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- W4387445876 abstract "A 69-year-old female presented with epigastric discomfort for 2 months and was admitted to the hospital because of pancreatic mass detected by Computed tomography (CT). The mass was significantly enhanced in the arterial phase and gradually decreased in the portal phase (Fig. 1A). CA199 and CEA are normal. Epstein-Barr virus, human immunodeficiency virus and human herpesvirus-8 are negative. Endoscopic ultrasound (EUS) revealed an oval hypoechoic mass in the pancreatic neck with clear boundary, internal calcified spots and abundant blood flow (Fig. 1B and supplementary video). EUS guided fine needle biopsy (EUS-FNB) with a 22G needle was performed. FNB pathology suggested multifocal sheets of lymphoid tissue with vascular endothelial hyperplasia and no pancreatic tissue component (Fig. 1C). The patient underwent a surgery. The morphological features and immunohistochemical profile of surgical pathology were consistent with Castleman disease (hyaline vascular type), which is characterized by the uniform distribution of follicles of similar size within the hyperplastic lymph nodes, forming a characteristic “onion skin”-like structure, and the entry of vitreous vessels (Fig. 1D). Pancreatic CD belongs to unicentric CD and is very rarer [ [1] Carbone A Borok M Damania B Gloghini A Polizzotto MN Jayanthan RK Fajgenbaum DC Bower M. Castleman disease. Nat Rev Dis Primers. 2021; 7: 84 Crossref PubMed Scopus (33) Google Scholar ]. Routine imaging is not diagnostic. EUS-FNB helps exclude pancreatic cancer and neuroendocrine tumors and is suggestive for CD diagnosis. The patient recovered well and is now being followed up." @default.
- W4387445876 created "2023-10-10" @default.
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- W4387445876 date "2023-10-01" @default.
- W4387445876 modified "2023-10-11" @default.
- W4387445876 title "EUS guided fine needle biopsy in the diagnosis of pancreatic Castleman disease (with video)" @default.
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- W4387445876 doi "https://doi.org/10.1016/j.dld.2023.09.022" @default.
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