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- W4387424240 abstract "People living with HIV (PLWH) are prone to developing tuberculosis (TB). Since tenofovir alafenamide (TAF) is the recommended tenofovir (TFV) prodrug and rifampicin is a key component of TB therapy, thus complicating HIV and TB coinfection management. However, there is little data regarding the impact of this drug-drug Interaction in PLWH, which makes health care providers reluctant to prescribe them together. This was an observational, retrospective case series carried out in the King Faisal Specialist Hospital & Research Centre (KFSH&RC), Jeddah, Saudi Arabia. PLWH (≥18 years old) who received the TAF-containing ARV regimen and rifampicin-based anti-TB therapy together for ≥ 4 weeks were included. The objective of this study was to report the clinical impact of this drug-drug interaction (rifampicin + TAF-containing antiretroviral (ARV) regimen) on HIV viral load control in PLWH. A total of 7 PLWH who met the inclusion criteria, 5 (71%) out of 7, were males. All patients received dolutegravir 50 mg twice daily (DTG) plus the combination of TAF 25 mg and emtricitabine 200 mg (FTC) once daily as their ARV regimen. Four patients had suppressed viral load levels at baseline, which was maintained throughout TB treatment. Three patients had unsuppressed viral load levels at baseline and attained viral load suppression throughout the TB treatment course Overall, the TAF-containing ARV regimen maintained its efficacy in presence of rifampicin." @default.
- W4387424240 created "2023-10-08" @default.
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- W4387424240 date "2023-10-01" @default.
- W4387424240 modified "2023-10-18" @default.
- W4387424240 title "The Clinical Impact of Rifampicin-Based Anti-TB Therapy and Tenofovir Alafenamide-Containing ARV Regimen Drug. Interaction¸in People Living with HIV: Case Series Report" @default.
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- W4387424240 doi "https://doi.org/10.1016/j.jiph.2023.10.011" @default.
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