Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387424229> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4387424229 endingPage "345" @default.
- W4387424229 startingPage "339" @default.
- W4387424229 abstract "Silymarin was shown to enhance diclofenac toxicity by inducing the loss of mitochondrial membrane permeability (MMP) in Caco-2 cells, independent of endoplasmic reticulum stress. This study employed in silico molecular docking to further investigate the potential interaction between silymarin and specific mitochondrial proteins involved in the loss of mitochondria integrity, aiming to elucidate the underlying mechanism of potentiation. The target proteins for our docking analysis included mitochondrial complex I and III, voltage-dependent anion-selective channel (VDAC), and cyclophilin D (CypD). Our results indicated that diclofenac could bind to both mitochondrial complex I and III. In contrast, silymarin exhibited a strong interaction with mitochondrial complex I with the binding energy (ΔG) -7.74 kcal/mol and the inhibition constant (Ki) 2.12 µM, while not showing significant interaction with mitochondrial complex III. Additionally, silymarin had the potential to induce the opening of mitochondrial permeability transition pore by binding with VDAC in the outer mitochondrial membrane with ΔG -6.08 kcal/mol and Ki 34.94 µM. However, silymarin did not exhibit significant interaction with CypD in the inner mitochondrial membrane. Therefore, mitochondrial complex I and VDAC could be the potentiation targets of silymarin, resulting in the disruption of mitochondria integrity and enhancing the toxicity of diclofenac." @default.
- W4387424229 created "2023-10-08" @default.
- W4387424229 creator A5030702440 @default.
- W4387424229 creator A5049161497 @default.
- W4387424229 date "2023-12-01" @default.
- W4387424229 modified "2023-10-18" @default.
- W4387424229 title "Predicting molecular mechanism of silymarin-potentiated diclofenac toxicity: Insight from in silico molecular docking" @default.
- W4387424229 cites W2010897060 @default.
- W4387424229 cites W2516047307 @default.
- W4387424229 cites W2553902009 @default.
- W4387424229 cites W2745371978 @default.
- W4387424229 cites W2772755903 @default.
- W4387424229 cites W2914578369 @default.
- W4387424229 cites W2922846941 @default.
- W4387424229 cites W2925894164 @default.
- W4387424229 cites W2944379014 @default.
- W4387424229 cites W2993300549 @default.
- W4387424229 cites W2999266339 @default.
- W4387424229 cites W3003273489 @default.
- W4387424229 cites W3003356608 @default.
- W4387424229 cites W3033656382 @default.
- W4387424229 cites W3044309478 @default.
- W4387424229 cites W4200051192 @default.
- W4387424229 cites W4206907823 @default.
- W4387424229 cites W4221063021 @default.
- W4387424229 cites W4288423677 @default.
- W4387424229 cites W4310172111 @default.
- W4387424229 doi "https://doi.org/10.1016/j.toxrep.2023.10.001" @default.
- W4387424229 hasPublicationYear "2023" @default.
- W4387424229 type Work @default.
- W4387424229 citedByCount "0" @default.
- W4387424229 crossrefType "journal-article" @default.
- W4387424229 hasAuthorship W4387424229A5030702440 @default.
- W4387424229 hasAuthorship W4387424229A5049161497 @default.
- W4387424229 hasBestOaLocation W43874242291 @default.
- W4387424229 hasConcept C104317684 @default.
- W4387424229 hasConcept C12554922 @default.
- W4387424229 hasConcept C13591479 @default.
- W4387424229 hasConcept C146587185 @default.
- W4387424229 hasConcept C158617107 @default.
- W4387424229 hasConcept C159110408 @default.
- W4387424229 hasConcept C185592680 @default.
- W4387424229 hasConcept C190283241 @default.
- W4387424229 hasConcept C200784783 @default.
- W4387424229 hasConcept C2775905019 @default.
- W4387424229 hasConcept C28859421 @default.
- W4387424229 hasConcept C31573885 @default.
- W4387424229 hasConcept C41685203 @default.
- W4387424229 hasConcept C547475151 @default.
- W4387424229 hasConcept C55493867 @default.
- W4387424229 hasConcept C71924100 @default.
- W4387424229 hasConcept C74897846 @default.
- W4387424229 hasConcept C75385678 @default.
- W4387424229 hasConcept C86803240 @default.
- W4387424229 hasConcept C95444343 @default.
- W4387424229 hasConceptScore W4387424229C104317684 @default.
- W4387424229 hasConceptScore W4387424229C12554922 @default.
- W4387424229 hasConceptScore W4387424229C13591479 @default.
- W4387424229 hasConceptScore W4387424229C146587185 @default.
- W4387424229 hasConceptScore W4387424229C158617107 @default.
- W4387424229 hasConceptScore W4387424229C159110408 @default.
- W4387424229 hasConceptScore W4387424229C185592680 @default.
- W4387424229 hasConceptScore W4387424229C190283241 @default.
- W4387424229 hasConceptScore W4387424229C200784783 @default.
- W4387424229 hasConceptScore W4387424229C2775905019 @default.
- W4387424229 hasConceptScore W4387424229C28859421 @default.
- W4387424229 hasConceptScore W4387424229C31573885 @default.
- W4387424229 hasConceptScore W4387424229C41685203 @default.
- W4387424229 hasConceptScore W4387424229C547475151 @default.
- W4387424229 hasConceptScore W4387424229C55493867 @default.
- W4387424229 hasConceptScore W4387424229C71924100 @default.
- W4387424229 hasConceptScore W4387424229C74897846 @default.
- W4387424229 hasConceptScore W4387424229C75385678 @default.
- W4387424229 hasConceptScore W4387424229C86803240 @default.
- W4387424229 hasConceptScore W4387424229C95444343 @default.
- W4387424229 hasFunder F4320321557 @default.
- W4387424229 hasFunder F4320329659 @default.
- W4387424229 hasLocation W43874242291 @default.
- W4387424229 hasOpenAccess W4387424229 @default.
- W4387424229 hasPrimaryLocation W43874242291 @default.
- W4387424229 hasRelatedWork W1480250753 @default.
- W4387424229 hasRelatedWork W1980959570 @default.
- W4387424229 hasRelatedWork W1994442108 @default.
- W4387424229 hasRelatedWork W2015990527 @default.
- W4387424229 hasRelatedWork W2042584010 @default.
- W4387424229 hasRelatedWork W2079781432 @default.
- W4387424229 hasRelatedWork W2156861743 @default.
- W4387424229 hasRelatedWork W2386688179 @default.
- W4387424229 hasRelatedWork W2584152658 @default.
- W4387424229 hasRelatedWork W4206907823 @default.
- W4387424229 hasVolume "11" @default.
- W4387424229 isParatext "false" @default.
- W4387424229 isRetracted "false" @default.
- W4387424229 workType "article" @default.