FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387432846> ?p ?o ?g. }

• W4387432846 abstract "Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of multiple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring adipocytes.Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 126,829 high-quality nuclei from physiological mammary glands across five developmental stages (d 90 of gestation, G90; d 0 after lactation, L0; d 20 after lactation, L20; 2 d post natural involution, PI2; 7 d post natural involution, PI7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation (G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation (L0 and L20), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL21-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural involution (PI2 and PI7), epithelial cell populations dedifferentiate into mesenchymal stem cells to maintain the lactation potential of mammary glands for the next lactation cycle.The molecular mechanisms of dedifferentiation, proliferation and redifferentiation of adipocytes and epithelial cells were revealed from late pregnancy to natural involution. This cell transcriptomic profile constitutes an essential reference for future studies in the development and remodeling of the mammary gland at different stages." @default.
• W4387432846 created "2023-10-09" @default.
• W4387432846 creator A5003229507 @default.
• W4387432846 creator A5005080101 @default.
• W4387432846 creator A5027351085 @default.
• W4387432846 creator A5033964446 @default.
• W4387432846 creator A5037586182 @default.
• W4387432846 creator A5040354610 @default.
• W4387432846 creator A5052023214 @default.
• W4387432846 creator A5059220440 @default.
• W4387432846 creator A5059487418 @default.
• W4387432846 creator A5060464053 @default.
• W4387432846 creator A5064537565 @default.
• W4387432846 creator A5073529494 @default.
• W4387432846 creator A5081165104 @default.
• W4387432846 creator A5085813632 @default.
• W4387432846 date "2023-10-08" @default.
• W4387432846 modified "2023-10-11" @default.
• W4387432846 title "A cell transcriptomic profile provides insights into adipocytes of porcine mammary gland across development" @default.
• W4387432846 cites W1820794045 @default.
• W4387432846 cites W1834589661 @default.
• W4387432846 cites W1852351310 @default.
• W4387432846 cites W1972055054 @default.
• W4387432846 cites W1972874435 @default.
• W4387432846 cites W1974184487 @default.
• W4387432846 cites W1978308081 @default.
• W4387432846 cites W1978421730 @default.
• W4387432846 cites W1979440527 @default.
• W4387432846 cites W1979598304 @default.
• W4387432846 cites W1980285125 @default.
• W4387432846 cites W1985196273 @default.
• W4387432846 cites W1989571181 @default.
• W4387432846 cites W2010867675 @default.
• W4387432846 cites W2013692456 @default.
• W4387432846 cites W2018850963 @default.
• W4387432846 cites W2026032229 @default.
• W4387432846 cites W2032259976 @default.
• W4387432846 cites W204171329 @default.
• W4387432846 cites W2053445819 @default.
• W4387432846 cites W2053682792 @default.
• W4387432846 cites W2060020051 @default.
• W4387432846 cites W2061013234 @default.
• W4387432846 cites W2062329509 @default.
• W4387432846 cites W2072585359 @default.
• W4387432846 cites W2081106130 @default.
• W4387432846 cites W2081206580 @default.
• W4387432846 cites W2085904846 @default.
• W4387432846 cites W2091774189 @default.
• W4387432846 cites W2093208620 @default.
• W4387432846 cites W2096007387 @default.
• W4387432846 cites W2097893773 @default.
• W4387432846 cites W2099635702 @default.
• W4387432846 cites W2103130163 @default.
• W4387432846 cites W2119309849 @default.
• W4387432846 cites W2159330083 @default.
• W4387432846 cites W2258999208 @default.
• W4387432846 cites W2291752147 @default.
• W4387432846 cites W2291767161 @default.
• W4387432846 cites W2464471998 @default.
• W4387432846 cites W2474485504 @default.
• W4387432846 cites W2486860820 @default.
• W4387432846 cites W2518276948 @default.
• W4387432846 cites W2531261367 @default.
• W4387432846 cites W2588275620 @default.
• W4387432846 cites W2735900593 @default.
• W4387432846 cites W2765704810 @default.
• W4387432846 cites W2769379242 @default.
• W4387432846 cites W2773586544 @default.
• W4387432846 cites W2774579621 @default.
• W4387432846 cites W2795466496 @default.
• W4387432846 cites W2800727099 @default.
• W4387432846 cites W2802954358 @default.
• W4387432846 cites W2807829586 @default.
• W4387432846 cites W2808086361 @default.
• W4387432846 cites W2810183894 @default.
• W4387432846 cites W2889326414 @default.
• W4387432846 cites W2889516443 @default.
• W4387432846 cites W2900386834 @default.
• W4387432846 cites W2901965014 @default.
• W4387432846 cites W2902050841 @default.
• W4387432846 cites W2908139053 @default.
• W4387432846 cites W2921265148 @default.
• W4387432846 cites W2937607815 @default.
• W4387432846 cites W2939132513 @default.
• W4387432846 cites W2944521546 @default.
• W4387432846 cites W2974150138 @default.
• W4387432846 cites W2986163958 @default.
• W4387432846 cites W2994532040 @default.
• W4387432846 cites W3004374734 @default.
• W4387432846 cites W3010817007 @default.
• W4387432846 cites W3022842142 @default.
• W4387432846 cites W3033230153 @default.
• W4387432846 cites W3035327867 @default.
• W4387432846 cites W3048888372 @default.
• W4387432846 cites W3080237557 @default.
• W4387432846 cites W3082397016 @default.
• W4387432846 cites W3093243546 @default.
• W4387432846 cites W3096536084 @default.
• W4387432846 cites W3103160523 @default.
• W4387432846 cites W3116649600 @default.

• next