Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387421256> ?p ?o ?g. }
- W4387421256 endingPage "2716" @default.
- W4387421256 startingPage "2716" @default.
- W4387421256 abstract "Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure found in nature and enabling synthesis under laboratory conditions. Among the series of synthesized and tested oxazine–pyrimidine and piperazine–pyrimidine derivatives, compounds 3a and 5b inhibited breast cancer cell (MCF–7) viability with an IC50 value of 9.17 and 6.29 µM, respectively. In silico docking studies showed that the pyrimidine ring of 3a and the 4–methoxybenzyl thiol group of 5b could strongly bind the p65 subunit of NF–κB, with the binding energies −9.32 and −7.32 kcal mol−1. Furthermore, compounds 3a and 5b inhibited NF–κB in MCF–7 breast cancer cells. In conclusion, we herein report newer structures that target NF–κB in BC cells." @default.
- W4387421256 created "2023-10-08" @default.
- W4387421256 creator A5008372146 @default.
- W4387421256 creator A5017758464 @default.
- W4387421256 creator A5021327644 @default.
- W4387421256 creator A5029933260 @default.
- W4387421256 creator A5032929926 @default.
- W4387421256 creator A5037236595 @default.
- W4387421256 creator A5047044401 @default.
- W4387421256 creator A5050519849 @default.
- W4387421256 creator A5051119189 @default.
- W4387421256 creator A5068418256 @default.
- W4387421256 creator A5082166940 @default.
- W4387421256 date "2023-10-06" @default.
- W4387421256 modified "2023-10-18" @default.
- W4387421256 title "Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells" @default.
- W4387421256 cites W1992241296 @default.
- W4387421256 cites W1996646278 @default.
- W4387421256 cites W2000601138 @default.
- W4387421256 cites W2010237936 @default.
- W4387421256 cites W2020364086 @default.
- W4387421256 cites W2037690301 @default.
- W4387421256 cites W2058521000 @default.
- W4387421256 cites W2074688366 @default.
- W4387421256 cites W2081161751 @default.
- W4387421256 cites W2086008721 @default.
- W4387421256 cites W2086474508 @default.
- W4387421256 cites W2088094960 @default.
- W4387421256 cites W2097884661 @default.
- W4387421256 cites W2124343538 @default.
- W4387421256 cites W2132629607 @default.
- W4387421256 cites W2165526004 @default.
- W4387421256 cites W2336702018 @default.
- W4387421256 cites W2525431899 @default.
- W4387421256 cites W2574819148 @default.
- W4387421256 cites W2770341053 @default.
- W4387421256 cites W2890743393 @default.
- W4387421256 cites W2911188335 @default.
- W4387421256 cites W2911341099 @default.
- W4387421256 cites W2913601537 @default.
- W4387421256 cites W3008274095 @default.
- W4387421256 cites W3010714596 @default.
- W4387421256 cites W3017485716 @default.
- W4387421256 cites W3020558783 @default.
- W4387421256 cites W3044714181 @default.
- W4387421256 cites W3044908787 @default.
- W4387421256 cites W3129158050 @default.
- W4387421256 cites W3158113378 @default.
- W4387421256 cites W3164508239 @default.
- W4387421256 cites W3175592930 @default.
- W4387421256 cites W4225114605 @default.
- W4387421256 cites W4293721645 @default.
- W4387421256 cites W4300690596 @default.
- W4387421256 cites W4312200847 @default.
- W4387421256 cites W4362607811 @default.
- W4387421256 doi "https://doi.org/10.3390/biomedicines11102716" @default.
- W4387421256 hasPublicationYear "2023" @default.
- W4387421256 type Work @default.
- W4387421256 citedByCount "0" @default.
- W4387421256 crossrefType "journal-article" @default.
- W4387421256 hasAuthorship W4387421256A5008372146 @default.
- W4387421256 hasAuthorship W4387421256A5017758464 @default.
- W4387421256 hasAuthorship W4387421256A5021327644 @default.
- W4387421256 hasAuthorship W4387421256A5029933260 @default.
- W4387421256 hasAuthorship W4387421256A5032929926 @default.
- W4387421256 hasAuthorship W4387421256A5037236595 @default.
- W4387421256 hasAuthorship W4387421256A5047044401 @default.
- W4387421256 hasAuthorship W4387421256A5050519849 @default.
- W4387421256 hasAuthorship W4387421256A5051119189 @default.
- W4387421256 hasAuthorship W4387421256A5068418256 @default.
- W4387421256 hasAuthorship W4387421256A5082166940 @default.
- W4387421256 hasBestOaLocation W43874212561 @default.
- W4387421256 hasConcept C104292427 @default.
- W4387421256 hasConcept C104317684 @default.
- W4387421256 hasConcept C109541995 @default.
- W4387421256 hasConcept C121608353 @default.
- W4387421256 hasConcept C126322002 @default.
- W4387421256 hasConcept C159110408 @default.
- W4387421256 hasConcept C178790620 @default.
- W4387421256 hasConcept C185592680 @default.
- W4387421256 hasConcept C2775905019 @default.
- W4387421256 hasConcept C2776201271 @default.
- W4387421256 hasConcept C2777730290 @default.
- W4387421256 hasConcept C2779321679 @default.
- W4387421256 hasConcept C2994423619 @default.
- W4387421256 hasConcept C41685203 @default.
- W4387421256 hasConcept C502942594 @default.
- W4387421256 hasConcept C530470458 @default.
- W4387421256 hasConcept C55493867 @default.
- W4387421256 hasConcept C62478195 @default.
- W4387421256 hasConcept C71240020 @default.
- W4387421256 hasConcept C71924100 @default.
- W4387421256 hasConcept C86803240 @default.
- W4387421256 hasConcept C96232424 @default.
- W4387421256 hasConceptScore W4387421256C104292427 @default.
- W4387421256 hasConceptScore W4387421256C104317684 @default.
- W4387421256 hasConceptScore W4387421256C109541995 @default.
- W4387421256 hasConceptScore W4387421256C121608353 @default.