FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387446611> ?p ?o ?g. }

• W4387446611 abstract "Abstract Depression is considered the most prevalent neuropsychiatric disorder, which is also a multifactorial and complex disease. Oxidative stress and inflammation are essential contributors to the occurrence and progression of depression. On the other hand, methane is a new therapeutic gas that has been effective in increasing tissue resistance against ischemic injuries and inflammation, so this study was conducted to investigate the effect of methane-rich saline (MRS) on depression. The chronic unpredictable mild stress (CUMS) model was designed with daily mild stressors for two months. MRS was used to treat depressed rats. Depression-like behaviors were assessed with sucrose preference, open field, and forced swimming tests. Besides, the cognitive performance of the animals was determined by the Morris water maze. Serum corticosterone levels, the activity of antioxidant enzymes, and hippocampal malondialdehyde (MDA) levels were measured, and histological changes in the hippocampus were also investigated. The results indicated that MRS decreased depressive-like behaviors and cognitive impairment in depressed animals by increasing the ratio of sucrose consumption, elevating exploratory behaviors in the open field test, reducing immobility in the forced swimming test, and improving memory and learning in the Morris water maze. Additionally, the administration of MRS regulated the corticosterone level in the serum. The level of hippocampal lipid peroxidation and tissue damage was also reduced in treated animals. The results of the present study show that MRS reduces tissue damage and lipid peroxidation in the hippocampus of CUMS animals, which is followed by a significant improvement in behavioral and cognitive functions. Probably, MRS affects by reducing oxidative stress and improving the hypothalamus-pituitary-adrenal axis function." @default.
• W4387446611 created "2023-10-10" @default.
• W4387446611 creator A5004608798 @default.
• W4387446611 creator A5026577550 @default.
• W4387446611 creator A5081215156 @default.
• W4387446611 creator A5087918689 @default.
• W4387446611 date "2023-10-09" @default.
• W4387446611 modified "2023-10-11" @default.
• W4387446611 title "Methane-Rich Saline Ameliorates Depressive-Like Behaviors During Chronic Unpredictable Mild Stress (CUMS)" @default.
• W4387446611 cites W1609931466 @default.
• W4387446611 cites W1879552006 @default.
• W4387446611 cites W1977886842 @default.
• W4387446611 cites W2000676177 @default.
• W4387446611 cites W2054947287 @default.
• W4387446611 cites W2056539898 @default.
• W4387446611 cites W2083851081 @default.
• W4387446611 cites W2122982102 @default.
• W4387446611 cites W2148535867 @default.
• W4387446611 cites W2176819894 @default.
• W4387446611 cites W2229282577 @default.
• W4387446611 cites W2291578893 @default.
• W4387446611 cites W2405462462 @default.
• W4387446611 cites W2472252592 @default.
• W4387446611 cites W2514919387 @default.
• W4387446611 cites W2518256883 @default.
• W4387446611 cites W2522954781 @default.
• W4387446611 cites W2531530053 @default.
• W4387446611 cites W2565801438 @default.
• W4387446611 cites W2726644560 @default.
• W4387446611 cites W2767882478 @default.
• W4387446611 cites W2791057580 @default.
• W4387446611 cites W2793244616 @default.
• W4387446611 cites W2794230369 @default.
• W4387446611 cites W2807115904 @default.
• W4387446611 cites W2904597631 @default.
• W4387446611 cites W2993490190 @default.
• W4387446611 cites W3007255635 @default.
• W4387446611 cites W3023781031 @default.
• W4387446611 cites W3093480532 @default.
• W4387446611 cites W3111152729 @default.
• W4387446611 cites W3130188116 @default.
• W4387446611 cites W3189399866 @default.
• W4387446611 cites W3197166860 @default.
• W4387446611 cites W374904728 @default.
• W4387446611 cites W4206939795 @default.
• W4387446611 cites W4281624245 @default.
• W4387446611 cites W4283765206 @default.
• W4387446611 cites W4318924391 @default.
• W4387446611 cites W4368351259 @default.
• W4387446611 cites W4386097795 @default.
• W4387446611 doi "https://doi.org/10.21203/rs.3.rs-3402517/v1" @default.
• W4387446611 hasPublicationYear "2023" @default.
• W4387446611 type Work @default.
• W4387446611 citedByCount "0" @default.
• W4387446611 crossrefType "posted-content" @default.
• W4387446611 hasAuthorship W4387446611A5004608798 @default.
• W4387446611 hasAuthorship W4387446611A5026577550 @default.
• W4387446611 hasAuthorship W4387446611A5081215156 @default.
• W4387446611 hasAuthorship W4387446611A5087918689 @default.
• W4387446611 hasBestOaLocation W43874466111 @default.
• W4387446611 hasConcept C118552586 @default.
• W4387446611 hasConcept C126322002 @default.
• W4387446611 hasConcept C134018914 @default.
• W4387446611 hasConcept C136569192 @default.
• W4387446611 hasConcept C139719470 @default.
• W4387446611 hasConcept C148762608 @default.
• W4387446611 hasConcept C15744967 @default.
• W4387446611 hasConcept C162324750 @default.
• W4387446611 hasConcept C173586616 @default.
• W4387446611 hasConcept C2776151105 @default.
• W4387446611 hasConcept C2776867660 @default.
• W4387446611 hasConcept C2777397205 @default.
• W4387446611 hasConcept C2779085643 @default.
• W4387446611 hasConcept C2779177272 @default.
• W4387446611 hasConcept C2780352252 @default.
• W4387446611 hasConcept C2780829032 @default.
• W4387446611 hasConcept C2781161787 @default.
• W4387446611 hasConcept C44752575 @default.
• W4387446611 hasConcept C558461103 @default.
• W4387446611 hasConcept C71315377 @default.
• W4387446611 hasConcept C71924100 @default.
• W4387446611 hasConceptScore W4387446611C118552586 @default.
• W4387446611 hasConceptScore W4387446611C126322002 @default.
• W4387446611 hasConceptScore W4387446611C134018914 @default.
• W4387446611 hasConceptScore W4387446611C136569192 @default.
• W4387446611 hasConceptScore W4387446611C139719470 @default.
• W4387446611 hasConceptScore W4387446611C148762608 @default.
• W4387446611 hasConceptScore W4387446611C15744967 @default.
• W4387446611 hasConceptScore W4387446611C162324750 @default.
• W4387446611 hasConceptScore W4387446611C173586616 @default.
• W4387446611 hasConceptScore W4387446611C2776151105 @default.
• W4387446611 hasConceptScore W4387446611C2776867660 @default.
• W4387446611 hasConceptScore W4387446611C2777397205 @default.
• W4387446611 hasConceptScore W4387446611C2779085643 @default.
• W4387446611 hasConceptScore W4387446611C2779177272 @default.
• W4387446611 hasConceptScore W4387446611C2780352252 @default.
• W4387446611 hasConceptScore W4387446611C2780829032 @default.
• W4387446611 hasConceptScore W4387446611C2781161787 @default.
• W4387446611 hasConceptScore W4387446611C44752575 @default.
• W4387446611 hasConceptScore W4387446611C558461103 @default.

• next