FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387425010> ?p ?o ?g. }

• W4387425010 endingPage "19" @default.
• W4387425010 startingPage "1" @default.
• W4387425010 abstract "AbstractPurpose To study the systemic inflammatory mediator levels in non-proliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME) and explore the correlation between systemic inflammatory mediators and DME.Methods In this prospective study, we included 25 patients without diabetes (control group) and 75 patients with type 2 diabetes mellitus (diabetic group). According to fundus examination, the diabetic group patients were divided into: diabetic patients without diabetic retinopathy (DR) (Non-DR group), NPDR patients without DME (Non-DME group), and NPDR patients with DME (DME group). Serum levels of a broad panel of inflammatory mediators were analysed by multiplex protein quantitative detection technology based on a flow cytometry detection system.Results The interferon-γ (IFN-γ) levels were significantly higher in DME group and Non-DME group as compared to control group (p = 0.023 and p = 0.033) and Non-DR group (p = 0.009 and p = 0.015). Significantly higher values were obtained in DME group and Non-DME group as compared to control group for the interleukin-8 (IL-8) (p = 0.003 and p = 0.003). The IL-23 levels were significantly elevated in DME group and Non-DR group than in Non-DME group (p = 0.013 and p = 0.004). The diabetic group had significantly higher serum levels of IL-8 and IL-33 (p = 0.001 and p = 0.011), and lower serum levels of tumor necrosis factor-α (TNF-α) (p = 0.027) in comparison with control group.Conclusions The changed levels of serum inflammatory mediators suggest that the systemic inflammatory mediators are involved in the pathogenesis of NPDR patients with DME. Such effects can guide clinical monitoring, diagnostic and therapeutic approaches for DME patients at an early stage.Keywords: Diabetic macular edemanon-proliferative diabetic retinopathyinflammatory mediatorsinterferon-γinterleukinsDisclaimerAs a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also. Disclosure statementNo potential conflict of interest was reported by the authors.Data availability statementThe datasets generated and analyzed during the current study are not publicly available, but are available from the corresponding author upon reasonable request.Additional informationFundingThis work was supported by the “State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund” under Grant number SKL-HIDCA-2021-DX8." @default.
• W4387425010 created "2023-10-08" @default.
• W4387425010 creator A5001741546 @default.
• W4387425010 creator A5004406113 @default.
• W4387425010 creator A5093021524 @default.
• W4387425010 date "2023-10-07" @default.
• W4387425010 modified "2023-10-09" @default.
• W4387425010 title "Systemic Inflammatory Mediator Levels in Non-proliferative Diabetic Retinopathy Patients with Diabetic Macular Edema" @default.
• W4387425010 cites W1507217056 @default.
• W4387425010 cites W1986398399 @default.
• W4387425010 cites W1996571556 @default.
• W4387425010 cites W2009339330 @default.
• W4387425010 cites W2025870581 @default.
• W4387425010 cites W2110068074 @default.
• W4387425010 cites W2123634291 @default.
• W4387425010 cites W2138480916 @default.
• W4387425010 cites W2139589490 @default.
• W4387425010 cites W2157710399 @default.
• W4387425010 cites W2299551279 @default.
• W4387425010 cites W2391191430 @default.
• W4387425010 cites W2466029418 @default.
• W4387425010 cites W2489954735 @default.
• W4387425010 cites W2618952437 @default.
• W4387425010 cites W2749248168 @default.
• W4387425010 cites W2767261857 @default.
• W4387425010 cites W2767463793 @default.
• W4387425010 cites W2770252852 @default.
• W4387425010 cites W2789680212 @default.
• W4387425010 cites W2794774196 @default.
• W4387425010 cites W2806143306 @default.
• W4387425010 cites W2943978286 @default.
• W4387425010 cites W3036001076 @default.
• W4387425010 cites W3046548967 @default.
• W4387425010 cites W3091357565 @default.
• W4387425010 cites W3142188635 @default.
• W4387425010 cites W4211115914 @default.
• W4387425010 cites W4240531687 @default.
• W4387425010 cites W71110322 @default.
• W4387425010 doi "https://doi.org/10.1080/02713683.2023.2268306" @default.
• W4387425010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37804222" @default.
• W4387425010 hasPublicationYear "2023" @default.
• W4387425010 type Work @default.
• W4387425010 citedByCount "0" @default.
• W4387425010 crossrefType "journal-article" @default.
• W4387425010 hasAuthorship W4387425010A5001741546 @default.
• W4387425010 hasAuthorship W4387425010A5004406113 @default.
• W4387425010 hasAuthorship W4387425010A5093021524 @default.
• W4387425010 hasConcept C118487528 @default.
• W4387425010 hasConcept C126322002 @default.
• W4387425010 hasConcept C134018914 @default.
• W4387425010 hasConcept C164027704 @default.
• W4387425010 hasConcept C17991360 @default.
• W4387425010 hasConcept C2776391266 @default.
• W4387425010 hasConcept C2776914184 @default.
• W4387425010 hasConcept C2778313320 @default.
• W4387425010 hasConcept C2779829184 @default.
• W4387425010 hasConcept C2780886150 @default.
• W4387425010 hasConcept C555293320 @default.
• W4387425010 hasConcept C71924100 @default.
• W4387425010 hasConcept C90924648 @default.
• W4387425010 hasConceptScore W4387425010C118487528 @default.
• W4387425010 hasConceptScore W4387425010C126322002 @default.
• W4387425010 hasConceptScore W4387425010C134018914 @default.
• W4387425010 hasConceptScore W4387425010C164027704 @default.
• W4387425010 hasConceptScore W4387425010C17991360 @default.
• W4387425010 hasConceptScore W4387425010C2776391266 @default.
• W4387425010 hasConceptScore W4387425010C2776914184 @default.
• W4387425010 hasConceptScore W4387425010C2778313320 @default.
• W4387425010 hasConceptScore W4387425010C2779829184 @default.
• W4387425010 hasConceptScore W4387425010C2780886150 @default.
• W4387425010 hasConceptScore W4387425010C555293320 @default.
• W4387425010 hasConceptScore W4387425010C71924100 @default.
• W4387425010 hasConceptScore W4387425010C90924648 @default.
• W4387425010 hasLocation W43874250101 @default.
• W4387425010 hasLocation W43874250102 @default.
• W4387425010 hasOpenAccess W4387425010 @default.
• W4387425010 hasPrimaryLocation W43874250101 @default.
• W4387425010 hasRelatedWork W186124986 @default.
• W4387425010 hasRelatedWork W1979866946 @default.
• W4387425010 hasRelatedWork W1980571360 @default.
• W4387425010 hasRelatedWork W2429379476 @default.
• W4387425010 hasRelatedWork W2584074590 @default.
• W4387425010 hasRelatedWork W3167510834 @default.
• W4387425010 hasRelatedWork W3176448898 @default.
• W4387425010 hasRelatedWork W3207986206 @default.
• W4387425010 hasRelatedWork W4226141369 @default.
• W4387425010 hasRelatedWork W4379115808 @default.
• W4387425010 isParatext "false" @default.
• W4387425010 isRetracted "false" @default.
• W4387425010 workType "article" @default.