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- W4387440060 abstract "Efficient computation of optimal transport distance between distributions is of growing importance in data science. Sinkhorn-based methods are currently the state-of-the-art for such computations, but require $O(n^2)$ computations. In addition, Sinkhorn-based methods commonly use an Euclidean ground distance between datapoints. However, with the prevalence of manifold structured scientific data, it is often desirable to consider geodesic ground distance. Here, we tackle both issues by proposing Geodesic Sinkhorn -- based on diffusing a heat kernel on a manifold graph. Notably, Geodesic Sinkhorn requires only $O(nlog n)$ computation, as we approximate the heat kernel with Chebyshev polynomials based on the sparse graph Laplacian. We apply our method to the computation of barycenters of several distributions of high dimensional single cell data from patient samples undergoing chemotherapy. In particular, we define the barycentric distance as the distance between two such barycenters. Using this definition, we identify an optimal transport distance and path associated with the effect of treatment on cellular data." @default.
- W4387440060 created "2023-10-10" @default.
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- W4387440060 date "2023-09-26" @default.
- W4387440060 modified "2023-10-18" @default.
- W4387440060 title "Geodesic Sinkhorn for Fast and Accurate Optimal Transport on Manifolds." @default.
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- W4387440060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37808090" @default.
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