
- W4387420605 hasBestOaLocation W43874206051 @default.
- W4387420605 hasConcept C126322002 @default.
- W4387420605 hasConcept C143998085 @default.
- W4387420605 hasConcept C203014093 @default.
- W4387420605 hasConcept C2779134260 @default.
- W4387420605 hasConcept C2781197716 @default.
- W4387420605 hasConcept C44249647 @default.
- W4387420605 hasConcept C522857546 @default.
- W4387420605 hasConcept C54355233 @default.
- W4387420605 hasConcept C60644358 @default.
- W4387420605 hasConcept C71924100 @default.
- W4387420605 hasConcept C86803240 @default.
- W4387420605 hasConceptScore W4387420605C126322002 @default.
- W4387420605 hasConceptScore W4387420605C143998085 @default.
- W4387420605 hasConceptScore W4387420605C203014093 @default.
- W4387420605 hasConceptScore W4387420605C2779134260 @default.
- W4387420605 hasConceptScore W4387420605C2781197716 @default.
- W4387420605 hasConceptScore W4387420605C44249647 @default.
- W4387420605 hasConceptScore W4387420605C522857546 @default.
- W4387420605 hasConceptScore W4387420605C54355233 @default.
- W4387420605 hasConceptScore W4387420605C60644358 @default.
- W4387420605 hasConceptScore W4387420605C71924100 @default.
- W4387420605 hasConceptScore W4387420605C86803240 @default.
- W4387420605 hasFunder F4320332605 @default.
- W4387420605 hasFunder F4320337337 @default.
- W4387420605 hasLocation W43874206051 @default.
- W4387420605 hasLocation W43874206052 @default.
- W4387420605 hasOpenAccess W4387420605 @default.
- W4387420605 hasPrimaryLocation W43874206051 @default.
- W4387420605 hasRelatedWork W2037680056 @default.
- W4387420605 hasRelatedWork W2059729414 @default.
- W4387420605 hasRelatedWork W2077241234 @default.
- W4387420605 hasRelatedWork W2162414118 @default.