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- W4387432827 abstract "Optically controlled neuromodulation is a promising approach for basic research of neural circuits and the clinical treatment of neurological diseases. However, developing a non-invasive and well-controllable system to deliver accurate and effective neural stimulation is challenging. Micro/nanorobots have shown great potential in various biomedical applications because of their precise controllability. Here, we present a magnetically manipulated optoelectronic hybrid microrobot (MOHR) for optically targeted non-genetic neuromodulation. By integrating the magnetic component into the metal-insulator-semiconductor (MIS) junction design, the MOHR had excellent magnetic controllability and optoelectronic properties. The MOHR displayed a variety of magnetic manipulation modes that enabled precise and efficient navigation in different biofluids. Furthermore, the MOHR could achieve precision neuromodulation at the single-cell level because of its accurate targeting ability. This neuromodulation was achieved by the MOHR's photoelectric response to visible light irradiation, which enhanced the excitability of the targeted cells. Finally, we showed that the well-controllable MOHRs effectively restored neuronal activity in neurons damaged by β-amyloid, a pathogenic agent of Alzheimer's disease. By coupling precise controllability with efficient optoelectronic properties, the hybrid microrobot system is a promising strategy for targeted on-demand optical neuromodulation. This article is protected by copyright. All rights reserved." @default.
- W4387432827 created "2023-10-09" @default.
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- W4387432827 date "2023-10-08" @default.
- W4387432827 modified "2023-10-10" @default.
- W4387432827 title "Magnetically Manipulated Optoelectronic Hybrid Microrobots for Optically Targeted Non‐Genetic Neuromodulation" @default.
- W4387432827 doi "https://doi.org/10.1002/adma.202305632" @default.
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