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- W4387432707 abstract "患者女，66岁，反复发热伴胸闷15 d入院。胸部CT检查：左肺上叶见一截面积大小11.4 cm×7.2 cm的软组织密度影，边界尚清，周围有分叶。随后患者行左肺上叶切除及肺门淋巴结清扫手术。镜下观察：肿瘤细胞呈上皮样，细胞核染色质粗颗粒状，缺乏明显的核仁，细胞质少，偏嗜酸性，细胞边界不清楚。肿瘤细胞呈实性片状排列或形成模糊的结节，可见细胞稀疏区域和密集区域混杂存在，稀疏区的肿瘤细胞可形成孤立的旋涡状结构，伴有富于黏液样和透明玻璃样变的间质。免疫组织化学染色结果：CD34、波形蛋白、INI1阳性，S-100蛋白部分阳性，间变性淋巴瘤激酶（ALK）弱阳性，Ki-67阳性指数30%。肿瘤融合基因RNA检测：ALK基因重排，与EML4融合，产生EML4-ALK融合基因。熟悉掌握ALK重排软组织肿瘤的临床病理学特征，对于软组织肿瘤精准分类以及对高度侵袭性肿瘤采取ALK抑制剂靶向治疗至关重要。." @default.
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- W4387432707 date "2023-10-08" @default.
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- W4387432707 title "[Pulmonary ALK-rearranged soft tissue tumor with EML4-ALK gene fusion: report of a case]." @default.
- W4387432707 doi "https://doi.org/10.3760/cma.j.cn112151-20230712-00454" @default.
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