FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387440811> ?p ?o ?g. }

• W4387440811 abstract "Saccharomyces cerevisiae has emerged as a preferred source for industrial production of ribonucleic acids (RNAs) and their derivatives, which find wide applications in the food and pharmaceutical sectors. In this study, we employed a modified RNA polymerase I-mediated green fluorescent protein expression system, previously developed by our team, to screen and identify an industrial S. cerevisiae strain with an impressive 18.2% increase in the RNA content. Transcriptome analysis revealed heightened activity of genes and pathways associated with rRNA transcription, purine metabolism, and phosphate transport in the high nucleic acid content mutant strains. Our findings highlighted the crucial role of the transcription factor Sfp1p in enhancing the expression of two key components of the transcription initiation factor complex, Rrn7p and Rrn11p, thereby promoting rRNA synthesis. Moreover, elevated expression of 5'-inosine monophosphate dehydrogenases, regardless of the specific isoform (IMD2, 3, or 4), resulted in increased rRNA synthesis through heightened GTP levels. Additionally, exogenous phosphate application, coupled with overexpression of the phosphate transporter PHO84, led to a 61.4% boost in the RNA yield, reaching 2050.4 mg/L. This comprehensive study provides valuable insights into the mechanism of RNA synthesis and serves as a reference for augmenting RNA production in the food industry." @default.
• W4387440811 created "2023-10-10" @default.
• W4387440811 creator A5001719139 @default.
• W4387440811 creator A5013765598 @default.
• W4387440811 creator A5015968569 @default.
• W4387440811 creator A5017952613 @default.
• W4387440811 creator A5022076862 @default.
• W4387440811 creator A5045204358 @default.
• W4387440811 creator A5077588879 @default.
• W4387440811 creator A5077789495 @default.
• W4387440811 creator A5078391351 @default.
• W4387440811 creator A5087365202 @default.
• W4387440811 date "2023-10-09" @default.
• W4387440811 modified "2023-10-15" @default.
• W4387440811 title "Promoting Nucleic Acid Synthesis in <i>Saccharomyces cerevisiae</i> through Enhanced Expression of Rrn7p, Rrn11p, IMPDH, and Pho84p" @default.
• W4387440811 cites W1488701566 @default.
• W4387440811 cites W1523891609 @default.
• W4387440811 cites W1599982456 @default.
• W4387440811 cites W1618622512 @default.
• W4387440811 cites W1850569493 @default.
• W4387440811 cites W1966311581 @default.
• W4387440811 cites W1972378257 @default.
• W4387440811 cites W1978876381 @default.
• W4387440811 cites W1998675395 @default.
• W4387440811 cites W2001343867 @default.
• W4387440811 cites W2002527501 @default.
• W4387440811 cites W2004791437 @default.
• W4387440811 cites W2006371168 @default.
• W4387440811 cites W2010340351 @default.
• W4387440811 cites W2020474748 @default.
• W4387440811 cites W2026162105 @default.
• W4387440811 cites W2026740559 @default.
• W4387440811 cites W2031213311 @default.
• W4387440811 cites W2042417337 @default.
• W4387440811 cites W2053217422 @default.
• W4387440811 cites W2069927370 @default.
• W4387440811 cites W2082275139 @default.
• W4387440811 cites W2090849724 @default.
• W4387440811 cites W2107277218 @default.
• W4387440811 cites W2123380574 @default.
• W4387440811 cites W2124651203 @default.
• W4387440811 cites W2134485635 @default.
• W4387440811 cites W2146689147 @default.
• W4387440811 cites W2407047189 @default.
• W4387440811 cites W2519830843 @default.
• W4387440811 cites W2737693232 @default.
• W4387440811 cites W2804159563 @default.
• W4387440811 cites W2940251929 @default.
• W4387440811 cites W2978955949 @default.
• W4387440811 cites W3044098970 @default.
• W4387440811 cites W3080130022 @default.
• W4387440811 cites W3128559604 @default.
• W4387440811 cites W3157211542 @default.
• W4387440811 cites W3162079026 @default.
• W4387440811 cites W3179760805 @default.
• W4387440811 cites W4236155394 @default.
• W4387440811 cites W4313488208 @default.
• W4387440811 cites W4366238936 @default.
• W4387440811 cites W4366351709 @default.
• W4387440811 cites W854033594 @default.
• W4387440811 doi "https://doi.org/10.1021/acs.jafc.3c05035" @default.
• W4387440811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37811818" @default.
• W4387440811 hasPublicationYear "2023" @default.
• W4387440811 type Work @default.
• W4387440811 citedByCount "0" @default.
• W4387440811 crossrefType "journal-article" @default.
• W4387440811 hasAuthorship W4387440811A5001719139 @default.
• W4387440811 hasAuthorship W4387440811A5013765598 @default.
• W4387440811 hasAuthorship W4387440811A5015968569 @default.
• W4387440811 hasAuthorship W4387440811A5017952613 @default.
• W4387440811 hasAuthorship W4387440811A5022076862 @default.
• W4387440811 hasAuthorship W4387440811A5045204358 @default.
• W4387440811 hasAuthorship W4387440811A5077588879 @default.
• W4387440811 hasAuthorship W4387440811A5077789495 @default.
• W4387440811 hasAuthorship W4387440811A5078391351 @default.
• W4387440811 hasAuthorship W4387440811A5087365202 @default.
• W4387440811 hasConcept C104317684 @default.
• W4387440811 hasConcept C138885662 @default.
• W4387440811 hasConcept C150194340 @default.
• W4387440811 hasConcept C179926584 @default.
• W4387440811 hasConcept C24107716 @default.
• W4387440811 hasConcept C2777576037 @default.
• W4387440811 hasConcept C41895202 @default.
• W4387440811 hasConcept C55493867 @default.
• W4387440811 hasConcept C67705224 @default.
• W4387440811 hasConcept C67905577 @default.
• W4387440811 hasConcept C86803240 @default.
• W4387440811 hasConceptScore W4387440811C104317684 @default.
• W4387440811 hasConceptScore W4387440811C138885662 @default.
• W4387440811 hasConceptScore W4387440811C150194340 @default.
• W4387440811 hasConceptScore W4387440811C179926584 @default.
• W4387440811 hasConceptScore W4387440811C24107716 @default.
• W4387440811 hasConceptScore W4387440811C2777576037 @default.
• W4387440811 hasConceptScore W4387440811C41895202 @default.
• W4387440811 hasConceptScore W4387440811C55493867 @default.
• W4387440811 hasConceptScore W4387440811C67705224 @default.
• W4387440811 hasConceptScore W4387440811C67905577 @default.
• W4387440811 hasConceptScore W4387440811C86803240 @default.
• W4387440811 hasFunder F4320321001 @default.
• W4387440811 hasFunder F4320324174 @default.

• next