FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387424618> ?p ?o ?g. }

• W4387424618 endingPage "101936" @default.
• W4387424618 startingPage "101936" @default.
• W4387424618 abstract "Liver transplantation (LT) is the best choice for patients with end-stage liver diseases. In order to better understand pathophysiological alterations in LT, we aimed to identify potential hub genes and inhibitory compounds involved in the LT process. Four pairs of peripheral blood mononuclear cell (PBMC) samples of the LT recipients before and after surgery were collected and taken for transcriptome sequencing. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed for the screened differentially expressed genes (DEGs) between pre- and post-operation groups. Common DEGs were obtained from GO and KEGG enriched pathways, followed by protein-protein interaction (PPI) network construction, hub gene identification, module analysis, and structure-based virtual screening process (SBVS). Compared to the pre-operation stage, 4745 genes were down-regulated and 798 up-regulated after LT. GO analysis showed that the DEGs were enriched in ribosome-related translation regulation, and KEGG analysis indicated that infection and immune-related pathways and diseases were largely enriched. A large number of down-regulated DEGs were not only associated with ribosome-related pathways but also with the alterations of epigenetic modifications, in particular ubiquitination. Moreover, through the PPI network of 29 common genes from GO and KEGG-enriched pathways, 7 hub genes were identified, including PTEN, MYC, EIF2S1, EIF4EBP1, HSP90AB1, TP53, and HSPA8, which were mainly involved in the PI3K-AKT signaling pathway. SBVS of the seed molecule PTEN (PDB code: 1D5R) predicted top hits compounds that may serve as potential inhibitors of PTEN, of which the compound ZINC4235331 had the lowest binding affinity of -10 kcal/mol. The significance of screened hub genes and potential inhibitors involved in the process of LT provides novel therapeutic strategies for improving the outcomes of LT recipients during surgery." @default.
• W4387424618 created "2023-10-08" @default.
• W4387424618 creator A5000388603 @default.
• W4387424618 creator A5012612049 @default.
• W4387424618 creator A5013410509 @default.
• W4387424618 creator A5022100956 @default.
• W4387424618 creator A5038903380 @default.
• W4387424618 creator A5041797648 @default.
• W4387424618 creator A5043006012 @default.
• W4387424618 creator A5050419964 @default.
• W4387424618 creator A5052349888 @default.
• W4387424618 creator A5053529699 @default.
• W4387424618 creator A5054199825 @default.
• W4387424618 creator A5055838753 @default.
• W4387424618 creator A5056258901 @default.
• W4387424618 date "2023-12-01" @default.
• W4387424618 modified "2023-10-11" @default.
• W4387424618 title "Identification of hub genes and potential inhibitory compounds in the process of liver transplantation through transcriptome sequencing" @default.
• W4387424618 cites W1665091962 @default.
• W4387424618 cites W1854617081 @default.
• W4387424618 cites W2023545773 @default.
• W4387424618 cites W2054727161 @default.
• W4387424618 cites W2068056970 @default.
• W4387424618 cites W2083770932 @default.
• W4387424618 cites W2096173332 @default.
• W4387424618 cites W2103017472 @default.
• W4387424618 cites W2104005232 @default.
• W4387424618 cites W2114104545 @default.
• W4387424618 cites W2130410032 @default.
• W4387424618 cites W2179438025 @default.
• W4387424618 cites W2181681557 @default.
• W4387424618 cites W2200444859 @default.
• W4387424618 cites W2375924265 @default.
• W4387424618 cites W2598569565 @default.
• W4387424618 cites W2598979376 @default.
• W4387424618 cites W2750520189 @default.
• W4387424618 cites W2780860952 @default.
• W4387424618 cites W2795174081 @default.
• W4387424618 cites W2802447511 @default.
• W4387424618 cites W2809759737 @default.
• W4387424618 cites W2914019546 @default.
• W4387424618 cites W2943176404 @default.
• W4387424618 cites W2950360205 @default.
• W4387424618 cites W2951912016 @default.
• W4387424618 cites W2953732988 @default.
• W4387424618 cites W2953976355 @default.
• W4387424618 cites W3094005756 @default.
• W4387424618 cites W3105461507 @default.
• W4387424618 cites W3126632176 @default.
• W4387424618 cites W3127850202 @default.
• W4387424618 cites W3133990331 @default.
• W4387424618 cites W3186287941 @default.
• W4387424618 cites W3197129141 @default.
• W4387424618 cites W3198862328 @default.
• W4387424618 cites W4229449379 @default.
• W4387424618 cites W4242626214 @default.
• W4387424618 cites W4294216483 @default.
• W4387424618 cites W4318595810 @default.
• W4387424618 cites W4384819627 @default.
• W4387424618 doi "https://doi.org/10.1016/j.mcp.2023.101936" @default.
• W4387424618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37802426" @default.
• W4387424618 hasPublicationYear "2023" @default.
• W4387424618 type Work @default.
• W4387424618 citedByCount "0" @default.
• W4387424618 crossrefType "journal-article" @default.
• W4387424618 hasAuthorship W4387424618A5000388603 @default.
• W4387424618 hasAuthorship W4387424618A5012612049 @default.
• W4387424618 hasAuthorship W4387424618A5013410509 @default.
• W4387424618 hasAuthorship W4387424618A5022100956 @default.
• W4387424618 hasAuthorship W4387424618A5038903380 @default.
• W4387424618 hasAuthorship W4387424618A5041797648 @default.
• W4387424618 hasAuthorship W4387424618A5043006012 @default.
• W4387424618 hasAuthorship W4387424618A5050419964 @default.
• W4387424618 hasAuthorship W4387424618A5052349888 @default.
• W4387424618 hasAuthorship W4387424618A5053529699 @default.
• W4387424618 hasAuthorship W4387424618A5054199825 @default.
• W4387424618 hasAuthorship W4387424618A5055838753 @default.
• W4387424618 hasAuthorship W4387424618A5056258901 @default.
• W4387424618 hasBestOaLocation W43874246181 @default.
• W4387424618 hasConcept C104317684 @default.
• W4387424618 hasConcept C104397665 @default.
• W4387424618 hasConcept C150194340 @default.
• W4387424618 hasConcept C152724338 @default.
• W4387424618 hasConcept C162317418 @default.
• W4387424618 hasConcept C2777609662 @default.
• W4387424618 hasConcept C54355233 @default.
• W4387424618 hasConcept C62478195 @default.
• W4387424618 hasConcept C70721500 @default.
• W4387424618 hasConcept C86554907 @default.
• W4387424618 hasConcept C86803240 @default.
• W4387424618 hasConceptScore W4387424618C104317684 @default.
• W4387424618 hasConceptScore W4387424618C104397665 @default.
• W4387424618 hasConceptScore W4387424618C150194340 @default.
• W4387424618 hasConceptScore W4387424618C152724338 @default.
• W4387424618 hasConceptScore W4387424618C162317418 @default.
• W4387424618 hasConceptScore W4387424618C2777609662 @default.
• W4387424618 hasConceptScore W4387424618C54355233 @default.
• W4387424618 hasConceptScore W4387424618C62478195 @default.

• next