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- W4387433046 abstract "As central players in cellular structure and function, proteins have long been central themes in life science research. Analyzing the impact of protein sequence variation on its structure and function is one of the important means to study proteins. In recent years, a technology called deep mutational scanning (DMS) has been widely used in the field of protein research. It introduces thousands of mutations in parallel in specific regions of proteins through high-abundance DNA libraries. After screening, high-throughput sequencing is employed to score each mutation, revealing sequence-function correlations. Due to its high-throughput, fast and easy, and labor-saving features, DMS has become an important method for protein function research and protein engineering. This review briefly summarizes the principle of DMS technology, highlighting its applications in mammalian cells. Moreover, this review analyzes the current technical bottlenecks, aiming to facilitate relevant research." @default.
- W4387433046 created "2023-10-09" @default.
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- W4387433046 date "2023-09-25" @default.
- W4387433046 modified "2023-10-09" @default.
- W4387433046 title "[Application of deep mutational scanning technology in protein research]." @default.
- W4387433046 doi "https://doi.org/10.13345/j.cjb.221050" @default.
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