FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387449889> ?p ?o ?g. }

• W4387449889 endingPage "1623" @default.
• W4387449889 startingPage "1614" @default.
• W4387449889 abstract "Congenital heart disease (CHD) remains a significant risk factor for neurologic injury because altered fetal hemodynamics may be unable to support typical brain development during critical periods of growth and maturation. The primary objective was to assess differences in the cerebral biochemical profile between healthy fetuses and fetuses with complex CHD and to relate these with infant outcomes. Pregnant participants underwent fetal magnetic resonance imaging with cerebral proton magnetic resonance spectroscopy acquisitions as part of a prospective observational study. Cerebral metabolites of N-acetyl aspartate, creatine, choline, myo-inositol, scyllo-inositol, lactate, and relevant ratios were quantified using LCModel. We acquired 503 proton magnetic resonance spectroscopy images (controls = 333; CHD = 170) from 333 participants (controls = 221; CHD = 112). Mean choline levels were higher in CHD compared with controls (CHD 2.47 IU [Institutional Units] ± 0.44 and Controls 2.35 IU ± 0.45; P = 0.02), whereas N-acetyl aspartate:choline ratios were lower among CHD fetuses compared with controls (CHD 1.34 ± 0.40 IU vs controls 1.44 ± 0.48 IU; P = 0.001). Cerebral lactate was detected in all cohorts but increased in fetuses with transposition of the great arteries and single-ventricle CHD (median: 1.63 [IQR: 0.56-3.27] in transposition of the great arteries and median: 1.28 [IQR: 0-2.42] in single-ventricle CHD) compared with 2-ventricle CHD (median: 0.79 [IQR: 0-1.45]). Cerebral lactate also was associated with increased odds of death before discharge (OR: 1.75; P = 0.04). CHD is associated with altered cerebral metabolites in utero, particularly in the third trimester period of pregnancy, which is characterized by exponential brain growth and maturation, and is associated with survival to hospital discharge. The long-term neurodevelopmental consequences of these findings warrant further study." @default.
• W4387449889 created "2023-10-10" @default.
• W4387449889 creator A5019736586 @default.
• W4387449889 creator A5022456078 @default.
• W4387449889 creator A5034342115 @default.
• W4387449889 creator A5038773998 @default.
• W4387449889 creator A5039085427 @default.
• W4387449889 creator A5041532294 @default.
• W4387449889 creator A5044280378 @default.
• W4387449889 creator A5046647819 @default.
• W4387449889 creator A5062478612 @default.
• W4387449889 creator A5078730894 @default.
• W4387449889 date "2023-10-01" @default.
• W4387449889 modified "2023-10-18" @default.
• W4387449889 title "Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease" @default.
• W4387449889 cites W123385818 @default.
• W4387449889 cites W1557128794 @default.
• W4387449889 cites W1902838673 @default.
• W4387449889 cites W1904095712 @default.
• W4387449889 cites W1951724000 @default.
• W4387449889 cites W1963697249 @default.
• W4387449889 cites W1967033246 @default.
• W4387449889 cites W1968493125 @default.
• W4387449889 cites W1973142402 @default.
• W4387449889 cites W1975557508 @default.
• W4387449889 cites W1977425029 @default.
• W4387449889 cites W1996831127 @default.
• W4387449889 cites W2002008118 @default.
• W4387449889 cites W2002403913 @default.
• W4387449889 cites W2022951655 @default.
• W4387449889 cites W2027876153 @default.
• W4387449889 cites W2028378804 @default.
• W4387449889 cites W2032246984 @default.
• W4387449889 cites W2038518183 @default.
• W4387449889 cites W2038979894 @default.
• W4387449889 cites W2041678833 @default.
• W4387449889 cites W2042862484 @default.
• W4387449889 cites W2049027812 @default.
• W4387449889 cites W2064531734 @default.
• W4387449889 cites W2068174282 @default.
• W4387449889 cites W2089594690 @default.
• W4387449889 cites W2092565569 @default.
• W4387449889 cites W2104408320 @default.
• W4387449889 cites W2397467584 @default.
• W4387449889 cites W2523293547 @default.
• W4387449889 cites W2526584780 @default.
• W4387449889 cites W2769935266 @default.
• W4387449889 cites W2886201673 @default.
• W4387449889 cites W2889037293 @default.
• W4387449889 cites W2891175925 @default.
• W4387449889 cites W2892974343 @default.
• W4387449889 cites W2927056306 @default.
• W4387449889 cites W3012602033 @default.
• W4387449889 cites W3033467156 @default.
• W4387449889 cites W3094399814 @default.
• W4387449889 cites W3134477073 @default.
• W4387449889 cites W41104782 @default.
• W4387449889 cites W4211172457 @default.
• W4387449889 doi "https://doi.org/10.1016/j.jacc.2023.08.013" @default.
• W4387449889 hasPublicationYear "2023" @default.
• W4387449889 type Work @default.
• W4387449889 citedByCount "1" @default.
• W4387449889 crossrefType "journal-article" @default.
• W4387449889 hasAuthorship W4387449889A5019736586 @default.
• W4387449889 hasAuthorship W4387449889A5022456078 @default.
• W4387449889 hasAuthorship W4387449889A5034342115 @default.
• W4387449889 hasAuthorship W4387449889A5038773998 @default.
• W4387449889 hasAuthorship W4387449889A5039085427 @default.
• W4387449889 hasAuthorship W4387449889A5041532294 @default.
• W4387449889 hasAuthorship W4387449889A5044280378 @default.
• W4387449889 hasAuthorship W4387449889A5046647819 @default.
• W4387449889 hasAuthorship W4387449889A5062478612 @default.
• W4387449889 hasAuthorship W4387449889A5078730894 @default.
• W4387449889 hasConcept C126322002 @default.
• W4387449889 hasConcept C126838900 @default.
• W4387449889 hasConcept C134018914 @default.
• W4387449889 hasConcept C143409427 @default.
• W4387449889 hasConcept C164705383 @default.
• W4387449889 hasConcept C172680121 @default.
• W4387449889 hasConcept C2776064143 @default.
• W4387449889 hasConcept C2778921608 @default.
• W4387449889 hasConcept C2779234561 @default.
• W4387449889 hasConcept C2779896295 @default.
• W4387449889 hasConcept C2780074459 @default.
• W4387449889 hasConcept C2781123555 @default.
• W4387449889 hasConcept C54355233 @default.
• W4387449889 hasConcept C71924100 @default.
• W4387449889 hasConcept C86803240 @default.
• W4387449889 hasConceptScore W4387449889C126322002 @default.
• W4387449889 hasConceptScore W4387449889C126838900 @default.
• W4387449889 hasConceptScore W4387449889C134018914 @default.
• W4387449889 hasConceptScore W4387449889C143409427 @default.
• W4387449889 hasConceptScore W4387449889C164705383 @default.
• W4387449889 hasConceptScore W4387449889C172680121 @default.
• W4387449889 hasConceptScore W4387449889C2776064143 @default.
• W4387449889 hasConceptScore W4387449889C2778921608 @default.
• W4387449889 hasConceptScore W4387449889C2779234561 @default.
• W4387449889 hasConceptScore W4387449889C2779896295 @default.

• next