Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387422728> ?p ?o ?g. }
- W4387422728 endingPage "14966" @default.
- W4387422728 startingPage "14966" @default.
- W4387422728 abstract "Bacteria readily acquire resistance to traditional antibiotics, resulting in pan-resistant strains with no available treatment. Antimicrobial resistance is a global challenge and without the development of effective antimicrobials, the foundation of modern medicine is at risk. Combination therapies such as antibiotic-antibiotic and antibiotic-adjuvant combinations are strategies used to combat antibiotic resistance. Current research focuses on antimicrobial peptidomimetics as adjuvant compounds, due to their promising activity against antibiotic-resistant bacteria. Here, for the first time we demonstrate that antibiotic-peptidomimetic combinations mitigate the development of antibiotic resistance in Staphylococcus aureus and Pseudomonas aeruginosa. When ciprofloxacin and gentamicin were passaged individually at sub-inhibitory concentrations for 10 days, the minimum inhibitory concentrations (MICs) increased up to 32-fold and 128-fold for S. aureus and P. aeruginosa, respectively. In contrast, when antibiotics were passaged in combination with peptidomimetics (Melimine, Mel4, RK758), the MICs of both antibiotics and peptidomimetics remained constant, indicating these combinations were able to mitigate the development of antibiotic-resistance. Furthermore, antibiotic-peptidomimetic combinations demonstrated synergistic activity against both Gram-positive and Gram-negative bacteria, reducing the concentration needed for bactericidal activity. This has significant potential clinical applications-including preventing the spread of antibiotic-resistant strains in hospitals and communities, reviving ineffective antibiotics, and lowering the toxicity of antimicrobial chemotherapy." @default.
- W4387422728 created "2023-10-08" @default.
- W4387422728 creator A5017276071 @default.
- W4387422728 creator A5021644216 @default.
- W4387422728 creator A5042129724 @default.
- W4387422728 creator A5054628624 @default.
- W4387422728 creator A5060204487 @default.
- W4387422728 creator A5061837629 @default.
- W4387422728 creator A5075971518 @default.
- W4387422728 date "2023-10-06" @default.
- W4387422728 modified "2023-10-18" @default.
- W4387422728 title "Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria" @default.
- W4387422728 cites W1524711975 @default.
- W4387422728 cites W1576533924 @default.
- W4387422728 cites W1988340005 @default.
- W4387422728 cites W1997152791 @default.
- W4387422728 cites W2009671723 @default.
- W4387422728 cites W2042760907 @default.
- W4387422728 cites W2044838012 @default.
- W4387422728 cites W2050895876 @default.
- W4387422728 cites W2054602599 @default.
- W4387422728 cites W2059542558 @default.
- W4387422728 cites W2064938254 @default.
- W4387422728 cites W2065362106 @default.
- W4387422728 cites W2067778091 @default.
- W4387422728 cites W2068188419 @default.
- W4387422728 cites W2074221599 @default.
- W4387422728 cites W2093459863 @default.
- W4387422728 cites W2102672963 @default.
- W4387422728 cites W2133603290 @default.
- W4387422728 cites W2155553922 @default.
- W4387422728 cites W2163489100 @default.
- W4387422728 cites W2288616517 @default.
- W4387422728 cites W2316777574 @default.
- W4387422728 cites W2466283077 @default.
- W4387422728 cites W2496848599 @default.
- W4387422728 cites W2515497383 @default.
- W4387422728 cites W2522406682 @default.
- W4387422728 cites W2556828189 @default.
- W4387422728 cites W2588436517 @default.
- W4387422728 cites W2731981206 @default.
- W4387422728 cites W2749055920 @default.
- W4387422728 cites W2751994003 @default.
- W4387422728 cites W2802068594 @default.
- W4387422728 cites W2810727101 @default.
- W4387422728 cites W2890686817 @default.
- W4387422728 cites W2896498791 @default.
- W4387422728 cites W2898519775 @default.
- W4387422728 cites W2900825145 @default.
- W4387422728 cites W2911665973 @default.
- W4387422728 cites W2912247484 @default.
- W4387422728 cites W2932727494 @default.
- W4387422728 cites W2947447072 @default.
- W4387422728 cites W2964809094 @default.
- W4387422728 cites W2969491178 @default.
- W4387422728 cites W297741533 @default.
- W4387422728 cites W3001428210 @default.
- W4387422728 cites W3011719258 @default.
- W4387422728 cites W3015415777 @default.
- W4387422728 cites W3025476698 @default.
- W4387422728 cites W3036187415 @default.
- W4387422728 cites W3086284165 @default.
- W4387422728 cites W3088313863 @default.
- W4387422728 cites W3095018596 @default.
- W4387422728 cites W3095869439 @default.
- W4387422728 cites W3096605848 @default.
- W4387422728 cites W3112550700 @default.
- W4387422728 cites W3163424606 @default.
- W4387422728 cites W3174694073 @default.
- W4387422728 cites W3195351580 @default.
- W4387422728 cites W3201979232 @default.
- W4387422728 cites W3207626967 @default.
- W4387422728 cites W3213437468 @default.
- W4387422728 cites W4220919787 @default.
- W4387422728 cites W4229377593 @default.
- W4387422728 cites W4282942734 @default.
- W4387422728 cites W4289878552 @default.
- W4387422728 cites W4291991981 @default.
- W4387422728 cites W4292184999 @default.
- W4387422728 cites W4295762030 @default.
- W4387422728 doi "https://doi.org/10.3390/ijms241914966" @default.
- W4387422728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37834415" @default.
- W4387422728 hasPublicationYear "2023" @default.
- W4387422728 type Work @default.
- W4387422728 citedByCount "0" @default.
- W4387422728 crossrefType "journal-article" @default.
- W4387422728 hasAuthorship W4387422728A5017276071 @default.
- W4387422728 hasAuthorship W4387422728A5021644216 @default.
- W4387422728 hasAuthorship W4387422728A5042129724 @default.
- W4387422728 hasAuthorship W4387422728A5054628624 @default.
- W4387422728 hasAuthorship W4387422728A5060204487 @default.
- W4387422728 hasAuthorship W4387422728A5061837629 @default.
- W4387422728 hasAuthorship W4387422728A5075971518 @default.
- W4387422728 hasBestOaLocation W43874227281 @default.
- W4387422728 hasConcept C124790011 @default.
- W4387422728 hasConcept C2775832221 @default.
- W4387422728 hasConcept C2777637488 @default.
- W4387422728 hasConcept C2778512257 @default.