FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387435880> ?p ?o ?g. }

• W4387435880 endingPage "4282" @default.
• W4387435880 startingPage "4282" @default.
• W4387435880 abstract "Intestinal peristalsis is vital for gastrointestinal physiology and host homeostasis and is frequently dysregulated in intestinal disorders. Gut microbiota can regulate gut motility, especially through the tryptophan metabolism pathway. However, the role of indoles as microbial tryptophan metabolites in colonic function requires further exploration. Here, we show that the delivery of indole acetic acid (IAA) targeting the colon can improve gut motility by activating the aryl hydrocarbon receptor (AHR). To achieve colon-targeted delivery, Eudragit S-100 (ES) and chitosan (CS) were used as drug carriers. After optimisation, IAA-loaded ES-coated CS nanoparticles exhibited an encapsulation efficiency of 83% and a drug-loading capacity of 16%. These nanoparticles exhibited pH-dependent characteristics and remained stable in acidic conditions and the upper intestine. In simulated intestinal fluid (pH 7.4) and colonic lumen, considerable amounts of IAA were released after approximately 4 h. Compared with free IAA, the nanoparticles exerted enhanced therapeutic effects on gut movement disorders induced by loperamide. The efficacy of IAA treatment was attributable to the activation of the AHR signalling pathway and increased levels of AHR agonists. Furthermore, the oral administration of IAA-loaded nanoparticles promoted serotonin secretion and maintained the intestinal barrier function. The experimental outcomes demonstrate the efficiency of the proposed colon-specific delivery system and highlight the role of IAA, produced by gut microbiota metabolism, in regulating gut peristalsis through AHR activation." @default.
• W4387435880 created "2023-10-09" @default.
• W4387435880 creator A5017541508 @default.
• W4387435880 creator A5019707913 @default.
• W4387435880 creator A5030921116 @default.
• W4387435880 creator A5036352366 @default.
• W4387435880 creator A5040558103 @default.
• W4387435880 creator A5075902396 @default.
• W4387435880 creator A5084803944 @default.
• W4387435880 creator A5087935200 @default.
• W4387435880 date "2023-10-08" @default.
• W4387435880 modified "2023-10-18" @default.
• W4387435880 title "Colon-Targeted Delivery of Indole Acetic Acid Helps Regulate Gut Motility by Activating the AHR Signaling Pathway" @default.
• W4387435880 cites W1422715083 @default.
• W4387435880 cites W1999973175 @default.
• W4387435880 cites W2068103849 @default.
• W4387435880 cites W2075763186 @default.
• W4387435880 cites W2077494205 @default.
• W4387435880 cites W2575984858 @default.
• W4387435880 cites W2588467249 @default.
• W4387435880 cites W2597688930 @default.
• W4387435880 cites W2615801135 @default.
• W4387435880 cites W2765916778 @default.
• W4387435880 cites W2802744456 @default.
• W4387435880 cites W2807728333 @default.
• W4387435880 cites W2886401819 @default.
• W4387435880 cites W2972269795 @default.
• W4387435880 cites W2978981344 @default.
• W4387435880 cites W3004904380 @default.
• W4387435880 cites W3011521750 @default.
• W4387435880 cites W3049896770 @default.
• W4387435880 cites W3089112777 @default.
• W4387435880 cites W3093392946 @default.
• W4387435880 cites W3132253566 @default.
• W4387435880 cites W3133779799 @default.
• W4387435880 cites W3137177918 @default.
• W4387435880 cites W3155616884 @default.
• W4387435880 cites W3189995589 @default.
• W4387435880 cites W4205663465 @default.
• W4387435880 cites W4221078420 @default.
• W4387435880 cites W4224255261 @default.
• W4387435880 cites W4286111299 @default.
• W4387435880 cites W4296117667 @default.
• W4387435880 cites W4310035855 @default.
• W4387435880 cites W4317708653 @default.
• W4387435880 cites W575774518 @default.
• W4387435880 doi "https://doi.org/10.3390/nu15194282" @default.
• W4387435880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37836566" @default.
• W4387435880 hasPublicationYear "2023" @default.
• W4387435880 type Work @default.
• W4387435880 citedByCount "0" @default.
• W4387435880 crossrefType "journal-article" @default.
• W4387435880 hasAuthorship W4387435880A5017541508 @default.
• W4387435880 hasAuthorship W4387435880A5019707913 @default.
• W4387435880 hasAuthorship W4387435880A5030921116 @default.
• W4387435880 hasAuthorship W4387435880A5036352366 @default.
• W4387435880 hasAuthorship W4387435880A5040558103 @default.
• W4387435880 hasAuthorship W4387435880A5075902396 @default.
• W4387435880 hasAuthorship W4387435880A5084803944 @default.
• W4387435880 hasAuthorship W4387435880A5087935200 @default.
• W4387435880 hasBestOaLocation W43874358801 @default.
• W4387435880 hasConcept C104317684 @default.
• W4387435880 hasConcept C185592680 @default.
• W4387435880 hasConcept C2776706248 @default.
• W4387435880 hasConcept C2777882243 @default.
• W4387435880 hasConcept C33594762 @default.
• W4387435880 hasConcept C515207424 @default.
• W4387435880 hasConcept C51911345 @default.
• W4387435880 hasConcept C539455810 @default.
• W4387435880 hasConcept C55493867 @default.
• W4387435880 hasConcept C58207958 @default.
• W4387435880 hasConcept C86339819 @default.
• W4387435880 hasConcept C86803240 @default.
• W4387435880 hasConcept C95444343 @default.
• W4387435880 hasConcept C98274493 @default.
• W4387435880 hasConceptScore W4387435880C104317684 @default.
• W4387435880 hasConceptScore W4387435880C185592680 @default.
• W4387435880 hasConceptScore W4387435880C2776706248 @default.
• W4387435880 hasConceptScore W4387435880C2777882243 @default.
• W4387435880 hasConceptScore W4387435880C33594762 @default.
• W4387435880 hasConceptScore W4387435880C515207424 @default.
• W4387435880 hasConceptScore W4387435880C51911345 @default.
• W4387435880 hasConceptScore W4387435880C539455810 @default.
• W4387435880 hasConceptScore W4387435880C55493867 @default.
• W4387435880 hasConceptScore W4387435880C58207958 @default.
• W4387435880 hasConceptScore W4387435880C86339819 @default.
• W4387435880 hasConceptScore W4387435880C86803240 @default.
• W4387435880 hasConceptScore W4387435880C95444343 @default.
• W4387435880 hasConceptScore W4387435880C98274493 @default.
• W4387435880 hasFunder F4320322769 @default.
• W4387435880 hasIssue "19" @default.
• W4387435880 hasLocation W43874358801 @default.
• W4387435880 hasLocation W43874358802 @default.
• W4387435880 hasOpenAccess W4387435880 @default.
• W4387435880 hasPrimaryLocation W43874358801 @default.
• W4387435880 hasRelatedWork W1974048771 @default.
• W4387435880 hasRelatedWork W2000477360 @default.
• W4387435880 hasRelatedWork W2067245114 @default.

• next