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• W4387432731 abstract "Abstract Listeria monocytogenes is a foodborne bacterium that naturally occurs in the soil. Originating from there, it contaminates crops and infects farm animals and their consumption by humans may lead to listeriosis, a systemic life‐threatening infectious disease. The adaptation of L. monocytogenes to such contrastive habitats is reflected by the presence of virulence genes for host infection and other genes for survival under environmental conditions. Among the latter are ABC transporters for excretion of antibiotics produced by environmental competitors; however, most of these transporters have not been characterized. Here, we generated a collection of promoter‐ lacZ fusions for genes encoding ABC‐type drug transporters of L. monocytogenes and screened this reporter strain collection for induction using a library of natural compounds produced by various environmental microorganisms. We found that the timABR locus ( lmo1964‐lmo1962 ) was induced by the macrodiolide antibiotic tartrolon B, which is synthesized by the soil myxobacterium Sorangium cellulosum . Tartrolon B resistance of L. monocytogenes was dependent on timAB , encoding the ATPase and the permease component of a novel ABC transporter. Moreover, transplantation of timAB was sufficient to confer tartrolon B resistance to Bacillus subtilis . Expression of the timABR locus was found to be auto‐repressed by the TimR repressor, whose repressing activity was lost in the presence of tartrolon B. We also demonstrate that tartrolon sensitivity was suppressed by high external potassium concentrations, suggesting that tartrolon acts as potassium ionophore. Our results help to map the ecological interactions of an important human pathogen with its co‐residing species within their joint natural reservoir." @default.
• W4387432731 created "2023-10-09" @default.
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• W4387432731 date "2023-10-07" @default.
• W4387432731 modified "2023-10-09" @default.
• W4387432731 title "Tartrolon sensing and detoxification by the <i>Listeria monocytogenes timABR</i> resistance operon" @default.
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• W4387432731 doi "https://doi.org/10.1111/mmi.15178" @default.
• W4387432731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37804169" @default.
• W4387432731 hasPublicationYear "2023" @default.
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