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• W4387441009 abstract "ABSTRACTBackground: Systemic lupus erythematosus (SLE) is an autoimmune disease that influences numerous body systems. Furin, tristetraprolin (TTP), and NOD, LRR, and pyrin domain-containing protein 3 (NLRP3) contribute in developing autoimmune illnesses.Aim: Understandthe role of furin, TTP, and NLRP3 mRNA gene expression in SLE pathogenesis and prognosis. Methods: Total 210 individuals were enrolled, divided in two group: cases and control; 105 participants in each group. Real-time quantitative PCR for furin, TTP,and NLRP3 mRNA gene expression were determined for each subject.Results: SLE patients showed significantly higher serum furin [median 20.10 (0.0–162.88) in comparison with control group [median 1.10 (0.33–8.64)] with significant pvalue (p < 0.001), for NLRP3 expression [median 7.03 (0.0–282.97) compared to control group [median 1.0 (0.44–9.48)] with significant p value (p = 0.006)but lower TTP [median 2.37 (0.0–30.13)] in comparison with control group [median 7.90 (1.0–29.29)] with significant p value (p < 0.001) . Elevated levels of Furin and NLRP3 and low levels of TTP were linked to increased illness activity.Conclusion: Furin and NLRP increase in SLE and higher with illness activity. TTP is lowerin SLE and negatively correlates with disease activity.KEYWORDS: Gene expressionNLRP3TTPfurinSLE Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementData are available when needed.Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article." @default.
• W4387441009 created "2023-10-10" @default.
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• W4387441009 date "2023-10-09" @default.
• W4387441009 modified "2023-10-14" @default.
• W4387441009 title "Identification of potential biomarkers for SLE through mRNA expression profiling" @default.
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• W4387441009 doi "https://doi.org/10.1080/15321819.2023.2266013" @default.
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