Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387451041> ?p ?o ?g. }
- W4387451041 endingPage "8137" @default.
- W4387451041 startingPage "8126" @default.
- W4387451041 abstract "This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin’s impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK family members tested, silibinin had a limited effect on JNK and p38 but significantly inhibited ERK1/2 and related RSK1/2. Silibinin also inhibited MKK6, AKT3, MSK2, p70S6K, and GSK-3β. These findings highlight silibinin’s potent inhibitory effects on phagocytosis and morphological changes in macrophages. We suggest its potential as an anti-inflammatory agent due to its ability to target key inflammatory pathways involving ERK1/2 and related kinases. Overall, this study demonstrates the promising therapeutic properties of silibinin in modulating macrophage function and inflammation." @default.
- W4387451041 created "2023-10-10" @default.
- W4387451041 creator A5041172106 @default.
- W4387451041 creator A5056803972 @default.
- W4387451041 creator A5069914511 @default.
- W4387451041 date "2023-10-06" @default.
- W4387451041 modified "2023-10-11" @default.
- W4387451041 title "Inhibition of Phagocytosis by Silibinin in Mouse Macrophages" @default.
- W4387451041 cites W1480188565 @default.
- W4387451041 cites W1487737439 @default.
- W4387451041 cites W1506569093 @default.
- W4387451041 cites W1980463804 @default.
- W4387451041 cites W1993470618 @default.
- W4387451041 cites W1993660328 @default.
- W4387451041 cites W1994942139 @default.
- W4387451041 cites W1997925678 @default.
- W4387451041 cites W2001076166 @default.
- W4387451041 cites W2017818235 @default.
- W4387451041 cites W2022666838 @default.
- W4387451041 cites W2023105368 @default.
- W4387451041 cites W2027215652 @default.
- W4387451041 cites W2032582358 @default.
- W4387451041 cites W2038099959 @default.
- W4387451041 cites W2038634187 @default.
- W4387451041 cites W2055311718 @default.
- W4387451041 cites W2060066878 @default.
- W4387451041 cites W2069125860 @default.
- W4387451041 cites W2074011532 @default.
- W4387451041 cites W2075595064 @default.
- W4387451041 cites W2075901113 @default.
- W4387451041 cites W2097707819 @default.
- W4387451041 cites W2101568779 @default.
- W4387451041 cites W2104425579 @default.
- W4387451041 cites W2104633821 @default.
- W4387451041 cites W2113798710 @default.
- W4387451041 cites W2118278569 @default.
- W4387451041 cites W2135148254 @default.
- W4387451041 cites W2135469933 @default.
- W4387451041 cites W2140380746 @default.
- W4387451041 cites W2144452002 @default.
- W4387451041 cites W2168586729 @default.
- W4387451041 cites W2170948660 @default.
- W4387451041 cites W2489667194 @default.
- W4387451041 cites W2568926318 @default.
- W4387451041 cites W2585846097 @default.
- W4387451041 cites W2601031157 @default.
- W4387451041 cites W2604841788 @default.
- W4387451041 cites W2786954262 @default.
- W4387451041 cites W2911722708 @default.
- W4387451041 doi "https://doi.org/10.3390/cimb45100513" @default.
- W4387451041 hasPublicationYear "2023" @default.
- W4387451041 type Work @default.
- W4387451041 citedByCount "0" @default.
- W4387451041 crossrefType "journal-article" @default.
- W4387451041 hasAuthorship W4387451041A5041172106 @default.
- W4387451041 hasAuthorship W4387451041A5056803972 @default.
- W4387451041 hasAuthorship W4387451041A5069914511 @default.
- W4387451041 hasBestOaLocation W43874510411 @default.
- W4387451041 hasConcept C160448771 @default.
- W4387451041 hasConcept C184235292 @default.
- W4387451041 hasConcept C185592680 @default.
- W4387451041 hasConcept C202751555 @default.
- W4387451041 hasConcept C203014093 @default.
- W4387451041 hasConcept C2776914184 @default.
- W4387451041 hasConcept C2777130413 @default.
- W4387451041 hasConcept C2778754761 @default.
- W4387451041 hasConcept C2779244956 @default.
- W4387451041 hasConcept C2780210117 @default.
- W4387451041 hasConcept C51551487 @default.
- W4387451041 hasConcept C55493867 @default.
- W4387451041 hasConcept C57074206 @default.
- W4387451041 hasConcept C59822182 @default.
- W4387451041 hasConcept C86803240 @default.
- W4387451041 hasConcept C95444343 @default.
- W4387451041 hasConcept C98274493 @default.
- W4387451041 hasConceptScore W4387451041C160448771 @default.
- W4387451041 hasConceptScore W4387451041C184235292 @default.
- W4387451041 hasConceptScore W4387451041C185592680 @default.
- W4387451041 hasConceptScore W4387451041C202751555 @default.
- W4387451041 hasConceptScore W4387451041C203014093 @default.
- W4387451041 hasConceptScore W4387451041C2776914184 @default.
- W4387451041 hasConceptScore W4387451041C2777130413 @default.
- W4387451041 hasConceptScore W4387451041C2778754761 @default.
- W4387451041 hasConceptScore W4387451041C2779244956 @default.
- W4387451041 hasConceptScore W4387451041C2780210117 @default.
- W4387451041 hasConceptScore W4387451041C51551487 @default.
- W4387451041 hasConceptScore W4387451041C55493867 @default.
- W4387451041 hasConceptScore W4387451041C57074206 @default.
- W4387451041 hasConceptScore W4387451041C59822182 @default.
- W4387451041 hasConceptScore W4387451041C86803240 @default.
- W4387451041 hasConceptScore W4387451041C95444343 @default.
- W4387451041 hasConceptScore W4387451041C98274493 @default.
- W4387451041 hasIssue "10" @default.
- W4387451041 hasLocation W43874510411 @default.
- W4387451041 hasOpenAccess W4387451041 @default.
- W4387451041 hasPrimaryLocation W43874510411 @default.
- W4387451041 hasRelatedWork W156474234 @default.
- W4387451041 hasRelatedWork W1602872167 @default.