Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387439509> ?p ?o ?g. }
- W4387439509 endingPage "11" @default.
- W4387439509 startingPage "1" @default.
- W4387439509 abstract "2,4-Dibromophenol (DBP) has several industrial applications, including as a wood preservative and flame retardant. This study investigated the interaction between DBP and human hemoglobin (Hb) using spectroscopic, molecular docking and molecular dynamic techniques. The UV-visible spectra showed ground-state complex formation between DBP and Hb. Fluorescence studies revealed that DBP binding caused significant quenching of Hb fluorescence by the static quenching mechanism. The binding of DBP to Hb is a spontaneous process that involves van der Waals forces and hydrogen bonds. There is one DBP binding site on each Hb molecule that is located at the α1β2 interface of Hb. DBP binding did not alter the microenvironment of tyrosine and tryptophan residues in Hb. Circular dichroism studies revealed that DBP increased the α-helical content of Hb. The intrinsic esterase activity of Hb was inhibited by DBP in a concentration-dependent manner. Molecular docking showed that DBP binds to Hb via hydrogen bonds, hydrophobic, van der Waals and π-π interactions. Molecular dynamics simulation confirmed that the Hb-DBP complex is stable. Overall, the results of this study clearly show that DBP induces structural changes and interferes with the function of Hb. This can have important implications for human health.Communicated by Ramaswamy H. Sarma." @default.
- W4387439509 created "2023-10-10" @default.
- W4387439509 creator A5023338166 @default.
- W4387439509 creator A5026066843 @default.
- W4387439509 creator A5058640631 @default.
- W4387439509 creator A5087084165 @default.
- W4387439509 creator A5089060060 @default.
- W4387439509 date "2023-10-09" @default.
- W4387439509 modified "2023-10-10" @default.
- W4387439509 title "Studies on the interaction of 2,4-dibromophenol with human hemoglobin using multi-spectroscopic, molecular docking and molecular dynamics techniques" @default.
- W4387439509 cites W2006092770 @default.
- W4387439509 cites W2013680702 @default.
- W4387439509 cites W2014865718 @default.
- W4387439509 cites W2015006282 @default.
- W4387439509 cites W2016466957 @default.
- W4387439509 cites W2030346302 @default.
- W4387439509 cites W2031426081 @default.
- W4387439509 cites W2040184556 @default.
- W4387439509 cites W2044172327 @default.
- W4387439509 cites W2045650312 @default.
- W4387439509 cites W2055792934 @default.
- W4387439509 cites W2063722041 @default.
- W4387439509 cites W2071055678 @default.
- W4387439509 cites W2075705506 @default.
- W4387439509 cites W2101298518 @default.
- W4387439509 cites W2104571730 @default.
- W4387439509 cites W2134880599 @default.
- W4387439509 cites W2134967712 @default.
- W4387439509 cites W2152033472 @default.
- W4387439509 cites W2584966375 @default.
- W4387439509 cites W2624733358 @default.
- W4387439509 cites W2753556633 @default.
- W4387439509 cites W2893659216 @default.
- W4387439509 cites W2898938484 @default.
- W4387439509 cites W2911048107 @default.
- W4387439509 cites W2914884883 @default.
- W4387439509 cites W2933731187 @default.
- W4387439509 cites W2953517790 @default.
- W4387439509 cites W3006275595 @default.
- W4387439509 cites W3010758855 @default.
- W4387439509 cites W3026951492 @default.
- W4387439509 cites W3113239629 @default.
- W4387439509 cites W3128253086 @default.
- W4387439509 cites W3135280144 @default.
- W4387439509 cites W3164284655 @default.
- W4387439509 cites W3186891665 @default.
- W4387439509 cites W3196524745 @default.
- W4387439509 cites W3203520027 @default.
- W4387439509 cites W4200535345 @default.
- W4387439509 cites W4210630544 @default.
- W4387439509 cites W4210962630 @default.
- W4387439509 cites W4213321250 @default.
- W4387439509 cites W4226074812 @default.
- W4387439509 cites W4226172097 @default.
- W4387439509 cites W4282927041 @default.
- W4387439509 cites W4282959404 @default.
- W4387439509 cites W4287219238 @default.
- W4387439509 cites W4290803896 @default.
- W4387439509 cites W4295863567 @default.
- W4387439509 cites W4296114150 @default.
- W4387439509 cites W4296771020 @default.
- W4387439509 cites W4304005599 @default.
- W4387439509 cites W4353055837 @default.
- W4387439509 doi "https://doi.org/10.1080/07391102.2023.2264975" @default.
- W4387439509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37811549" @default.
- W4387439509 hasPublicationYear "2023" @default.
- W4387439509 type Work @default.
- W4387439509 citedByCount "0" @default.
- W4387439509 crossrefType "journal-article" @default.
- W4387439509 hasAuthorship W4387439509A5023338166 @default.
- W4387439509 hasAuthorship W4387439509A5026066843 @default.
- W4387439509 hasAuthorship W4387439509A5058640631 @default.
- W4387439509 hasAuthorship W4387439509A5087084165 @default.
- W4387439509 hasAuthorship W4387439509A5089060060 @default.
- W4387439509 hasConcept C112887158 @default.
- W4387439509 hasConcept C121332964 @default.
- W4387439509 hasConcept C121745418 @default.
- W4387439509 hasConcept C126061179 @default.
- W4387439509 hasConcept C133571119 @default.
- W4387439509 hasConcept C147597530 @default.
- W4387439509 hasConcept C159110408 @default.
- W4387439509 hasConcept C178790620 @default.
- W4387439509 hasConcept C185592680 @default.
- W4387439509 hasConcept C2778917026 @default.
- W4387439509 hasConcept C32909587 @default.
- W4387439509 hasConcept C41685203 @default.
- W4387439509 hasConcept C55493867 @default.
- W4387439509 hasConcept C59593255 @default.
- W4387439509 hasConcept C62520636 @default.
- W4387439509 hasConcept C71240020 @default.
- W4387439509 hasConcept C71924100 @default.
- W4387439509 hasConcept C8010536 @default.
- W4387439509 hasConcept C90260826 @default.
- W4387439509 hasConcept C91881484 @default.
- W4387439509 hasConceptScore W4387439509C112887158 @default.
- W4387439509 hasConceptScore W4387439509C121332964 @default.
- W4387439509 hasConceptScore W4387439509C121745418 @default.
- W4387439509 hasConceptScore W4387439509C126061179 @default.