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• W4387439565 abstract "AbstractPlant yields are compromised due to abiotic and biotic stresses. A crucial biotic stress instigated by insect attack, is a major concern that limits crop production. To overcome the deleterious effect of herbivory, pesticides are used but long-term usage of pesticides can be harmful to the environment and human health. Understanding the plants’ inherent defense mechanism by interpreting the interaction pattern of defense-related proteins and signalling components and manipulating them to strengthen defense status, is one of the alternative approaches of green biotechnology. During insect attack, host plants initiate innumerable signalling pathways to activate defense response; Mitogen Activated Protein Kinase (MAPK) Pathway is a crucial component of signalling pathway that regulate the expression of downstream defense-related genes. MAPK pathway has three components: MAPKKK, MAPKK and MAPK. Earlier studies have shown participation of SIPK and WIPK (MAPKs) as well as MEK2 (MAPKK) during insect infestation and its association with plant defense. However, information on the third component and elucidation of the complete MAPK pathway are still elusive. Therefore, this study aims to identify the unknown component and decipher MAPK pathway in Nicotiana attenuata involved in plant defense against herbivory by identifying herbivory-inducible MAPKKKs and and their interaction with known partners of the MAPK pathway by docking and MD simulation. The possible pathway was predicted to be MAPKKK Na12134/Na04522-MEK2-SIPK/WIPK. Further, validation of the above interaction by in vitro and in vivo methods is highly recommended.Communicated by Ramaswamy H. SarmaKeywords: MAPK pathwayManduca sextaNicotiana attenuataherbivoryplant defense signalling AcknowledgementsAS acknowledge EMBO (European Molecular Biology Organization), Meyerhofstrasse Heidelberg, Germany, for providing EMBO fellowship.Author’s contributionAS conceived the idea and supervised the study. KNY, SRRG and MT performed the experiments and executed the bioinformatics analysis and KNY wrote the original draft. AS and IKS contributed to writing, reviewing, editing, and visualization. All the authors have read and agreed to the published version of the manuscript.Disclosure statementThe authors declare no conflict of interest.Additional informationFundingFinancial support was provided to AS by the Science and Engineering Research Board (SERB), Department of Science and Technology, New Delhi, India (SPG/2021/002969)." @default.
• W4387439565 created "2023-10-10" @default.
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• W4387439565 date "2023-10-09" @default.
• W4387439565 modified "2023-10-15" @default.
• W4387439565 title "Deciphering mitogen activated protein kinase pathway activated during insect attack in <i>Nicotiana attenuata</i>" @default.
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• W4387439565 doi "https://doi.org/10.1080/07391102.2023.2263795" @default.
• W4387439565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37811559" @default.
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