Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387440537> ?p ?o ?g. }
- W4387440537 abstract "Additive manufacturing, commonly known as 3D printing, allows decentralized drug fabrication of orally administered tablets. Microneedles are comparatively favorable for self-administered transdermal drug delivery with improved absorption and bioavailability. Due to the cross-scale geometric characteristics, 3D-printed microneedles face a significant trade-off between the feature resolution and production speed in conventional layer-wise deposition sequences. In this study, we introduce an economical and scalable direct ink drawing strategy to create drug-loaded microneedles. A freestanding microneedle is efficiently generated upon each pneumatic extrusion and controlled drawing process. Sharp tips of ∼5 μm are formed with submillimeter nozzles, representing 2 orders of magnitude improved resolution. As the key enabler of this fabrication strategy, the yield-stress fluid inks are formulated by simply filling silica nanoparticles into regular polymer solutions. The approach is compatible with various microneedles based on dissolvable, biodegradable, and nondegradable polymers. Various matrices are readily adopted to adjust the release behaviors of the drug-loaded microneedles. Successful fabrication of multifunctional patches with heterogeneously integrated microneedles allows the treatment of melanoma via synergistic photothermal therapy and combination chemotherapy. The personalized patches are designed for cancer severity to achieve high therapeutic efficacy with minimal side effects. The direct ink drawing reported here provides a facile and low-cost fabrication strategy for multifunctional microneedle patches for self-administering transdermal drug delivery." @default.
- W4387440537 created "2023-10-10" @default.
- W4387440537 creator A5002241866 @default.
- W4387440537 creator A5029647972 @default.
- W4387440537 creator A5035441171 @default.
- W4387440537 creator A5041250238 @default.
- W4387440537 creator A5041338277 @default.
- W4387440537 creator A5041486760 @default.
- W4387440537 creator A5046657661 @default.
- W4387440537 creator A5051384319 @default.
- W4387440537 creator A5055158964 @default.
- W4387440537 creator A5065777163 @default.
- W4387440537 creator A5068706606 @default.
- W4387440537 creator A5089076377 @default.
- W4387440537 creator A5089521834 @default.
- W4387440537 date "2023-10-08" @default.
- W4387440537 modified "2023-10-15" @default.
- W4387440537 title "Multifunctional Microneedle Patches via Direct Ink Drawing of Nanocomposite Inks for Personalized Transdermal Drug Delivery" @default.
- W4387440537 cites W1070748348 @default.
- W4387440537 cites W1541250240 @default.
- W4387440537 cites W1897953391 @default.
- W4387440537 cites W1968770683 @default.
- W4387440537 cites W1980142291 @default.
- W4387440537 cites W1987593270 @default.
- W4387440537 cites W1987753882 @default.
- W4387440537 cites W1990424776 @default.
- W4387440537 cites W1992838973 @default.
- W4387440537 cites W2005943078 @default.
- W4387440537 cites W2007539416 @default.
- W4387440537 cites W2014975258 @default.
- W4387440537 cites W2034751554 @default.
- W4387440537 cites W2042669918 @default.
- W4387440537 cites W2054294261 @default.
- W4387440537 cites W2075001207 @default.
- W4387440537 cites W2077241706 @default.
- W4387440537 cites W2080047588 @default.
- W4387440537 cites W2080430067 @default.
- W4387440537 cites W2089143024 @default.
- W4387440537 cites W2091049304 @default.
- W4387440537 cites W2095569714 @default.
- W4387440537 cites W2125628414 @default.
- W4387440537 cites W2127687724 @default.
- W4387440537 cites W2148104232 @default.
- W4387440537 cites W2148676114 @default.
- W4387440537 cites W2300453277 @default.
- W4387440537 cites W2305946569 @default.
- W4387440537 cites W2406843092 @default.
- W4387440537 cites W2421275313 @default.
- W4387440537 cites W2588644411 @default.
- W4387440537 cites W2620492608 @default.
- W4387440537 cites W2622003939 @default.
- W4387440537 cites W2791443927 @default.
- W4387440537 cites W2900824955 @default.
- W4387440537 cites W2900905586 @default.
- W4387440537 cites W2907493741 @default.
- W4387440537 cites W2916533817 @default.
- W4387440537 cites W2917386416 @default.
- W4387440537 cites W2969758768 @default.
- W4387440537 cites W2971734191 @default.
- W4387440537 cites W2988972782 @default.
- W4387440537 cites W3009063690 @default.
- W4387440537 cites W3011648518 @default.
- W4387440537 cites W3039603402 @default.
- W4387440537 cites W3039977092 @default.
- W4387440537 cites W3044858173 @default.
- W4387440537 cites W3114657416 @default.
- W4387440537 cites W3132782516 @default.
- W4387440537 cites W3157631129 @default.
- W4387440537 cites W3160176851 @default.
- W4387440537 cites W3161396539 @default.
- W4387440537 cites W3165239041 @default.
- W4387440537 cites W3165720345 @default.
- W4387440537 cites W3198447155 @default.
- W4387440537 cites W3211670717 @default.
- W4387440537 cites W4200446840 @default.
- W4387440537 cites W4210313592 @default.
- W4387440537 cites W4220795894 @default.
- W4387440537 cites W4221011642 @default.
- W4387440537 cites W4225845169 @default.
- W4387440537 cites W4251776867 @default.
- W4387440537 cites W4281901178 @default.
- W4387440537 cites W4285592750 @default.
- W4387440537 cites W4311441586 @default.
- W4387440537 doi "https://doi.org/10.1021/acsnano.3c04758" @default.
- W4387440537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37805947" @default.
- W4387440537 hasPublicationYear "2023" @default.
- W4387440537 type Work @default.
- W4387440537 citedByCount "0" @default.
- W4387440537 crossrefType "journal-article" @default.
- W4387440537 hasAuthorship W4387440537A5002241866 @default.
- W4387440537 hasAuthorship W4387440537A5029647972 @default.
- W4387440537 hasAuthorship W4387440537A5035441171 @default.
- W4387440537 hasAuthorship W4387440537A5041250238 @default.
- W4387440537 hasAuthorship W4387440537A5041338277 @default.
- W4387440537 hasAuthorship W4387440537A5041486760 @default.
- W4387440537 hasAuthorship W4387440537A5046657661 @default.
- W4387440537 hasAuthorship W4387440537A5051384319 @default.
- W4387440537 hasAuthorship W4387440537A5055158964 @default.
- W4387440537 hasAuthorship W4387440537A5065777163 @default.
- W4387440537 hasAuthorship W4387440537A5068706606 @default.