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- W4387440090 abstract "Abstract Hematopoietic stem cells are key players in hematopoiesis as the body maintains a physiologic steady state, and the signaling pathways and control mechanisms of these dynamic cells are implicated in processes from inflammation to cancer. Although the bone marrow is commonly regarded as the site of hematopoiesis and hematopoietic stem cell residence, these cells also circulate in the blood and reside in extramedullary tissues, including the lungs. Flow cytometry is an invaluable tool in evaluating hematopoietic stem cells, revealing their phenotypes and relative abundances in both healthy and diseased states. This review outlines current protocols and cell markers used in flow cytometric analysis of hematopoietic stem and progenitor cell populations. Specific niches within the bone marrow are discussed, as are metabolic processes that contribute to stem cell self‐renewal and differentiation, as well as the role of hematopoietic stem cells outside of the bone marrow at physiologic steady state. Finally, pulmonary extramedullary hematopoiesis and its associated disease states are outlined. Hematopoiesis in the lungs is a new and emerging concept, and discovering ways in which the study of lung‐resident hematopoietic stem cells can be translated from murine models to patients will impact clinical treatment." @default.
- W4387440090 created "2023-10-10" @default.
- W4387440090 creator A5013293260 @default.
- W4387440090 creator A5049485732 @default.
- W4387440090 creator A5091013719 @default.
- W4387440090 creator A5091110007 @default.
- W4387440090 date "2023-10-09" @default.
- W4387440090 modified "2023-10-12" @default.
- W4387440090 title "Hematopoietic stem cells and extramedullary hematopoiesis in the lungs" @default.
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