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- W4387449315 endingPage "115850" @default.
- W4387449315 startingPage "115850" @default.
- W4387449315 abstract "The growing information currently available on the central role of non-coding RNAs (ncRNAs) including microRNAs (miRNAS) and long non-coding RNAs (lncRNAs) for chronic and degenerative human diseases makes them attractive therapeutic targets. RNAs carry out different functional roles in human biology and are deeply deregulated in several diseases. So far, different attempts to therapeutically target the 3D RNA structures with small molecules have been reported. In this scenario, the development of computational tools suitable for describing RNA structures and their potential interactions with small molecules is gaining more and more interest. Here, we describe the most suitable strategies to study ncRNAs through computational tools. We focus on methods capable of predicting 2D and 3D ncRNA structures. Furthermore, we describe computational tools to identify, design and optimize small molecule ncRNA binders. This review aims to outline the state of the art and perspectives of computational methods for ncRNAs over the past decade." @default.
- W4387449315 created "2023-10-10" @default.
- W4387449315 creator A5000930768 @default.
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- W4387449315 creator A5093027088 @default.
- W4387449315 creator A5093027089 @default.
- W4387449315 date "2023-10-01" @default.
- W4387449315 modified "2023-10-11" @default.
- W4387449315 title "Targeting non-coding RNAs: Perspectives and challenges of in-silico approaches" @default.
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