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- W4387434597 abstract "Background: Systemic isotretinoin is an effective treatment for acne, but the significant relapse rate requires a search for optimal daily doses to prolong disease remission.
 Purpose: To compare the results of systemic therapy of moderate-to-severe resistant and severe papulopustular pustular acne with isotretinoin at daily doses of 0.5; 0.7 and 1.0 mg/kg body weight.
 Methods: In a retrospective study, data from outpatient records and facial skin corneometry results of 125 individuals (95 acne patients, 30 healthy individuals) were analyzed. Patients with acne received isotretinoin (Sotret)at a daily dose of0.5; 0.7 or 1.0 mg/kg body weight, with a cumulative dose of 120 mg/kg body weight in all patients. The duration of follow-up of patients, according to outpatient records, was 18 months.
 Results: Isotretinoin systemic therapy was effective in patients in all compared groups. The resolution of inflammatory elements was faster (p0.001) in those who received doses of isotretinoin 0.7 and 1.0 mg/kg body weight. After treatment, elevated values of sebumetry, skin relief, pore size, and pigmentation were normalized in all groups. There was a significant difference in the incidence of adverse events depending on the dose of isotretinoin. The number of patients with relapses registered at 18-week follow-up after therapy in Group I was 6 (18.75%); in Group II, 4 (12.5%); in Group III, 1 (3.2%), the differences between the groups being significant (p=0.003).
 Conclusion: Therapy of moderate-to-severe resistant and severe papulopustular acne with systemic isotretinoin (Sotret) at daily doses of 0.5; 0.7 and 1.0 mg/kg at a cumulative dose of 120 mg/kg body weight demonstrates comparable clinical efficacy. However, recurrence rates during the 18-month follow-up period correlated with the daily dose of the drug." @default.
- W4387434597 created "2023-10-09" @default.
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- W4387434597 date "2023-10-16" @default.
- W4387434597 modified "2023-10-18" @default.
- W4387434597 title "RETROSPECTIVE ANALYSIS OF THE RESULTS OF SYSTEMIC THERAPY OF MODERATE TO SEVERE PAPULO-PUSTULAR ACNE" @default.
- W4387434597 cites W1978050245 @default.
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- W4387434597 doi "https://doi.org/10.25208/vdv5711" @default.
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