Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387433071> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4387433071 endingPage "3643" @default.
- W4387433071 startingPage "3628" @default.
- W4387433071 abstract "Small-molecule anticancer drugs inhibited tumor growth based on targeted inhibition of specific proteins, while most of oncogenic proteins are undruggable. Proteolysis targeting chimeras (PROTAC) is an attractive and general strategy for treating cancer based on targeted degradation of oncogenic proteins. This review briefly describes the peptide-based PTOTAC and small molecule-based PROTAC. Subsequently, we summarize the development of targeted delivery of PROTAC, such as targeting molecule-mediated targeted delivery of PROTAC, nanomaterial-mediated targeted delivery of PROTAC and controllable activation of small-molecular PROTAC prodrug. Such strategies show potential application in improving tumor selectivity, overcoming off-target effect and reducing biotoxicity. At the end, the druggability of PROTAC is prospected." @default.
- W4387433071 created "2023-10-09" @default.
- W4387433071 creator A5004243415 @default.
- W4387433071 creator A5004893652 @default.
- W4387433071 creator A5023542069 @default.
- W4387433071 creator A5030405098 @default.
- W4387433071 creator A5053531628 @default.
- W4387433071 date "2023-09-25" @default.
- W4387433071 modified "2023-10-14" @default.
- W4387433071 title "[Advances in targeted delivery of proteolysis targeting chimeras in cancer therapy]." @default.
- W4387433071 doi "https://doi.org/10.13345/j.cjb.230006" @default.
- W4387433071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37805843" @default.
- W4387433071 hasPublicationYear "2023" @default.
- W4387433071 type Work @default.
- W4387433071 citedByCount "0" @default.
- W4387433071 crossrefType "journal-article" @default.
- W4387433071 hasAuthorship W4387433071A5004243415 @default.
- W4387433071 hasAuthorship W4387433071A5004893652 @default.
- W4387433071 hasAuthorship W4387433071A5023542069 @default.
- W4387433071 hasAuthorship W4387433071A5030405098 @default.
- W4387433071 hasAuthorship W4387433071A5053531628 @default.
- W4387433071 hasConcept C104317684 @default.
- W4387433071 hasConcept C10679952 @default.
- W4387433071 hasConcept C108215921 @default.
- W4387433071 hasConcept C121608353 @default.
- W4387433071 hasConcept C126511603 @default.
- W4387433071 hasConcept C161624437 @default.
- W4387433071 hasConcept C178790620 @default.
- W4387433071 hasConcept C181199279 @default.
- W4387433071 hasConcept C185592680 @default.
- W4387433071 hasConcept C2779820397 @default.
- W4387433071 hasConcept C2781230642 @default.
- W4387433071 hasConcept C2781307694 @default.
- W4387433071 hasConcept C2983331546 @default.
- W4387433071 hasConcept C2992195973 @default.
- W4387433071 hasConcept C502942594 @default.
- W4387433071 hasConcept C54355233 @default.
- W4387433071 hasConcept C55493867 @default.
- W4387433071 hasConcept C70721500 @default.
- W4387433071 hasConcept C86803240 @default.
- W4387433071 hasConceptScore W4387433071C104317684 @default.
- W4387433071 hasConceptScore W4387433071C10679952 @default.
- W4387433071 hasConceptScore W4387433071C108215921 @default.
- W4387433071 hasConceptScore W4387433071C121608353 @default.
- W4387433071 hasConceptScore W4387433071C126511603 @default.
- W4387433071 hasConceptScore W4387433071C161624437 @default.
- W4387433071 hasConceptScore W4387433071C178790620 @default.
- W4387433071 hasConceptScore W4387433071C181199279 @default.
- W4387433071 hasConceptScore W4387433071C185592680 @default.
- W4387433071 hasConceptScore W4387433071C2779820397 @default.
- W4387433071 hasConceptScore W4387433071C2781230642 @default.
- W4387433071 hasConceptScore W4387433071C2781307694 @default.
- W4387433071 hasConceptScore W4387433071C2983331546 @default.
- W4387433071 hasConceptScore W4387433071C2992195973 @default.
- W4387433071 hasConceptScore W4387433071C502942594 @default.
- W4387433071 hasConceptScore W4387433071C54355233 @default.
- W4387433071 hasConceptScore W4387433071C55493867 @default.
- W4387433071 hasConceptScore W4387433071C70721500 @default.
- W4387433071 hasConceptScore W4387433071C86803240 @default.
- W4387433071 hasIssue "9" @default.
- W4387433071 hasLocation W43874330711 @default.
- W4387433071 hasOpenAccess W4387433071 @default.
- W4387433071 hasPrimaryLocation W43874330711 @default.
- W4387433071 hasRelatedWork W2000687555 @default.
- W4387433071 hasRelatedWork W2108269141 @default.
- W4387433071 hasRelatedWork W2158546283 @default.
- W4387433071 hasRelatedWork W2259552966 @default.
- W4387433071 hasRelatedWork W2546981861 @default.
- W4387433071 hasRelatedWork W2556855892 @default.
- W4387433071 hasRelatedWork W4214810602 @default.
- W4387433071 hasRelatedWork W4280541024 @default.
- W4387433071 hasRelatedWork W4318253519 @default.
- W4387433071 hasRelatedWork W4378515879 @default.
- W4387433071 hasVolume "39" @default.
- W4387433071 isParatext "false" @default.
- W4387433071 isRetracted "false" @default.
- W4387433071 workType "article" @default.