Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387432936> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4387432936 endingPage "3614" @default.
- W4387432936 startingPage "3605" @default.
- W4387432936 abstract "Brasilicardin A (BraA) is a natural diterpene glycoside isolated from the pathogenic actinomycete Nocardia brasiliensis IFM 0406 with highly potent immunosuppressive activity (IC50=0.057 μg/mL). BraA potently inhibits the uptake of amino acids that are substrates for amino acid transport system L of T cells, which is different from the existing clinical immunosuppressants. BraA is more potent in a mouse mixed lymphocyte reaction and less toxic against various human cell lines compared with the known clinical immunosuppressants, such as cyclosporin A, ascomycin and tacrolimus. Therefore, BraA attracted more attention as a new promising immunosuppressant. However, the development of this promising immunosuppressant as drug for medical use is so far hindered because BraA has the unusual and synthetically challenging skeleton and shows the low-yield production in the natural pathogenic producer. This review introduces the molecular structure of BraA, its activity, mechanism of action, chemical synthesis of BraA analogs, heterologous expression of gene cluster, and an application of combining microbial and chemical synthesis for production of BraA, with the aim to facilitate the efficient production of BraA and its analogs." @default.
- W4387432936 created "2023-10-09" @default.
- W4387432936 creator A5003453021 @default.
- W4387432936 creator A5012520604 @default.
- W4387432936 creator A5013442845 @default.
- W4387432936 date "2023-09-25" @default.
- W4387432936 modified "2023-10-09" @default.
- W4387432936 title "[Advances of the novel immunosuppressant brasilicardin A]." @default.
- W4387432936 doi "https://doi.org/10.13345/j.cjb.221006" @default.
- W4387432936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37805841" @default.
- W4387432936 hasPublicationYear "2023" @default.
- W4387432936 type Work @default.
- W4387432936 citedByCount "0" @default.
- W4387432936 crossrefType "journal-article" @default.
- W4387432936 hasAuthorship W4387432936A5003453021 @default.
- W4387432936 hasAuthorship W4387432936A5012520604 @default.
- W4387432936 hasAuthorship W4387432936A5013442845 @default.
- W4387432936 hasConcept C104317684 @default.
- W4387432936 hasConcept C108305142 @default.
- W4387432936 hasConcept C185592680 @default.
- W4387432936 hasConcept C202751555 @default.
- W4387432936 hasConcept C2776120743 @default.
- W4387432936 hasConcept C2780115692 @default.
- W4387432936 hasConcept C36857842 @default.
- W4387432936 hasConcept C40767141 @default.
- W4387432936 hasConcept C515207424 @default.
- W4387432936 hasConcept C55493867 @default.
- W4387432936 hasConcept C70721500 @default.
- W4387432936 hasConcept C86803240 @default.
- W4387432936 hasConcept C98274493 @default.
- W4387432936 hasConceptScore W4387432936C104317684 @default.
- W4387432936 hasConceptScore W4387432936C108305142 @default.
- W4387432936 hasConceptScore W4387432936C185592680 @default.
- W4387432936 hasConceptScore W4387432936C202751555 @default.
- W4387432936 hasConceptScore W4387432936C2776120743 @default.
- W4387432936 hasConceptScore W4387432936C2780115692 @default.
- W4387432936 hasConceptScore W4387432936C36857842 @default.
- W4387432936 hasConceptScore W4387432936C40767141 @default.
- W4387432936 hasConceptScore W4387432936C515207424 @default.
- W4387432936 hasConceptScore W4387432936C55493867 @default.
- W4387432936 hasConceptScore W4387432936C70721500 @default.
- W4387432936 hasConceptScore W4387432936C86803240 @default.
- W4387432936 hasConceptScore W4387432936C98274493 @default.
- W4387432936 hasIssue "9" @default.
- W4387432936 hasLocation W43874329361 @default.
- W4387432936 hasOpenAccess W4387432936 @default.
- W4387432936 hasPrimaryLocation W43874329361 @default.
- W4387432936 hasRelatedWork W2041535313 @default.
- W4387432936 hasRelatedWork W2131381401 @default.
- W4387432936 hasRelatedWork W2358995494 @default.
- W4387432936 hasRelatedWork W2363368974 @default.
- W4387432936 hasRelatedWork W2383405945 @default.
- W4387432936 hasRelatedWork W2785455203 @default.
- W4387432936 hasRelatedWork W2902337863 @default.
- W4387432936 hasRelatedWork W2943629202 @default.
- W4387432936 hasRelatedWork W3127069326 @default.
- W4387432936 hasRelatedWork W4281482299 @default.
- W4387432936 hasVolume "39" @default.
- W4387432936 isParatext "false" @default.
- W4387432936 isRetracted "false" @default.
- W4387432936 workType "article" @default.