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• W4387425888 endingPage "105045" @default.
• W4387425888 startingPage "105045" @default.
• W4387425888 abstract "Collective cell migration is essential for a wide range of biological processes such as: morphogenesis, wound healing, and cancer spreading. However, it is well known that migrating epithelial collectives frequently undergo jamming, stay trapped some period of time, and then start migration again. Consequently, only a part of epithelial cells actively contributes to the tissue development. In contrast to epithelial cells, migrating mesenchymal collectives successfully avoid the jamming. It has been confirmed that the epithelial unjamming cannot be treated as the epithelial-to-mesenchymal transition. Some other mechanism is responsible for the epithelial jamming/unjamming. Despite extensive research devoted to study the cell jamming/unjamming, we still do not understand the origin of this phenomenon. The origin is connected to physical factors such as: the cell compressive residual stress accumulation and surface characteristics of migrating (unjamming) and resting (jamming) epithelial clusters which depend primarily on the strength of cell-cell adhesion contacts and cell contractility. The main goal of this theoretical consideration is to clarify these cause-consequence relations." @default.
• W4387425888 created "2023-10-08" @default.
• W4387425888 creator A5061579402 @default.
• W4387425888 creator A5090136484 @default.
• W4387425888 date "2023-12-01" @default.
• W4387425888 modified "2023-10-13" @default.
• W4387425888 title "Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects" @default.
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• W4387425888 doi "https://doi.org/10.1016/j.biosystems.2023.105045" @default.
• W4387425888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37813238" @default.
• W4387425888 hasPublicationYear "2023" @default.
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