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- W4387426597 abstract "Herein we report an unprecedented and efficient methodology for accessing 6-alkoxy-Δ4,6-diene-3-one derivatives. Such scaffolds were serendipitously obtained in the course of the study of the reaction of Δ4-3-keto steroids with catalytic amounts of iodine in refluxing methanol. A series of 6-methoxy and 6-ethoxy- Δ4,6-diene-3-ones were prepared from easily-available sterols in a two-step sequence; first, oxidation of sterols furnished the Δ4-3-keto steroids, which were then refluxed with ethanol or methanol with I2 as catalyst to obtain a series of ten derivatives. Furthermore, this protocol was also effective for the introduction of a larger carbon chain at C-6. Druglikeliness properties of synthesized compounds were predicted using the SwissADME tool." @default.
- W4387426597 created "2023-10-08" @default.
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- W4387426597 date "2023-12-01" @default.
- W4387426597 modified "2023-10-15" @default.
- W4387426597 title "A novel and easy protocol to obtain 6-alkoxy-Δ4,6-diene-3-one derivatives from available sterols" @default.
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- W4387426597 doi "https://doi.org/10.1016/j.steroids.2023.109323" @default.
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