Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387421480> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4387421480 abstract "Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits, and some variants are shown to be associated with multiple complex traits. Genetic covariance between two traits is defined as the underlying covariance of genetic effects and can be used to measure the shared genetic architecture. The data used to estimate such a genetic covariance can be from the same group or different groups of individuals, and the traits can be of different types or collected based on different study designs. This paper proposes a unified regression-based approach to robust estimation and inference for genetic covariance of general traits that may be associated with genetic variants nonlinearly. The asymptotic properties of the proposed estimator are provided and are shown to be robust under certain model mis-specification. Our method under linear working models provides a robust inference for the narrow-sense genetic covariance, even when both linear models are mis-specified. Numerical experiments are performed to support the theoretical results. Our method is applied to an outbred mice GWAS data set to study the overlapping genetic effects between the behavioral and physiological phenotypes. The real data results reveal interesting genetic covariance among different mice developmental traits." @default.
- W4387421480 created "2023-10-08" @default.
- W4387421480 creator A5005688217 @default.
- W4387421480 creator A5034848206 @default.
- W4387421480 creator A5082318113 @default.
- W4387421480 date "2021-06-08" @default.
- W4387421480 modified "2023-10-18" @default.
- W4387421480 title "A Regression-based Approach to Robust Estimation and Inference for Genetic Covariance" @default.
- W4387421480 doi "https://doi.org/10.48550/arxiv.2106.04106" @default.
- W4387421480 hasPublicationYear "2021" @default.
- W4387421480 type Work @default.
- W4387421480 citedByCount "0" @default.
- W4387421480 crossrefType "posted-content" @default.
- W4387421480 hasAuthorship W4387421480A5005688217 @default.
- W4387421480 hasAuthorship W4387421480A5034848206 @default.
- W4387421480 hasAuthorship W4387421480A5082318113 @default.
- W4387421480 hasBestOaLocation W43874214801 @default.
- W4387421480 hasConcept C104317684 @default.
- W4387421480 hasConcept C105795698 @default.
- W4387421480 hasConcept C106208931 @default.
- W4387421480 hasConcept C135763542 @default.
- W4387421480 hasConcept C153209595 @default.
- W4387421480 hasConcept C154945302 @default.
- W4387421480 hasConcept C163175372 @default.
- W4387421480 hasConcept C178650346 @default.
- W4387421480 hasConcept C180877172 @default.
- W4387421480 hasConcept C185429906 @default.
- W4387421480 hasConcept C2776214188 @default.
- W4387421480 hasConcept C33923547 @default.
- W4387421480 hasConcept C41008148 @default.
- W4387421480 hasConcept C54355233 @default.
- W4387421480 hasConcept C81941488 @default.
- W4387421480 hasConcept C83546350 @default.
- W4387421480 hasConcept C86803240 @default.
- W4387421480 hasConcept C9287583 @default.
- W4387421480 hasConceptScore W4387421480C104317684 @default.
- W4387421480 hasConceptScore W4387421480C105795698 @default.
- W4387421480 hasConceptScore W4387421480C106208931 @default.
- W4387421480 hasConceptScore W4387421480C135763542 @default.
- W4387421480 hasConceptScore W4387421480C153209595 @default.
- W4387421480 hasConceptScore W4387421480C154945302 @default.
- W4387421480 hasConceptScore W4387421480C163175372 @default.
- W4387421480 hasConceptScore W4387421480C178650346 @default.
- W4387421480 hasConceptScore W4387421480C180877172 @default.
- W4387421480 hasConceptScore W4387421480C185429906 @default.
- W4387421480 hasConceptScore W4387421480C2776214188 @default.
- W4387421480 hasConceptScore W4387421480C33923547 @default.
- W4387421480 hasConceptScore W4387421480C41008148 @default.
- W4387421480 hasConceptScore W4387421480C54355233 @default.
- W4387421480 hasConceptScore W4387421480C81941488 @default.
- W4387421480 hasConceptScore W4387421480C83546350 @default.
- W4387421480 hasConceptScore W4387421480C86803240 @default.
- W4387421480 hasConceptScore W4387421480C9287583 @default.
- W4387421480 hasLocation W43874214801 @default.
- W4387421480 hasOpenAccess W4387421480 @default.
- W4387421480 hasPrimaryLocation W43874214801 @default.
- W4387421480 hasRelatedWork W2126916073 @default.
- W4387421480 hasRelatedWork W2142550298 @default.
- W4387421480 hasRelatedWork W2754869062 @default.
- W4387421480 hasRelatedWork W2923859939 @default.
- W4387421480 hasRelatedWork W2982417329 @default.
- W4387421480 hasRelatedWork W2986919234 @default.
- W4387421480 hasRelatedWork W3098014387 @default.
- W4387421480 hasRelatedWork W3195469724 @default.
- W4387421480 hasRelatedWork W4210605760 @default.
- W4387421480 hasRelatedWork W4363648506 @default.
- W4387421480 isParatext "false" @default.
- W4387421480 isRetracted "false" @default.
- W4387421480 workType "article" @default.