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- W4387447178 abstract "Hyperkalemia is a serious condition among intra-abdominal transplant recipients, and the safety and efficacy of sodium-zirconium cyclosilicate (SZC) for its management during the early post-transplant period are not well-established.Adults who received at least one 10-g dose of SZC within 14 days after an intra-abdominal transplant between January 2020 and July 2022 were included in our study. The primary outcome was the change in potassium (K+) levels following the first SZC dose. Other analyses explored adjunctive potassium-lowering therapies, potential gastrointestinal complications, and patient subgroups based on therapy and transplant type.Among the recipients (n = 46), 11 were kidney recipients, 26 were liver recipients, seven were simultaneous liver/kidney recipients, and two were simultaneous pancreas/kidney recipients. The mean time to first dose post-transplant was 7.6 (±4) days, and the mean change in serum K+ after the initial SZC dose was -.27 mEq (p = .001). No gastrointestinal complications were observed following the SZC dose. The mean increase in serum bicarbonate was .58 mEq (p = .41) following the first dose of SZC. Four kidney recipients required dialysis following the SZC dose.This study represents the largest investigation on the use of SZC in transplant recipients. A single 10-g dose of SZC reduced serum K+ levels in all subgroups, while the use of adjunctive K+-lowering therapies did not provide additional reduction beyond the effects of SZC. Importantly, no gastrointestinal complications were observed. These findings suggest that SZC may be a safe and promising therapeutic option for hyperkalemia management following solid organ transplantation." @default.
- W4387447178 created "2023-10-10" @default.
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- W4387447178 date "2023-10-09" @default.
- W4387447178 modified "2023-10-11" @default.
- W4387447178 title "Potassium‐lowering effects of sodium‐zirconium cyclosilicate in the early post‐transplant period" @default.
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- W4387447178 doi "https://doi.org/10.1111/ctr.15156" @default.
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