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• W4387440810 abstract "Background: Radiation burden from CT examinations increases rapidly with the increased clinical use frequency. Previous studies have disclosed the association between radiation exposure and the increased double-strand breaks (DSBs) and change in DNA methylation. However, whether the induced DSBs by CT examination recover within 24h and whether an CT examination induces detectable gene-specific methylation changes are still unclear. The aim of the present study was to analyze γ-H2AX in the peripheral blood lymphocyte (PBL) of healthy adults before and after CT examination and to discover the differentially methylated positions (DMPs) along with an analysis of DNA methylation changes caused by CT examination.Materials and Methods: Peripheral blood samples 4ml were drawn from 20 healthy volunteers at 3 time points: before CT examination, after CT examination 1h and after CT examination 24h. γ-H2AX immunofluorescence and Illumina Infinium Human MethylationEPIC BeadChip (850k BeadChip) was used respectively for the test of DSBs and the Epigenome-wide DNA methylation analysis. Linear mixed-effect (LME) models were used to evaluate the impacts of doses represented by different parameters and foci on genome-wide DNA methylation.Results: The number of γ-H2AX foci per cell at 1h showed linear dose-responses for the radiation doses represented by CT index volume (CTDIvol), dose length product (DLP), and blood absorbed dose, respectively. Residual γ-H2AX foci was observed after CT examination at 24h (p < 0.001). DMPs and γ-H2AX foci changes could be found within 1h. One CpG site related to PAX5 were significant changed by using most of parameters in LME models and didn't recover till 24h.Conclusions: Residual γ-H2AX foci exist after CT examination at 24h. The DNA methylation changes induced by CT examination may not recover within 24h. The DNA methylation had been changed as early as at 1h. The PAX5-related CpG site may be a potential biomarker of low-dose radiation.Clinical Relevance: The biological effects and the cancer risks of CT examination are still unclear. The present study is an effort to documenting the CT scan-induced events in 24h in-vivo. The CT scanning area should be strictly limited, and non-essential repeated operations shouldn't be performed within 24h.Trail registration: This study has been registered at Chinese Clinical Trail Registry (ChiCTR2200063358,05/09/2022)." @default.
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• W4387440810 date "2023-10-09" @default.
• W4387440810 modified "2023-10-10" @default.
• W4387440810 title "Low-dose radiation from CT examination induces DNA double-strand breaks and detectable changes of DNA methylation in peripheral blood cells" @default.
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• W4387440810 doi "https://doi.org/10.1080/09553002.2023.2267667" @default.
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