Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387425830> ?p ?o ?g. }
- W4387425830 abstract "BACKGROUND Mendelian randomization (MR) offers a powerful approach to study potential causal associations between exposures and health outcomes by using genetic variants associated with an exposure as instrumental variables. In this systematic review, we aimed to summarize previous MR studies and to evaluate the evidence for causality for a broad range of exposures in relation to coronary artery disease and stroke. METHODS AND RESULTS MR studies investigating the association of any genetically predicted exposure with coronary artery disease or stroke were identified. Studies were classified into 4 categories built on the significance of the main MR analysis results and its concordance with sensitivity analyses, namely, robust, probable, suggestive, and insufficient. Studies reporting associations that did not perform any sensitivity analysis were classified as nonevaluable. We identified 2725 associations eligible for evaluation, examining 535 distinct exposures. Of them, 141 were classified as robust, 353 as probable, 110 as suggestive, and 926 had insufficient evidence. The most robust associations were observed for anthropometric traits, lipids, and lipoproteins and type 2 diabetes with coronary artery; disease and clinical measurements with coronary artery disease and stroke; and thrombotic factors with stroke. CONCLUSIONS Despite the large number of studies that have been conducted, only a limited number of associations were supported by robust evidence. Approximately half of the studies reporting associations presented an MR sensitivity analysis along with the main analysis that further supported the causality of associations. Future research should focus on more thorough assessments of sensitivity MR analyses and further assessments of mediation effects or nonlinearity of associations." @default.
- W4387425830 created "2023-10-08" @default.
- W4387425830 creator A5009120205 @default.
- W4387425830 creator A5009177205 @default.
- W4387425830 creator A5020053314 @default.
- W4387425830 creator A5021540554 @default.
- W4387425830 creator A5029211219 @default.
- W4387425830 creator A5040666463 @default.
- W4387425830 creator A5051387435 @default.
- W4387425830 creator A5054061856 @default.
- W4387425830 creator A5057413062 @default.
- W4387425830 creator A5067212579 @default.
- W4387425830 creator A5070901233 @default.
- W4387425830 creator A5073435344 @default.
- W4387425830 creator A5076117969 @default.
- W4387425830 creator A5080125366 @default.
- W4387425830 creator A5087932701 @default.
- W4387425830 creator A5090663293 @default.
- W4387425830 creator A5090791122 @default.
- W4387425830 date "2023-10-07" @default.
- W4387425830 modified "2023-10-18" @default.
- W4387425830 title "Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies" @default.
- W4387425830 cites W1972696558 @default.
- W4387425830 cites W1990287548 @default.
- W4387425830 cites W2050761447 @default.
- W4387425830 cites W2068544781 @default.
- W4387425830 cites W2103855412 @default.
- W4387425830 cites W2112203259 @default.
- W4387425830 cites W2117697673 @default.
- W4387425830 cites W2117830880 @default.
- W4387425830 cites W2132279603 @default.
- W4387425830 cites W2135899868 @default.
- W4387425830 cites W2160654392 @default.
- W4387425830 cites W2161382132 @default.
- W4387425830 cites W2166218331 @default.
- W4387425830 cites W2228897323 @default.
- W4387425830 cites W2334457243 @default.
- W4387425830 cites W2410056395 @default.
- W4387425830 cites W2481252033 @default.
- W4387425830 cites W2497451827 @default.
- W4387425830 cites W2550031966 @default.
- W4387425830 cites W2554464977 @default.
- W4387425830 cites W2560744595 @default.
- W4387425830 cites W2565422852 @default.
- W4387425830 cites W2589064416 @default.
- W4387425830 cites W2626288726 @default.
- W4387425830 cites W2736634847 @default.
- W4387425830 cites W2740494915 @default.
- W4387425830 cites W2744806422 @default.
- W4387425830 cites W2748400555 @default.
- W4387425830 cites W2749237115 @default.
- W4387425830 cites W2763901719 @default.
- W4387425830 cites W2783618236 @default.
- W4387425830 cites W2793007799 @default.
- W4387425830 cites W2805488963 @default.
- W4387425830 cites W2808425510 @default.
- W4387425830 cites W2810682357 @default.
- W4387425830 cites W2829328274 @default.
- W4387425830 cites W2895972601 @default.
- W4387425830 cites W2898507529 @default.
- W4387425830 cites W2898571386 @default.
- W4387425830 cites W2900683357 @default.
- W4387425830 cites W2908650877 @default.
- W4387425830 cites W2909838828 @default.
- W4387425830 cites W2910587421 @default.
- W4387425830 cites W2915276679 @default.
- W4387425830 cites W2925038939 @default.
- W4387425830 cites W2928401928 @default.
- W4387425830 cites W2943766116 @default.
- W4387425830 cites W2944006800 @default.
- W4387425830 cites W2946081713 @default.
- W4387425830 cites W2949757596 @default.
- W4387425830 cites W2950172732 @default.
- W4387425830 cites W2951580019 @default.
- W4387425830 cites W2953169830 @default.
- W4387425830 cites W2967096050 @default.
- W4387425830 cites W2967336288 @default.
- W4387425830 cites W2967393462 @default.
- W4387425830 cites W2968382418 @default.
- W4387425830 cites W2968787706 @default.
- W4387425830 cites W2969832424 @default.
- W4387425830 cites W2974073520 @default.
- W4387425830 cites W2974125088 @default.
- W4387425830 cites W2975351875 @default.
- W4387425830 cites W2982223905 @default.
- W4387425830 cites W2991007563 @default.
- W4387425830 cites W2995300205 @default.
- W4387425830 cites W2996030562 @default.
- W4387425830 cites W3000763405 @default.
- W4387425830 cites W3002416957 @default.
- W4387425830 cites W3005124854 @default.
- W4387425830 cites W3006439045 @default.
- W4387425830 cites W3016619435 @default.
- W4387425830 cites W3022600773 @default.
- W4387425830 cites W3025010103 @default.
- W4387425830 cites W3026946252 @default.
- W4387425830 cites W3029930991 @default.
- W4387425830 cites W3030473434 @default.
- W4387425830 cites W3033249124 @default.
- W4387425830 cites W3034996976 @default.