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- W4387448907 abstract "This work describes a unique ultrasound exposure system designed to create very localized (~100μm) sound fields at operating frequencies that are currently being used for pre-clinical ultrasound neuromodulation. This system can expose small clusters of neuronal tissue, such as cell cultures or intact brain structures in target animal models, opening up opportunities to examine possible mechanisms of action. We modified a dental descaler, and drove it at a resonance frequency of 96kHz, well above its nominal operating point of 28kHz. A ceramic microtip from an ultrasonic wire bonder was attached to the end of the applicator, creating a 100μm point source. The device was calibrated with a polyvinylidene difluoride (PVDF) membrane hydrophone, in a novel, air-backed, configuration. Experimental results were confirmed by simulation using a monopole model. The results show a consistent exponentially decaying sound field from the tip, well suited to neural stimulation. The system was tested on an existing neurological model, Drosophila melanogaster, which has not previously been used for ultrasound neuromodulation experiments. The results show brain directed ultrasound stimulation induces or suppresses motor actions, demonstrated through synchronized tracking of fly limb movements. These results provide the basis for ongoing and future studies of ultrasound interaction with neuronal tissue, both at the level of single neurons and intact organisms." @default.
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- W4387448907 date "2023-01-01" @default.
- W4387448907 modified "2023-10-11" @default.
- W4387448907 title "A Miniature Ultrasound Source for Neural Modulation" @default.
- W4387448907 doi "https://doi.org/10.1109/tuffc.2023.3322963" @default.
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