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- W4387425051 abstract "Pseudo-energies are a generic method to incorporate extrinsic information into energy-directed RNA secondary structure predictions. Consensus structures of RNA families, usually predicted from multiple sequence alignments, can be treated as soft constraints in this manner. In this contribution we first revisit the theoretical framework and then show that pseudo-energies for the centroid base pairs of the consensus structure result in a substantial increase in folding accuracy. In contrast, only a moderate improvement can be achieved if only the information that a base is predominantly paired is utilized." @default.
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- W4387425051 date "2023-01-01" @default.
- W4387425051 modified "2023-10-08" @default.
- W4387425051 title "Phylogenetic Information as Soft Constraints in RNA Secondary Structure Prediction" @default.
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- W4387425051 doi "https://doi.org/10.1007/978-981-99-7074-2_21" @default.
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