Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387441036> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4387441036 abstract "Direct thrombin inhibitors (DTIs) are usually monitored with the activated partial thromboplastin time (aPTT) or activated clotting time (ACT). Both are complex assays with multiple enzymatic steps, and performance may be influenced by physiologic and pathologic factors unrelated to the DTI. Simpler systems, such as clot-based dilute thrombin time (dTT) and chromogenic anti-factor IIa assays, have been developed for monitoring DTIs, but there is limited data on their performance in clinical settings.Medical records of patients who received bivalirudin between March 2020 and April 2022 at a single institution were reviewed for demographic data and adverse outcomes. Plasma samples drawn for aPTT testing were analyzed with chromogenic anti-IIa and dTT bivalirudin assays. Results were compared to bivalirudin dosing.Results of aPTT assays from 32 patients were compared with the chromogenic (n = 136) and dTT (n = 120) bivalirudin assays. Correlations between the aPTT and the chromogenic and dTT assays were poor (Spearman coefficients 0.55 and 0.62, respectively). There was a stronger correlation when results of the chromogenic and dTT assays were compared to each other (Spearman coefficient 0.92). When assay results were compared to bivalirudin dose, there were stronger correlations with the chromogenic and dTT assays than with the aPTT (Spearman coefficients 0.51, 0.63 and 0.22, respectively).There was considerable variation between results of specific bivalirudin assays and the aPTT. While bivalirudin assay results correlated better with administered drug dose, suggesting improving reliability, more studies are needed to determine if there is correlation between testing and clinical outcomes." @default.
- W4387441036 created "2023-10-10" @default.
- W4387441036 creator A5021496734 @default.
- W4387441036 creator A5033216285 @default.
- W4387441036 creator A5056651290 @default.
- W4387441036 creator A5063509147 @default.
- W4387441036 date "2023-10-09" @default.
- W4387441036 modified "2023-10-10" @default.
- W4387441036 title "Chromogenic and Clot-Based Bivalirudin Assays for Monitoring Anticoagulation" @default.
- W4387441036 cites W1988001010 @default.
- W4387441036 cites W2009226269 @default.
- W4387441036 cites W2049562629 @default.
- W4387441036 cites W2086400340 @default.
- W4387441036 cites W2090080882 @default.
- W4387441036 cites W2138679315 @default.
- W4387441036 cites W2164196526 @default.
- W4387441036 cites W2288532809 @default.
- W4387441036 cites W2320522282 @default.
- W4387441036 cites W2471145122 @default.
- W4387441036 cites W2571344505 @default.
- W4387441036 cites W2592699038 @default.
- W4387441036 cites W2733614998 @default.
- W4387441036 cites W2761866100 @default.
- W4387441036 cites W2806886886 @default.
- W4387441036 cites W2901204907 @default.
- W4387441036 cites W2936424090 @default.
- W4387441036 cites W3099161989 @default.
- W4387441036 cites W3198429226 @default.
- W4387441036 cites W4224017022 @default.
- W4387441036 doi "https://doi.org/10.1093/jalm/jfad072" @default.
- W4387441036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37811688" @default.
- W4387441036 hasPublicationYear "2023" @default.
- W4387441036 type Work @default.
- W4387441036 citedByCount "0" @default.
- W4387441036 crossrefType "journal-article" @default.
- W4387441036 hasAuthorship W4387441036A5021496734 @default.
- W4387441036 hasAuthorship W4387441036A5033216285 @default.
- W4387441036 hasAuthorship W4387441036A5056651290 @default.
- W4387441036 hasAuthorship W4387441036A5063509147 @default.
- W4387441036 hasConcept C126322002 @default.
- W4387441036 hasConcept C128463046 @default.
- W4387441036 hasConcept C185592680 @default.
- W4387441036 hasConcept C2776301958 @default.
- W4387441036 hasConcept C2776710957 @default.
- W4387441036 hasConcept C2777288759 @default.
- W4387441036 hasConcept C2777292125 @default.
- W4387441036 hasConcept C2777557582 @default.
- W4387441036 hasConcept C2777565915 @default.
- W4387441036 hasConcept C2778261982 @default.
- W4387441036 hasConcept C2778382381 @default.
- W4387441036 hasConcept C2778810321 @default.
- W4387441036 hasConcept C2779161974 @default.
- W4387441036 hasConcept C2780400711 @default.
- W4387441036 hasConcept C43617362 @default.
- W4387441036 hasConcept C500558357 @default.
- W4387441036 hasConcept C57002609 @default.
- W4387441036 hasConcept C71924100 @default.
- W4387441036 hasConcept C89560881 @default.
- W4387441036 hasConcept C98274493 @default.
- W4387441036 hasConceptScore W4387441036C126322002 @default.
- W4387441036 hasConceptScore W4387441036C128463046 @default.
- W4387441036 hasConceptScore W4387441036C185592680 @default.
- W4387441036 hasConceptScore W4387441036C2776301958 @default.
- W4387441036 hasConceptScore W4387441036C2776710957 @default.
- W4387441036 hasConceptScore W4387441036C2777288759 @default.
- W4387441036 hasConceptScore W4387441036C2777292125 @default.
- W4387441036 hasConceptScore W4387441036C2777557582 @default.
- W4387441036 hasConceptScore W4387441036C2777565915 @default.
- W4387441036 hasConceptScore W4387441036C2778261982 @default.
- W4387441036 hasConceptScore W4387441036C2778382381 @default.
- W4387441036 hasConceptScore W4387441036C2778810321 @default.
- W4387441036 hasConceptScore W4387441036C2779161974 @default.
- W4387441036 hasConceptScore W4387441036C2780400711 @default.
- W4387441036 hasConceptScore W4387441036C43617362 @default.
- W4387441036 hasConceptScore W4387441036C500558357 @default.
- W4387441036 hasConceptScore W4387441036C57002609 @default.
- W4387441036 hasConceptScore W4387441036C71924100 @default.
- W4387441036 hasConceptScore W4387441036C89560881 @default.
- W4387441036 hasConceptScore W4387441036C98274493 @default.
- W4387441036 hasLocation W43874410361 @default.
- W4387441036 hasLocation W43874410362 @default.
- W4387441036 hasOpenAccess W4387441036 @default.
- W4387441036 hasPrimaryLocation W43874410361 @default.
- W4387441036 hasRelatedWork W1503293547 @default.
- W4387441036 hasRelatedWork W1980134289 @default.
- W4387441036 hasRelatedWork W2012761317 @default.
- W4387441036 hasRelatedWork W2033481411 @default.
- W4387441036 hasRelatedWork W2076474436 @default.
- W4387441036 hasRelatedWork W2077129149 @default.
- W4387441036 hasRelatedWork W2151315762 @default.
- W4387441036 hasRelatedWork W2159134093 @default.
- W4387441036 hasRelatedWork W2384946928 @default.
- W4387441036 hasRelatedWork W2433245170 @default.
- W4387441036 isParatext "false" @default.
- W4387441036 isRetracted "false" @default.
- W4387441036 workType "article" @default.