FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387445948> ?p ?o ?g. }

• W4387445948 abstract "Abstract Background Psychiatric disorders (PD) refer to disorders that affect individual thinking, emotional regulation, and behavior. Notably, PD are associated with factors such as genes, proteins, and telomere-associated methylation. Method This study used GWAS, single-cell expression quantitative trait loci (sc-eQTL), and brain tissue eQTL and mQTL data of eleven psychiatric diseases for summary data-based Mendelian randomization analysis (SMR). A pQTL with a two-sample Mendelian randomization study was also used to investigate the mechanisms of telomere-related gene expression regulation and the causal relationship between telomere-related proteins and PD. Result Multiple telomere-related risk genes that are associated with PD were identified using SMR analysis. These genes were mainly expressed in cell types such as oligodendrocytes, excitatory neurons, dopaminergic neurons, and OPCs. Furthermore, several methylation-gene-disease regulatory signals were screened. Using a Mendelian randomization analysis, associations between seven telomere length-associated proteins i.e., GUSB, PSG5, MDM4, SPDEF, TNS2, MSP, and PLK1 and four PD i.e., bipolar disorder, major depressive disorder, neuroticism, and schizophrenia were identified. Conclusion The collective findings in this study suggest an association between PD and telomere-related genes. Further, it was observed that specific genes are expressed in specific cell types in the brain tissue and play an important role in the pathogenesis of PD. In addition, there is a causal relationship between telomere length and PD, and methylation may play a role in the relationship between telomere stability and PD. Taken together, telomere-related genes and proteins have important roles in the onset and development of PD. These findings provide a new understanding of the pathological mechanisms of PD and offer potential novel targets for their diagnosis and treatment. Future studies will help in further elucidating the relationship between telomeres and PD and potential therapeutic strategies in this regard." @default.
• W4387445948 created "2023-10-10" @default.
• W4387445948 creator A5020654618 @default.
• W4387445948 creator A5087378677 @default.
• W4387445948 date "2023-10-09" @default.
• W4387445948 modified "2023-10-11" @default.
• W4387445948 title "Mechanisms of action of telomere-related genes and telomere length-related proteins in relation to psychiatric disorders: A multi-method Mendelian Randomization study" @default.
• W4387445948 cites W1552502347 @default.
• W4387445948 cites W1733523167 @default.
• W4387445948 cites W1976555450 @default.
• W4387445948 cites W1990174682 @default.
• W4387445948 cites W2030132370 @default.
• W4387445948 cites W2104549677 @default.
• W4387445948 cites W2109959108 @default.
• W4387445948 cites W2116611710 @default.
• W4387445948 cites W2152656267 @default.
• W4387445948 cites W2164156722 @default.
• W4387445948 cites W2181445041 @default.
• W4387445948 cites W2219957567 @default.
• W4387445948 cites W2236290736 @default.
• W4387445948 cites W2328393125 @default.
• W4387445948 cites W2623056867 @default.
• W4387445948 cites W2625991279 @default.
• W4387445948 cites W2789305195 @default.
• W4387445948 cites W2905516213 @default.
• W4387445948 cites W2908002252 @default.
• W4387445948 cites W2911487850 @default.
• W4387445948 cites W2944545583 @default.
• W4387445948 cites W2949785910 @default.
• W4387445948 cites W2950375827 @default.
• W4387445948 cites W2952760964 @default.
• W4387445948 cites W2979994192 @default.
• W4387445948 cites W2983423072 @default.
• W4387445948 cites W3004565626 @default.
• W4387445948 cites W3083496521 @default.
• W4387445948 cites W3107527779 @default.
• W4387445948 cites W3134873297 @default.
• W4387445948 cites W3181408683 @default.
• W4387445948 cites W3190356341 @default.
• W4387445948 cites W3201088521 @default.
• W4387445948 cites W3215894083 @default.
• W4387445948 cites W4223520055 @default.
• W4387445948 cites W4289261763 @default.
• W4387445948 cites W4293068541 @default.
• W4387445948 cites W4308469685 @default.
• W4387445948 cites W4318071643 @default.
• W4387445948 cites W4323665349 @default.
• W4387445948 cites W4376225277 @default.
• W4387445948 doi "https://doi.org/10.21203/rs.3.rs-3402538/v1" @default.
• W4387445948 hasPublicationYear "2023" @default.
• W4387445948 type Work @default.
• W4387445948 citedByCount "0" @default.
• W4387445948 crossrefType "posted-content" @default.
• W4387445948 hasAuthorship W4387445948A5020654618 @default.
• W4387445948 hasAuthorship W4387445948A5087378677 @default.
• W4387445948 hasBestOaLocation W43874459481 @default.
• W4387445948 hasConcept C104317684 @default.
• W4387445948 hasConcept C106208931 @default.
• W4387445948 hasConcept C135763542 @default.
• W4387445948 hasConcept C150194340 @default.
• W4387445948 hasConcept C153209595 @default.
• W4387445948 hasConcept C168393362 @default.
• W4387445948 hasConcept C177336024 @default.
• W4387445948 hasConcept C190727270 @default.
• W4387445948 hasConcept C2779901538 @default.
• W4387445948 hasConcept C2993967602 @default.
• W4387445948 hasConcept C33288867 @default.
• W4387445948 hasConcept C54355233 @default.
• W4387445948 hasConcept C86803240 @default.
• W4387445948 hasConceptScore W4387445948C104317684 @default.
• W4387445948 hasConceptScore W4387445948C106208931 @default.
• W4387445948 hasConceptScore W4387445948C135763542 @default.
• W4387445948 hasConceptScore W4387445948C150194340 @default.
• W4387445948 hasConceptScore W4387445948C153209595 @default.
• W4387445948 hasConceptScore W4387445948C168393362 @default.
• W4387445948 hasConceptScore W4387445948C177336024 @default.
• W4387445948 hasConceptScore W4387445948C190727270 @default.
• W4387445948 hasConceptScore W4387445948C2779901538 @default.
• W4387445948 hasConceptScore W4387445948C2993967602 @default.
• W4387445948 hasConceptScore W4387445948C33288867 @default.
• W4387445948 hasConceptScore W4387445948C54355233 @default.
• W4387445948 hasConceptScore W4387445948C86803240 @default.
• W4387445948 hasLocation W43874459481 @default.
• W4387445948 hasOpenAccess W4387445948 @default.
• W4387445948 hasPrimaryLocation W43874459481 @default.
• W4387445948 hasRelatedWork W104925310 @default.
• W4387445948 hasRelatedWork W1995613491 @default.
• W4387445948 hasRelatedWork W2112543488 @default.
• W4387445948 hasRelatedWork W2143143063 @default.
• W4387445948 hasRelatedWork W2150283886 @default.
• W4387445948 hasRelatedWork W2464196154 @default.
• W4387445948 hasRelatedWork W2951751247 @default.
• W4387445948 hasRelatedWork W3098850595 @default.
• W4387445948 hasRelatedWork W4323567910 @default.
• W4387445948 hasRelatedWork W4384126845 @default.
• W4387445948 isParatext "false" @default.
• W4387445948 isRetracted "false" @default.
• W4387445948 workType "article" @default.